https://padlet.com/sjackson921/8bpn45tesqfpq7m5 Made with a wink and a smile en-us 2022-05-23 18:44:25 UTC 2022-06-23 14:35:20 UTC hello@padlet.com soyoungchoi https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217792079 Thyroid hormone synthesis inhibitor that is used for treatment of hyperthyroidism. It blocks the oxidation of iodine in the thyroid gland, and also blocks synthesis of T3, yet does not inactivate circulating T4 and T3 already in blood. 
Image from: https://doctorlib.info/pharmacology/pharmacology-examination-board-review/38.html

SYC]]> 2022-06-10 19:41:51 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217792079 soyoungchoi https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217818469 It is a tablet, given oral route, onset of action happens 12 to 18 hours. The distribution is concentrated in thyroid gland, metabolized by liver, and excreted by kidney. Initial dose is individualized by T4 levels.
Free T4 levels 1 to 1.5 times ULN: 5 to 10 mg once daily
1.5 to 2 times: 10 to 20 mg once daily
more than 2 times: 20 to 40 mg once daily.
Maintenance dose: 5 to 10 mg once daily with 4-6 week total T3 and free T4 assessment. 
Image from: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a57ff449-e3b7-48b6-9acf-c719a9770e8a&type=display

SYC]]> 2022-06-10 20:41:28 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217818469 soyoungchoi https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217821102 Methimazole Tablets, USP. (n.d.). Lexicomp. Retrieved June 10, 2022, from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a57ff449-e3b7-48b6-9acf-c719a9770e8a&type=display

Methimazole. Dynamed. Retrieved June 10, 2022, from https://www.dynamed.com/drug-monograph/methimazole#GUID-DA8A5482-0B82-4D4D-8B71-0FBFFF827227

Holman, H. C., Williams, D., Sommer, S., Johnson, J., Ball, B. S., Morris, C., Wheless, L. K., McMichael, M., Roland, P., Leehy, P., & Hertel, R. (2019). RN Pharmacology for Nursing: Review Module 8th Edition. Assessment Technologies Institute. 

]]> 2022-06-10 20:47:37 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217821102 soyoungchoi https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217827540 Hyperthyroidism associated with
- Graves disease
- Toxic multinodular goiter
- Toxic adenoma
- Iodine-induced thyrotoxicosis
Thyroid Storm
Thyrotoxicosis, type I amodarone-induced
Image from: https://www.ezmedlearning.com/blog/hyperthyroidism-vs-hypothyroidism-symptoms

SYC]]> 2022-06-10 21:01:00 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2217827540 https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221153858 Should not be used with: 
Bupropion
Tegafur

Concurrent use with anticoagulants increases anticoagulation
Concurrent use with digoxin can increase glycoside levels

SJ


]]> 2022-06-14 19:57:36 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221153858 https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221154244 Common: 
- Rash
- Arthritis

Serious: 
- Hypothyroidism (drowsiness, depression, weight gain, edema, dry skin, etc.)
- Agranulocytosis (sore throat, fever) 
- Vasculitis
- Pancreatitis
- Aplastic Anemia
- Hepatotoxicity

SJ]]> 2022-06-14 19:58:00 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221154244 https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221154381 Pre-administration: 
Contraindicated in pregnancy (Category D)
Educate that therapeutic effect can take 1-2 weeks

Administration: 
Wear gloves when handling, double gloves if cutting, crushing, or manipulating uncoated tablets

Post administration/Monitoring:
Thyroid function tests should be conducted 2-6 weeks after initiation, 4-6 weeks after dose change, then every 2-3 months once stabilized. 
Monitor TSH and T4 levels
Hypothyroidism can occur, routinely monitor and adjust dosage accordingly
Advise patient to report any symptoms of serious adverse reactions
- new rash, hematuria, drug fever, dyspnea, etc. 
Medication should be taken at consistent times each day and with meals

SJ]]> 2022-06-14 19:58:16 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221154381 https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221154557 A patient taking Methimazole is preparing for discharge and the nurse is providing discharge education. Which of the following indicates the patient understood the teaching? 
A. It's fine if I take this medication at different times each day
B. This medication will help with my hypothyroidism
C. I need to get my thyroid checked every 2-3 months after taking this medication for a while
D. If I get pregnant while on this medication, I can keep taking it. 

SJ]]> 2022-06-14 19:58:37 UTC https://padlet.com/sjackson921/8bpn45tesqfpq7m5/wish/2221154557