-Abrupt discontinuation can result in withdrawal symptoms (nausea, sweating, agitation, tremor, insomnia, seizures)

Adverse Effects:
Agitation, insomnia, HA, dizziness, somnolence, fatigue.

Contraindications:
Concomitant use of this drug with MAOI or pimozide is not advised. Antabuse should be avoided due to alcohol content of drug concentrate. CAUTION w/cardiac disease, hepatic imparement, seizure disorders, SI, mania, hypomania.

BLACK BOX WARNING:
Antidepressents increase the risk of SI and behavior (especially in children, adolescents and young adults with major depressive disorder/other psychiatric disorders). Do not use in pediatric patients with major depressive disorder but can be used for OCD in children under 6.

Pharmacokinetics:
Onset: 2-4 weeks
Peak: Unknown
Duratoin: Variable (due to extensive binding with serum proteins)

Interactions:
Drug: Highly protein bound meds (digoxin, warfarin, etc) = risk of toxicity/increased blood concentrations > increased bleeding. MAOIs may cause neurleptic mallgnant syndrome, extreme hypertension and SES (confusion, anxiety, restlessness, HTN, tremors, sweating, hyperpyrexia, or ataxia). Caution w/other centrally acting drugs to avoid CNS effects.
Labs: ^liver functoni tests (asymptomatic), slight decrease in uric acid levels.
Herbs/food: St. Johns wort, L-tryptophan

Overdose:
None. Emergancy medical attention and supporive measures. 
Sx of OD: N/V, tremor, seizure, agitation, dizziness, hyperactivity, mydriasis, tachycardia, coma

Actions and Uses: Inhibits prostaglandin synthesis involved in pain and inflammation processes and produces mild to moderate relief of fever. Significant anticoagulant activity and this property are responsible for reducing the risk of mortality following M I and reducing the incidence of strokes.

Administration Alerts:

Platelet aggregation inhibition caused by aspirin is irreversible. Aspirin should be discontinued 1 week prior to surgery. Aspirin is excreted in the urine and affects urine testing for glucose and other metabolites, such as vanillylmandelic acid (V M A).

Pregnancy category D.

Adverse Effects: At high doses, such as those used to treat severe inflammatory disorders, aspirin may cause gastric discomfort and bleeding because of its antiplatelet effects. 

Enteric-coated tablets and buffered preparations are available for patients who experience GI side effects.

Contraindications: Because aspirin increases bleeding time, it should not be given to patients receiving anticoagulant therapy such as warfarin and heparin.

Drug-Drug: Phenobarbital, antacids, and glucocorticoids may decrease aspirin’s effects. Aspirin may potentiate the action of oral hypoglycemic drugs. Taken with alcohol, pyrazolone derivatives, steroids, or other N S A I D s, there is an increased risk for gastric ulcers.

Lab Tests: Prolonged prothrombin time by decreasing prothrombin production. Aspirin may also interfere with pregnancy tests and decrease serum levels of cholesterol, potassium, P B I, T3, and T4. High salicylate levels may cause abnormalities in liver function tests.

Herbal/Food: Feverfew, garlic, ginger, and ginkgo may increase the risk of bleeding.

Treatment of Overdose: Treatment may include any of the following: activated charcoal, gastric lavage, laxative, or drug therapy for overdose symptoms such as dizziness, drowsiness, abdominal pain, or seizures.

Pregnancy category: B

Adverse Effects: daytime sedation, confusion, amnesia, dizziness, depression with suicidal thoughts, nausea, and vomiting.

Has been associated with the development of adverse neuropsychiatric reactions Hallucination, sensory distortion, sleepwalking, and nocturnal eating.
Food/Herbal: when taken with food, absorption is slowed significantly, and the onset of action may be delayed.
Treatment of overdose:
IV fluids should be administered as needed. Use of flumazenil (Romazicon) as a benzodiazepine receptor antagonist may be helpful.