Explain the advantages and disadvantages of transgenic animals by Megan Zavala https://padlet.com/st12103891/8l6kim3pokpl55il By: Megan and Yossi en-us 2022-05-09 18:30:57 UTC 2022-05-12 03:35:36 UTC hello@padlet.com https://padlet.net/icons/png/1f9ec.png What are transgenic animals? st12103911 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179787002 A transgenic animal is when an animal's genome has been altered by transferring one or more genes from another breed or species.

They are a very important model within biomedical research used for researching human disease and understanding gene function in terms of a disease to determine a solution.]]> 2022-05-11 16:56:25 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179787002 st12103911 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179787947 Two transgenic mice shown with a regular mouse in the middle. The transgenic mice have been genetically altered to carry a green fluorescent protein that glows green when exposed to blue light.
Credit: Ingrid Moen et alet al., BMC Cancer, 12/21 (2012), 1-10.]]> 2022-05-11 16:56:58 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179787947 Advantages st12103911 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179792910 - transgenic animals have been used to produce human antibodies
Example: antithrombin lll, a protein found in transgenic goats milk is used for people who have hereditary antithrombin deficiency and are going to have surgery or childbirth

- provide a model that closely mimics the human body = greater insight and test experimental drugs
- function of a specific gene at the level of the whole organism

of transgenic mice:
- extensive analysis of their genome sequence 
-  genome is similar to humans
- psychological and behavioral tests can be related to humans
- techniques are available for the manipulation of mice
- short reproduction cycle ]]> 2022-05-11 17:00:06 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179792910 Disadvantages st12103911 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179809351 - extremely expensive
- could be a high mortality rate
Example: transgenic pigs have higher rates of developing arthritis, dermatitis, and reduced reproductive performance

- high level of genetic mutations
- reliability is questionable
Example: 0.6% of pigs were born with the desired genes after 7,000 eggs were injected

- ethical considerations  
- there are some apprehensions about the safety of transgenic foods]]> 2022-05-11 17:10:52 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179809351 Discovery st12103891 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179842457 - Needs the ability to transfer and manipulate embryos
- Walter Heape in Angora Rabbits 1891
- 1st genetic modification on animals 1974 by Rudolph Jaenisch]]> 2022-05-11 17:32:00 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2179842457 Sources st12103891 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180230096 Chief, Editor in. “20 Biggest Pros and Cons of Transgenic Animals.” ConnectUS, 8 May 2019, https://connectusfund.org/9-biggest-pros-and-cons-of-transgenic-animals. 

“Transgenic Animals: Advantages and Disadvantages.” BioTechnology Notes, 16 May 2016, https://www.biotechnologynotes.com/animals/transgenic-animals/transgenic-animals-advantages-and-disadvantages/678#:~:text=Disadvantages%20of%20Transgenic%20Animals%3A&text=(b)%20Generation%20of%20transgenic%20animals,researchers%20to%20create%20transgenic%20breeds. 

“Transgenic Animals Have Genes from Other Species Inserted into Their Genomes.” WhatisBiotechnology.org, https://whatisbiotechnology.org/index.php/science/summary/transgenic/transgenic-animals-have-genes-from-other-species-inserted. 
]]> 2022-05-11 23:39:30 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180230096 Process st12103891 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180231728 2022-05-11 23:41:29 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180231728 st12103891 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180233607 Small improvements in milk volume in Guzerat cows (left) using genetic material from high-producing Holsteins (right) could have a significant impact on Brazilian beef production (Wheeler et al. 2010.]]> 2022-05-11 23:43:39 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180233607 st12103891 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180244437 Late 90s, Charles and Joseph Vacanti and Bob Langer genetically modify a mouse to grow a human ear on its body which was used to help understand how humans could grow body parts using their skin and cartilage. ]]> 2022-05-11 23:55:57 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180244437 st12103891 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180299581 2022-05-12 00:43:30 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180299581 st12103891 https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180523920 2022-05-12 03:35:27 UTC https://padlet.com/st12103891/8l6kim3pokpl55il/wish/2180523920