https://padlet.com/paige_snyder1/7k3i0ep3oi2q By: Paige Snyder, Lauren Brown en-us 2019-05-09 16:08:01 UTC 2019-05-10 16:21:55 UTC hello@padlet.com https://padlet-uploads.storage.googleapis.com/363938527/7486d9adb0f2355c3368b7224e9190ae/download.jpg paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358941235 Sickle Cell is an inherited disease that causes crescent shaped red blood cells that can not properly flow through the blood vessels causing episodes of pain. 

]]> 2019-05-10 16:16:00 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358941235 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358941827 Sickle cell is diagnosed through the hematocrit levels in the body. 

• Hematocrit is the proportion of the blood that consists of red blood cells. 

The components of blood are: 

• Blood plasma - the liquid that the blood cells are carried in 
• Erythrocytes - red blood cells that carry oxygen 
• Leukocytes - white blood cells that protect against sickness 
• Thrombocytes - platelets that clot wounds 

]]> 2019-05-10 16:17:21 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358941827 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358942170 Effects of having Sickle Cell:

• Anemia: the lack of enough blood cells to provide oxygen which causes symptoms such as fatigue and dizziness 
• Potential for organ damage such as the: liver, eyes, and kidneys

Treatments: 

• Medication such as antibiotics as well as blood transfusion 

]]> 2019-05-10 16:18:06 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358942170 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358942424 Anna Garcia was taken to the hospital when she was 14 months old, she was experiencing breathing problems, pain, and was extremely lethargic 

• Temperature: 101.4
• Pulse: 175 bpm
• Respiration Rate: 40 bpm

]]> 2019-05-10 16:18:39 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358942424 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358942825 Physical Exam Notes:

• Respiratory Exam: Her breathing was abnormal, respiratory rate is slightly high, and she is short of breath
• Skin Exam: pale skin, nails, and lips  
• Gastro-Intestinal: She has not had an appetite, has a bright red diaper rash, been having diarrhea for two days 
• Cardiovascular: heart rate is rapid and above normal range
• Urinary: higher urine output than normal

]]> 2019-05-10 16:19:32 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358942825 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943087 Tests Performed:

• CBC: red blood cell count reduced levels; white blood cell count increased  
• Hematocrit: lower than normal hematocrit- 20% 
• Blood oxygen: lower than normal levels 
• CT scan: abnormal spleen, indicative of splenic sequestration
• Sickle cell test: positive for sickle cell anemia 

]]> 2019-05-10 16:20:12 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943087 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943450 2019-05-10 16:21:02 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943450 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943453

The genetic code is a triplet code, with codons of three mRNA bases coding for specific amino acids 

Each triplet codon specifies only one amino acid

Sickle cell is caused by a mutated gene, the gene affected is hemoglobin 

Hemoglobin is a protein in red blood cells that carry oxygen through the body 

It has four subunits; it is made by combining two B-globin proteins and two A-globin proteins

]]> 2019-05-10 16:21:03 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943453 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943741 2019-05-10 16:21:42 UTC https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943741 paige_snyder1 https://padlet.com/paige_snyder1/7k3i0ep3oi2q/wish/358943745

Sickle cell mutation is carried on chromosome 11 

It is a recessive gene, so it needs to have two alleles for the gene to be mutated 

Mitosis is a process that our body uses to replicate cells

It results in the formation of two cells having 46 chromosomes that are identical to the original 46 chromosomes 

Meiosis is a process used to produce sex cells 

It results in the formation of four sex cells, each having 23 chromosomes which is half the number of chromosomes in the original cell 

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