Absorption and Bioavailability by Berv Lopez https://padlet.com/bervlopez/6durp5ohb19u9tfq en-us 2020-05-22 02:10:48 UTC 2024-10-09 11:01:56 UTC hello@padlet.com Absorption and Bioavailability bervlopez https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/589894184 Absorption
  • Absorption is the movement of a drug from its site of application into the bloodstream.
  • Except when a drug is directly applied to, or in the vicinity of, the target site, absorption must occur for a drug to exert its therapeutic effect.
Example: topical creams
  • Drug absorption is very significant in developing new drugs and establishing the therapeutic equivalence of new formulations or generic versions of existing drugs.

Factors Affecting Drug Absorption:
1. Physicochemical properties of drug example: lipid solubility, molecular size, degree of ionisation
2. Drug formulation
example: tablets, capsules and solutions
3. Route of Administration
example: oral, buccal, sublingual, rectal, IV
4. Rate of gastric emptying time



]]> 2020-05-23 00:28:30 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/589894184 References: https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/592299876 1. Abula, T. (2004). Pharmacology. Retrieved May 26, 2020, from http://frida.unito.it/wn_media/uploads/pharmaco_1432836510.pdf
2. Cook, D. (2019). Liposomal Vitamin C vs Regular Vitamin C. Retrieved May 26, 2020, from https://www.dougcookrd.com/vitamin-c-supplement/
3. Gordon, M. (n.d.). Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics. Retrieved May 26, 2020, from https://www.pharmacology2000.com/General/Pharmacokinetics/kinobj1F.htm
4. Katie. (2016). Which Form of Vitamin C is Best? - VitaVibes Blog. Retrieved May 26, 2020, from https://www.vitacost.com/blog/vitamins-supplements/supplements/which-form-of-vitamin-c-is-best.html
5. New Zealand Data Sheet for Panadol Optizorb (Caplets/Tablets) retrieved from https://www.medsafe.govt.nz/profs/Datasheet/p/Panadoloptizorbtabcaplets.pdf 
6. New Zealand Data Sheet for Paracetamol 10mg/ml solution for injection  retrieved from https://www.medsafe.govt.nz/profs/Datasheet/p/paracetamolAFTinf.pdf
7.  What is Bioavailability and Bioequivalence retrieved from https://bpac.org.nz/BPJ/2009/generics/bio.aspx 
 




]]> 2020-05-25 06:27:29 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/592299876 Bioavailability lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/592317911
  • It is the rate and amount of drug that is absorbed from a given dosage form and reaches the systemic circulation following non-vascular administration.
  • The fraction of the systemic circulation. It varies  for other routes depending  on  absorption, first hepatic metabolism etc . 
  • It is important to know the manner in which a drug is absorbed. The route of administration largely determines the latent period between administration and onset of action.
  •  When the drug is given IV, the bioavailability is 100%.  

    • ]]>     2020-05-25 06:41:39 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/592317911     Example: bervlopez https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/592326660 Comparison of Different Dosage form of Paracetamol]]> 2020-05-25 06:48:22 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/592326660 ISHAN SHARMA ishans18072000 https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593677335
    All generic medicines in New Zealand are approved by Medsafe and have been shown to be bioequivalent to innovator medicines, according to internationally accepted criteria and standards.1

    "This means that any differences in bioavailability between generic and innovator medicines are not clinically significant."

    ]]>     2020-05-25 21:46:52 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593677335     Example: lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593821060 Comparison of Different Brands on Vitamin C ]]> 2020-05-26 00:49:30 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593821060 Nutra-Life Ester C with Bioflavonoids lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593855702 2020-05-26 01:31:26 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593855702 Healtheries Vitamin C lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593861578 2020-05-26 01:37:45 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593861578 Lypo-Spheric Vitamin C lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593862514 2020-05-26 01:38:36 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593862514 Paracetamol (Standard Immediate Release Tablet) lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593873470 2020-05-26 01:51:46 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593873470 Paracetamol (Optizorb) lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593874264 2020-05-26 01:52:45 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593874264 Major factors that reduce bioavailability to less than 100%: lanaisabelli https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593881354 1. Incomplete absorption
    2. First-pass effect (liver metabolizes drug before drug reaches systemic circulation)

    ]]>     2020-05-26 02:00:31 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593881354     Lana Dalisay CH-19-0267 Amandeep CH-19-0345 Ishan CH-20-0479 Berv CH-19-0343 bervlopez https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593961426 2020-05-26 03:49:58 UTC https://padlet.com/bervlopez/6durp5ohb19u9tfq/wish/593961426