SIMVASTATIN&STREPTOKINASE by Harriet Lisam https://padlet.com/lisamharriet/8elbhsjkci10iouq DRUGSTUDY (LISAM,HARRIET L.) en-us 2021-09-13 14:03:09 UTC 2021-09-13 15:21:20 UTC hello@padlet.com lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736230476
  • Zocor
  • Flolipid
    • ]]>     2021-09-13 14:14:47 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736230476     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736232011 Simvastatin]]> 2021-09-13 14:15:13 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736232011 lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736238696 Tablets:
    • 5 mg
    • 10 mg
    • 20 mg
    • 40 mg
    • 80 mg


    Prevention of coronary events:
    • 10–20 mg PO once daily in the evening. 

    • Presence of CHD or at high risk for cardiovascular events, including patients with diabetes, PVD, history of stroke or other cerebrovascular disease: 40 mg PO qDay in the evening adjunct to diet therapy (initiate simultaneously); adjust dose to achieve goal
    ]]>     2021-09-13 14:17:08 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736238696     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736252175 Therapeutic: lipid-lowering agents

    Pharmacologic: HMG-CoA reductase inhibitors (statin)

    ]]>     2021-09-13 14:20:53 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736252175     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736259255 It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.]]> 2021-09-13 14:22:49 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736259255 lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736277239
  • To reduce the risk of coronary disease, mortality, and CV events, including stroke, TIA, MI, and reduction in need for bypass surgery and angioplasty in patients with coronary heart disease and hypercholesterolemia.

    • ]]>     2021-09-13 14:27:26 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736277239     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736297806
  • Headache
  • Nausea
  • Stomach pain
  • Constipation
  • Muscle pain or weakness
  • Joint pain
  • Upper respiratory infections

    • ]]>     2021-09-13 14:33:04 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736297806     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736303487
  • CNS: Headache, asthenia, sleep disturbances  

    • GI: Flatulence, diarrhea, abdominal pain, cramps, constipation, nausea, dyspepsia, heartburn, liver failure  

    • Respiratory: Sinusitis, pharyngitis 

    • Other: Rhabdomyolysis, acute renal failure, arthralgia, myalgia
    ]]>     2021-09-13 14:34:35 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736303487     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736317067
  • Contraindicated with allergy to simvastatin, fungal by-products; active liver disease or unexplained, persistent elevations of serum transaminases; concurrent use of HIV protease inhibitors, erythromycin, clarithromycin, telithromycin, nefazodone, qemfifibrozil, cyclosporine, danazol; pregnancy, lactation.

    • Use cautiously with impaired hepatic and 
      renal function, cataracts, Asian-Americans 
      (increased risk of myopathy).
    ]]>     2021-09-13 14:37:56 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736317067     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736335391
  • Assess any joint pain, muscle pain, tenderness, or weakness, especially if accompanied by fever, malaise, and dark-colored urine. Advise patient that these symptoms may represent drug-induced myopathy and that myopathy can progress to severe muscle damage (rhabdomyolysis). Report any unexplained musculoskeletal symptoms to the physician immediately, and stop exercise and gait training until these symptoms can be assessed.

    • Monitor signs of hypersensitivity reactions, including pulmonary symptoms (tightness in the throat and chest, wheezing, cough, dyspnea) or skin reactions (rash, pruritus, urticaria). Notify physician if these reactions occur.

    • Assess dizziness that might affect gait, balance, and other functional activities. Report balance problems and functional limitations to the physician, and caution the patient and family/caregivers to guard against falls and trauma.

    • Design and implement aerobic exercise and endurance training programs to improve cardiovascular function and help reduce the risk of coronary heart disease.

    • Counsel patients about additional interventions to help control lipid disorders and improve cardiovascular health, including dietary modification, regular exercise, moderation of alcohol consumption, and smoking cessation.

