Research sources by Tom Quirk https://padlet.com/tomquirkk/52a72jtqz7nd "How have immunological and molecular techniques informed diagnosis and treatment of Chronic Myeloid Leukaemia?" en-us 2017-11-05 13:19:47 UTC 2024-07-14 17:23:15 UTC hello@padlet.com Haematology at a glance (Fourth Edition) - Atul B. Mehta, A. Victor Hoffbrand tomquirkk https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203624183
  • Very basic
  • Introduces basic mechanisms of haematological malignancies 
  • Provides a basic overview of Chronic Myeloid Leukaemia 
    • Pathophysiology 
    • Clinical features 
    • Treatment
    • ]]>     2017-11-05 13:25:44 UTC https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203624183     Chronic myeloid leukaemia seminar tomquirkk https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203832051 (Apperly, Jane F., 2015. Chronic myeloid leukaemia. The Lancet, 285, 1447-1459)
    • Published in The Lancet, a peer-reviewed medical
    • Introduces and goes into some detail on:
      • Pathophysiology of CML
      • Diagnosis of CML
    • Goes into great detail on treatment of CML
    ]]>     2017-11-06 12:27:25 UTC https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203832051     Chronic myeloid leukaemia tomquirkk https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203968578 (Lavallade, Hughes, 2013. Chronic myeloid leukaemia. Medicine, 41 (5), 275-277)
    • Published in medicine, a well known peer-reviewed journal
    • Goes into brief detail on treatment of CML
    • Gives definitions of the phases (i.e. chronic, accelerated, blastic) 
    ]]>     2017-11-06 16:22:25 UTC https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203968578     FISH used in diagnosis tomquirkk https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203974382 (Poonam, J., et al, 2012. FISH patterns of BCR/ABL1 fusion in chronic myelogenous leukaemia at diagnosis. Indian journal of pathology and microbiology, 55 (3), 347-351)
    • Talks about the diagnosis of CML using fluorescence in situ hybridisation (FISH)
    ]]>     2017-11-06 16:31:43 UTC https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203974382     Formation of the Philadelphia chromosome tomquirkk https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203985720 https://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq 
    • Clearly shows how translocation of chromosomes 9 and 22 produce the Philadelphia chromosome 
    ]]>     2017-11-06 16:49:25 UTC https://padlet.com/tomquirkk/52a72jtqz7nd/wish/203985720