Kapitel 16- Spørgsmål 1: Manipulation of the immune system by Malene Hvid https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf Gruppe 1: Biologisk behandling ved autoimmune sygdomme: Hvilke typer af targets? Hvordan virker behandlingen? Gruppe 2: Biologisk behandling ved cancer sygdomme: Hvilke targets, hvordan virker behandlingen? en-us 2021-09-21 08:14:21 UTC 2026-01-20 01:47:35 UTC hello@padlet.com Gruppe 2 https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920131032 Possible targets:
PD-1
PD-L1
CTLA4

treatmeants:
Rituximab
CAR-T
Bispecifik antigen receptors

]]> 2021-11-30 11:21:38 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920131032 Tumor antigener til biologisk behandling https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920133552 2021-11-30 11:23:32 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920133552 Targets til behandling af autoimmune sygdomme https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920137039 Inflammatoriske cytokiner, fx:
- TNF-alfa (rheumatoid artrit, Chrons sygdom)
- IL-17 (behandling af psoriasis)
- IL-6 (behandling af rheumatoid artrit)
- IL-1 (rheumatoid artrit) 

Targets kan både være cytokinet samt receptorer. Lægemidlerne virker ved at binde som en antagonist og blokere cytokinets aktivitet (anti-inflammatorisk)]]> 2021-11-30 11:26:08 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920137039 Biologisk behandling https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920137678 Biologisk behandling kan være:
Antistoffer og rekombinante receptorer
Antistofferne og de rekombinante receptorer vil fungere som antagonister overfor fx cytokiner, hvilket vil inhibere signal transduktion. ]]> 2021-11-30 11:26:35 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920137678 https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920137981 2021-11-30 11:26:51 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920137981 Metoder der bruger tumor-specific monoclonale antistoffer https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920138249 2021-11-30 11:27:05 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920138249 Gruppe 2: Monoklonale targets i terapeutiske trials https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920138421 2021-11-30 11:27:14 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920138421 Gruppe 1 https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920138525 - Blokering af TNF-a (med antistoffer el. rekombinant TNF-receptor)
- Blokering af eks. IL-1, IL-6 el. IL-17 (antistoffer el. rekombinante proteiner)
- Checkpoint inhibitorer?]]> 2021-11-30 11:27:18 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920138525 PD-L1 inhibering https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920142667 2021-11-30 11:30:32 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920142667 Biologisk behandling mod cancer https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920144237 Checkpoint inhibitorer blokerer et inhibitorisk signal mod 
- PD-1
- CTLA-4

CAR-T celler: T-celler udtages fra patienten for at blive modificeret, så deres T-celle receptor er specifik overfor cancercellerne

Monoklonale antistoffer: angriber tumor antigener


]]> 2021-11-30 11:31:48 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920144237 CTLA-4 inhibering https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920144837 https://nci-media.cancer.gov/pdq/media/images/776560.jpg]]> 2021-11-30 11:32:17 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920144837 Corticosteroider https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920148085 Anti-inflammatorisk lægemiddel ]]> 2021-11-30 11:34:43 UTC https://padlet.com/malene_hvid1/6j29nq8mfquj7jaf/wish/1920148085