https://padlet.com/2021logankeener/7fi2gzuamtmk It's a X chromosome linked disease. en-us 2017-11-16 12:50:26 UTC 2023-01-24 04:46:02 UTC hello@padlet.com 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207639912 ALD is caused by an abnormality in the ABCD1 gene located on the X chromosome. This gene abnormality leads to the production of an abnormal ALDP protein in a part of the cell called the peroxisome, and is responsible for breaking down very long chain fatty acids. The accumulation of very long fatty acids damages the protective covering of nerves, resulting in neurological problems.]]> 2017-11-16 13:28:38 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207639912 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207640905 https://rarediseases.org/rare-diseases/adrenoleukodystrophy/

Adrenoleukodystrophy. (2017, October 31). Retrieved November 17, 2017, from https://en.wikipedia.org/wiki/Adrenoleukodystrophy

Baron, A. (n.d.). Peroxisomes: Definition, Structure & Functions. Retrieved November 17, 2017, from http://study.com/academy/lesson/peroxisomes-definition-structure-functions.html]]> 2017-11-16 13:30:56 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207640905 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207642625

Addison Disease with Cerebral Sclerosis

Adrenomyeloneuropathy

ALD

AMN

Bronze Schilder Disease

Melanodermic Leukodystrophy

Schilder Disease

Siemerling-Creutzfeldt Disease

Sudanophilic Leukodystrophy

X- ALD

]]> 2017-11-16 13:34:54 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207642625 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207648773 The abnormal adrenal function is treated with corticosteroid replacement therapy. Bone marrow transplantation has been successful in individuals who are in the early stages of ALD. Affected individuals can benefit from supportive care from psychologists, educators, physical therapists, urologists, and family and vocational counselors. Genetic counseling is recommended for affected individuals and their family members.]]> 2017-11-16 13:47:18 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/207648773 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208073568 2017-11-17 12:57:02 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208073568 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208074337 ALD is caused by mutations in ABCD1, located at Xq28 and demonstrates X-linked recessive inheritance. The gene ABCD1 encodes a peroxisomal membrane transporter which is responsible for transporting very long chain fatty acid substrate into the peroxisomes for degradation.]]> 2017-11-17 12:59:07 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208074337 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208075223 Peroxisomes have two functions: break down fatty acids to be used for forming membranes and as fuel for respiration; and transfer hydrogen from compounds to oxygen to create hydrogen peroxide and then convert hydrogen peroxide into water.]]> 2017-11-17 13:01:42 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208075223 2021logankeener https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208076873 2017-11-17 13:06:12 UTC https://padlet.com/2021logankeener/7fi2gzuamtmk/wish/208076873