"Protein Interactions: Explain the Molecular Mechanisms behind Antibodies' extraordinary bindind Specificity and Affinity." by Albina Abraham

Vanoss.C.J.,Good.R.J.,Chaudhury.M.K.,1996." Natureof the antigen-antibody interaction": Journal of Chromatography,376,111-119

albinaabraham — 2015-11-03 15:17:42 UTC

How the antibodies and antigens interact using different bonds. the bonds involved are hydrogen bonds, coulomb bonds, van der waals, Ca2+ bridging and hydrophobic interactions.

Ross.P.D.,Subramanian.S., 1981. "Thermodynamics of protein association reaction: Forces contributing to stability": Biochemistry, 20, 3096-3102.

albinaabraham — 2015-11-04 16:29:19 UTC

Thermodynamics of antibody interactions.

Figure 1: Biologyexams4u,2015. How antibody works and inactive antigen? Antigen-antibody interaction[Online] available at: http://www.biologyexams4u.com/2012/11/antigen-antibody-interaction.html#.VjaApoTA4_U [Accessed: 1st November 2015

albinaabraham — 2015-11-04 16:32:10 UTC

The structure of an antibody.

Frank.S.A.,2002. Immunology and evolution of infectious disease. Princeton: Princeton university press.

albinaabraham — 2015-11-04 16:35:03 UTC

Describes the specificity and cross reactivity of the antibodies.

Goding.J.W.,1996. "The antibody response": Monoclonal antibodies, 3, 7-25.

albinaabraham — 2015-11-04 17:02:48 UTC

Background information on the discovery of antibody and its specificity by Ehrlich.

Bhat.N.T.,et.al.,1994. "Bound water molecules and conformational stabilisation help mediate an antigen-antibody association": Immunology, 91, 1089-1093

albinaabraham — 2015-11-04 17:08:54 UTC

How titration calorimetry and X-ray cristallography was used to determine the thermodynamics behind the binding interactions.

Fu.E.,et.al.,2015."Protein dynamics, entropy & function"[Online]. Available at: http://www.med.upenn.edu/wandlab/research/protein_interactions.html [Accessed on 27th October 2015]

albinaabraham — 2015-11-04 17:32:04 UTC

The role that Entropy plays in modulating the free energy required for the complex formation between antibody and antigen.

albinaabraham — 2015-11-04 18:50:29 UTC

Rudnick.S. I.,Adams.G.P.,2009."Antibody and avidity in antibody-based tumor targeting": Cancer biotherapy and radio pharmaceuticals,24(2),155-161.

albinaabraham — 2015-11-05 17:12:03 UTC

Compares the distribution of tumor specific and non-specific radio labelled antibodies.