https://padlet.com/gngraci/697kp6ax8qjj Week 14 Small Group Assignment en-us 2018-04-30 20:56:54 UTC 2025-05-02 23:22:45 UTC hello@padlet.com gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256702416 2018-04-30 21:00:07 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256702416 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256702463 A genetic defect occurs in the hemoglobin protein that alters the shape of red blood cells.]]> 2018-04-30 21:00:24 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256702463 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256702840 Valine is substituted for glutamic acid in the hemoglobin protein, causing disruptions in the beta polypeptide chains. This creates Hemoglobin "S" instead of normal Hemoglobin "A."]]> 2018-04-30 21:02:28 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256702840 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256703350 As a result of Hemoglobin "S" red blood cells become clumped and sickled instead of concave. ]]> 2018-04-30 21:04:55 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256703350 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256703471 The sickled cells lead to blocked blood flow, ischemia, and extreme pain.]]> 2018-04-30 21:05:32 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256703471 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256703961 2018-04-30 21:07:52 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256703961 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256704162 2018-04-30 21:08:53 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256704162 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256704195 2018-04-30 21:09:02 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256704195 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256704973 Sickled red blood cells often hemolyze or burst, causing an increase in ruptured red blood cells to be recycled in the spleen. Normally, RBC are recycled every 90-120 days, but sickle cells last less than 3 weeks, this causes lots of RBC to build up in the spleen. The body often cannot catch up, leading to RBC getting stuck in the spleen, making the spleen unusable.]]> 2018-04-30 21:12:14 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256704973 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256705482 Sickle cell anemia can be inherited as homozygous recessive or heterozygous recessive.]]> 2018-04-30 21:14:30 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256705482 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256705863 Sickle Cell Disease (Anemia)]]> 2018-04-30 21:16:14 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256705863 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256705920 Sickle cell trait (carrier)]]> 2018-04-30 21:16:29 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256705920 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256706495 If someone is a carrier of sickle cell disease, they do not show symptoms but may carry the disease to their child if the other parent is also a sickle cell carrier.]]> 2018-04-30 21:19:47 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256706495 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256706691 Those with sickle cell disease DO manifest symptoms and can carry the disease to their child if the other patient is a carrier (heterozygous) or has sickle cell disease (homozygous)]]> 2018-04-30 21:20:46 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256706691 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256706854 oo]]> 2018-04-30 21:21:46 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256706854 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256707030 2018-04-30 21:22:37 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256707030 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256707111 Sickling can occur in the blood vessels of the lungs. This can cause lung tissue damage and poor tissue perfusion resulting in poor gas exchange. It often causes chest pain and is a differential diagnosis for MI.]]> 2018-04-30 21:23:06 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256707111 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256707425 2018-04-30 21:25:00 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256707425 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256707591 2018-04-30 21:25:52 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256707591 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256707767 2018-04-30 21:26:55 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256707767 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256707904 2018-04-30 21:27:43 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256707904 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256707947 2018-04-30 21:27:54 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256707947 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708044 2018-04-30 21:28:27 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708044 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708058 2018-04-30 21:28:32 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708058 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708236 Sickling of RBC can cause complications in the lungs and spleen.]]> 2018-04-30 21:29:38 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708236 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708415 2018-04-30 21:30:39 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708415 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708438 2018-04-30 21:30:44 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708438 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708480 2018-04-30 21:30:54 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708480 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708626 2018-04-30 21:31:45 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708626 gngraci https://padlet.com/gngraci/697kp6ax8qjj/wish/256708804 Specific outcomes for each genetic mutation is show to the right.]]> 2018-04-30 21:32:57 UTC https://padlet.com/gngraci/697kp6ax8qjj/wish/256708804