Genetic Disorder Research Project (ALS) by Michael Barron https://padlet.com/1071694/7qfpghcrhegc20bd Made with a quick smile en-us 2022-05-03 18:01:40 UTC 2022-05-06 15:50:49 UTC hello@padlet.com What is it? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2168755827 It is a type of disorder that affect the nerve cells that control voluntary muscle movements such as walking and talking. This causes the motor neuron to deteriorate and later on die.]]> 2022-05-03 18:07:43 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2168755827 Beginning Effect 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170168042 The type of effect that happens to you when you get ALS is you start to lose control of moving your body this is because the motor neuron is deteriorating and dying.]]> 2022-05-04 15:54:59 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170168042 End Effect 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170173336  You lose almost all control of your body and start dying because your lung muscles don't work so you are not getting oxygen, this leads to death which is the final stage of ALS.]]> 2022-05-04 15:58:24 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170173336 How many people in the US have ALS? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170174656 It affect as many as 30000 people, this could have been bigger but the people who had ALS just dies. For every year 5000 more people get ALS.]]> 2022-05-04 15:59:17 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170174656 How many people die to ALS? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170178270 It say to kill 5 people for every 100000 death at the age of 20 or older. ALS is the most common at people who are 60 and above.]]> 2022-05-04 16:01:41 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170178270 How does ALS get inherited? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170187148 ALS gets inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations.]]> 2022-05-04 16:07:05 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170187148 Type of test 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170191216
  • Electromyogram (EMG).
  • Nerve conduction study.
  • MRI.

    • ]]>     2022-05-04 16:09:42 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170191216     Can they be directly test and can you use amniotic fluid? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170197842 No they can not check directly usually they review the tests before giving a diagnosis and they can't use amniotic fluid because ALS does nothing to amniotic fluid.]]> 2022-05-04 16:14:07 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170197842 Therapies 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170203813 There are two type of therapies and both are drug. Riluzole which is a drug that can increase life expectancy to 3 to 6 months. Edaravone another type of drug allow the person with ALS to reduce the decline in daily functioning.]]> 2022-05-04 16:17:53 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170203813 How is ALS known? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170208439 ALS was discovered in 1869 by French neurologist Jean-Martin Charcot. It started to get more attention internationally in 1939 after killing a famous baseball player his name was Lou Gehrig.]]> 2022-05-04 16:20:49 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170208439 What is a support organization for ALS? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170214984 ALS Association is a support organization that makes no profit and helps people who have ALS. A nearby chapter is the Orange County Chapter which supports people with ALS.]]> 2022-05-04 16:24:52 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2170214984 People 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171724764 A celebrity that is promoting ALS is a baseball player. This helps show that ALS is a problem and this allows more people to know about it. Sadly this baseball player had ALS and sadly died later on but it shows what the people needed to do with ALS. The baseball player's name was San Francisco 49ers player Dwight Clark.

    ]]>     2022-05-05 16:30:55 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171724764     Day 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171725122 The Walk to Defeat ALS is a day where people raise money for ALS. The day that it happens is different for each state so I only say our Walk to Defeat ALS day which is May 14, 2022.]]> 2022-05-05 16:31:07 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171725122 Genes 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171738459 The gene that causes ALS is when C9orf72 starts mutations, this affects 30% to 40% of ALS people. Another gene is SOD1. This affects 15% to 20% of ALS people. The last genes only affect 5% of ALS people which are TARDBP and FUS.]]> 2022-05-05 16:40:09 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171738459 Oldest person with ALS? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171759496 Stephen Hawking, he had ALS for 55 years which is the longest time to live with ALS. He died at the age of 76 in 2018.]]> 2022-05-05 16:54:03 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171759496 Survivable 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171768872 It is 100% fatal so there are no chances of survival and there is no cure for ALS.]]> 2022-05-05 17:00:13 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171768872 How long to live with ALS? 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171773279 By average the life expectancy is 2 to 5 years. So to compare to the longest living person he live with ALS for 55 years.]]> 2022-05-05 17:03:14 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171773279 Diagnosis 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171776179 Diagnosis is very hard to do because in order to diagnose someone you have to rule out all the other diseases first before you can say they have ALS.]]> 2022-05-05 17:05:12 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171776179 Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171836116 Mayo Clinic
    Link:Amyotrophic lateral sclerosis (ALS) - Symptoms and causes - Mayo Clinic



    ]]>     2022-05-05 17:42:59 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171836116     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171839264 MedlinePlus
    Link:Look at the Causes, place them at the bottom of the page




    ]]>     2022-05-05 17:45:01 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171839264     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171841197 Mayo Clinic
    Link:Amyotrophic lateral sclerosis (ALS) - Symptoms and causes



    ]]>     2022-05-05 17:46:17 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171841197     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171842343 Johns Hopkins Medicine
    Link: ALS, Amyotrophic Lateral Sclerosis, Lou Gehrig's disease]]>     2022-05-05 17:47:03 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171842343     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171843506 MedlinePlus
    Link:Amyotrophic lateral sclerosis: MedlinePlus Genetics

    ]]>     2022-05-05 17:47:52 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171843506     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171844865 Mayo Clinic and the ALS Association
    Link:Amyotrophic lateral sclerosis (ALS) - Diagnosis and treatment - Mayo Clinic

    Genetics Testing - The ALS Association

    Genetic Testing for ALS | The ALS Association

    Obtaining an ALS Diagnosis | The ALS Association
    ]]>     2022-05-05 17:48:47 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171844865     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171847594 Mayo Clinic and BioPharma Dive
    Link:Amyotrophic lateral sclerosis (ALS) - Diagnosis and treatment - Mayo Clinic 

    On the hunt for new ALS drugs, researchers see progress, and a long road ahead | BioPharma Dive. 
    ]]>     2022-05-05 17:50:32 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171847594     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171848665 The ALS Association and National Institute of Neurological Disorders and Stroke
    Link:Helping You Understand ALS | The ALS Association. Amyotrophic Lateral Sclerosis (ALS) Fact Sheet | National Institute of Neurological Disorders and Stroke




    ]]>     2022-05-05 17:51:16 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171848665     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171851114 CDC and ALS Association
    Link: Organizations that Support ALS Patients and Caregivers

    http://weboc.alsa.org/site/PageServer?pagename=OC_homepage&_ga=2.59620901.969902862.1651506620-1924520794.1651506620
    ]]>     2022-05-05 17:52:57 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171851114     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171852118 Alstreatment
    Link:Famous People Who Have or Have Had ALS - Alstreatment.com

    Chapter Highlights
    ]]>     2022-05-05 17:53:40 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171852118     Sources 1071694 https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171855513 Wikipedia and VA Health Care
    Link:https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwjRg7v79sj3AhUYC0QIHSqOCgcQFnoECAkQAw&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FList_of_people_with_motor_neuron_disease&usg=AOvVaw2bO8ZdmbMKW4jY_WTjxNT3

    sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwiQxqu198j3AhWFIUQIHelXANoQFnoECAYQAQ&url=https%3A%2F%2Fwww.research.va.gov%2Fprograms%2Ftissue_banking%2Fals_caregivers%2FALSFactSheet_NAR.pdf&usg=AOvVaw1ZfxeB39WCj3RQgk4wuoZF]]>     2022-05-05 17:55:56 UTC https://padlet.com/1071694/7qfpghcrhegc20bd/wish/2171855513