https://padlet.com/sealsdf/8vmljt0rs2s14xrw Response to 3 of the following 5 questions on this Padlet. Match your answer to the appropriate question number. 1. Is a mutation in the hemoglobin gene likely to cause cancer? 2. Why are malignant tumor life-threatening? 3. Regardless of its impact on how these cancers are treated, why do you think that triple negative breast cancers might be so naturally aggressive? 4. How might individual mutations in a single gene alter gene expression patterns throughout a cancerous cell? 5. What limitations might there be on a patient's therapeutic options to a Stage 4 cancer versus a Stage 1 cancer? en-us 2021-01-21 18:29:11 UTC 2026-03-14 09:17:28 UTC hello@padlet.com sealsdf https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1111480785 1. Is a mutation in the hemoglobin gene likely to cause cancer?
2. Why are malignant tumor life-threatening?
3. Regardless of its impact on how these cancers are treated, why do you think that triple negative breast cancers might be so naturally aggressive?
4. How might individual mutations in a single gene alter gene expression patterns throughout a cancerous cell?5. What limitations might there be on a patient's therapeutic options to a Stage 4 cancer versus a Stage 1 cancer?]]> 2021-01-21 18:40:21 UTC https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1111480785 https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112063690 1.  No,  there would have to be several mutations that occur to cause cancer. Also, the gene expression causes cancer in some cases (such as silent mutations)
2.  Malignant tumors are life threatening because they invade tissues quickly and grow rapidly
3. Triple negative breast cancers do not have receptors that cancer drugs can target, making these types of cancers naturally aggressive. ]]> 2021-01-21 20:52:36 UTC https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112063690 https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112067045 1. No--- This type of mutation can cause other pathologies such as sickle cell anemia, but is not related to the cell's growth. Therefore, it is not likely to contribute to cancer.
2. Malignant tumors can spread easily, and are more difficult to target during treatment. 
5. Stage 4 cancer would be harder to treat because the cancer has spread over a large area of the body. This would exclude therapies that are targeted, such as targeted radiation and surgery, which might be possible during Stage 1.]]> 2021-01-21 20:53:34 UTC https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112067045 https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112067934 1. No, multiple mutations are necessary in order to cause cancer.
2. As tumors grow and spread throughout the body, they become harder to treat. 
3. Triple negative breast cancers are so aggressive because they do not have the cellular receptors that can be targeted with drugs.

]]> 2021-01-21 20:53:50 UTC https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112067934 sealsdf https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112218385 Some genes encode for transcription factors that when mutated alter their ability to bind to the promoters of other genes in order to up- or down-regulate their expression. Likewise, mutations in some genes alter the activation state of a downstream transcription factor within a signaling pathway. Many transcription factors have a role in cancer, and that is at least one reason why gene expression patterns in cancer cells can be so different from the normal cells from which they were derived.]]> 2021-01-21 21:44:15 UTC https://padlet.com/sealsdf/8vmljt0rs2s14xrw/wish/1112218385