The beginning of the Neolithic culture is considered to be in the Levant (Jericho, modern-day West Bank) about 10,200–8800 BC. It developed directly from the Epipaleolithic Natufian culture in the region, whose people pioneered the use of wild cereals, which then evolved into true farming. The Natufian period lasted between 12,500 and 9,500 BC, and the so-called "proto-Neolithic" is now included in the Pre-Pottery Neolithic (PPNA) between 10,200 and 8800 BC. As the Natufians had become dependent on wild cereals in their diet, and a sedentary way of life had begun among them, the climatic changes associated with the Younger Dryas are thought to have forced people to develop farming.

By 10,200–8800 BC, farming communities arose in the Levant and spread to Asia Minor, North Africa and North Mesopotamia. Mesopotamia is the site of the earliest developments of the Neolithic Revolution from around 10,000 BC.

Early Neolithic farming was limited to a narrow range of plants, both wild and domesticated, which included einkorn wheat, millet and spelt, and the keeping of dogs, sheep and goats. By about 6900–6400 BC, it included domesticated cattle and pigs, the establishment of permanently or seasonally inhabited settlements, and the use of pottery.