    • Instruct patient to report signs of drug-induced hepatitis (anorexia, abdominal pain, severe nausea and vomiting, yellow skin or eyes, skin rashes, flu-like symptoms) or pancreatitis (upper abdominal pain after eating, indigestion, weight

    • Medication should be stored in a closed container in a cool, dry, dark place, out of the reach of children.
    ]]>     2021-09-13 14:42:44 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736335391     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736394877 Streptokinase]]> 2021-09-13 14:58:29 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736394877 lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736398169
  • Streptase
  • Kabbikinase


    • ]]>     2021-09-13 14:59:25 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736398169     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736406203 Injection: 
    • 250,000 IU in vials for reconstitution 
    • 750,000 IU in vials for reconstitution 
    • 1,500,000 IU in vials for reconstitution 
    ]]>     2021-09-13 15:01:24 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736406203     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736407658 Therapeutic: Thrombolytics

    Pharmacologic: Plasminogen activators

    ]]>     2021-09-13 15:01:48 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736407658     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736415297 Combines with plasminogen to form activator complexes, then converts plasminogen to plasmin, which is then able to degrade clot-bound fibrin.]]> 2021-09-13 15:03:57 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736415297 lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736416982
  • Acute myocardial infarction (MI). 
  • Pulmonary embolism (PE). 
  • Deep vein thrombosis (DVT). 
  • Acute peripheral arterial thrombosis. 
  • Occluded arteriovenous cannulae.
    • ]]>     2021-09-13 15:04:27 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736416982     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736431316
  • The thrombolytic nature of streptokinase makes it contraindicated in patients with active internal bleeding, as it can worsen bleeding in some patients.

    • It is also contraindicated in patients with severe uncontrolled hypertension, intracranial neoplasms, surgery within two months, recent stroke, and intraspinal surgery.

    • Administered with extreme caution to those who have experienced recent trauma, coagulopathies or hematologic diseases, gastrointestinal bleeding, infective endocarditis, obstetric deliveries, diabetic hemorrhagic retinopathy, organ biopsies, or previous puncture of a non-compressible vessel.
    ]]>     2021-09-13 15:08:17 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736431316     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736436351
  • Nausea
  • Headache
  • Dizziness
  • Low blood pressure
  • Mild fever
  • Bleeding from wounds or gums
  • Rash
  • Itching
  • Flushing
  • Muscle or bone pain
  • Shivering
  • Allergic reactions

    • ]]>     2021-09-13 15:09:30 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736436351     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736441678 CNS: Intracranial Hemorrhage.

    EENT: Epistaxis, Gingival Bleeding.

    Resp: Bronchospasm, Hemoptysis.

    CV: Reperfusion Arrhythmias, Hypotension, Recurrent Ischemia/Thromboembolism.

    GI: GI Bleeding, Hepatotoxicity, Nausea, Retroperitoneal Bleeding.

    GU: GU Tract Bleeding.

    Derm: Ecchymoses, Urticaria.

    Hemat: Bleeding.

    Local: Hemorrhage at injection site, Phlebitis at injection site.

    MS: Musculoskeletal Pain.

    Misc: Allergic Reactions, Including Anaphylaxis, Fever.]]>     2021-09-13 15:10:59 UTC https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736441678     lisamharriet https://padlet.com/lisamharriet/8elbhsjkci10iouq/wish/1736467487
  • Assess for signs of bleeding and hemorrhage, including bleeding gums, nosebleeds, unusual bruising, coughing up blood, black/tarry stools, hematuria, and a fall in hematocrit or blood pressure. Be especially alert for signs of intracranial bleeds, including sudden severe headache, confusion, nausea, vomiting, paralysis, numbness, speech problems, visual disturbances. Notify physician or nursing staff immediately if these signs occur.

    • Be alert for signs of recurrent cardiac ischemia (chest pain, pain radiating into the arm or jaw, shortness of breath, dizziness, sweating, anxiety) or recurrent peripheral arterial thrombosis (pain, cramping, coldness, cyanosis in the affected limb). Notify physician or nursing staff immediately if these signs occur.

    • Monitor signs of recurrent thromboembolism and PE such as shortness of breath, chest pain, cough, and bloody sputum. Notify physician immediately, and request objective tests (Doppler ultrasound, lung scan, others) if PE is suspected.

    • Assess heart rate, ECG, and heart sounds when cardiac perfusion is restored. Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness.

    • Assess any muscle of joint pain to rule out musculoskeletal pathology or hemorrhage; that is, try to determine if pain is drug induced rather than caused by anatomic or biomechanical problems. Be especially concerned about back pain that could indicate retroperitoneal bleeding.



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