https://padlet.com/rsdlily/50pcfji1norscf45 Module 2: Dr Rania en-us 2021-12-16 02:53:09 UTC 2023-04-06 13:04:14 UTC hello@padlet.com rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959948655 - Briefing session with my pretty supervisor, Dr Rania
- I was introduced to the Drugbank and preADMET tool that will be used in our study
- Dr explaining on how this study should be resolved based on the lab sheet provided
- Dividing group members into subgroup for each compound and objective
- Share research article in the whatsapp group among the members]]> 2021-12-22 04:41:59 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959948655 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959954344 - Read a few articles regarding the covid vaccine and the active compound in it also with the mechanism.
- Each member start to propose several compounds to be used in this study based on our reading]]> 2021-12-22 04:48:52 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959954344 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959958358 - having a meeting to discuss on the proposed compounds and choose the one that we want to use in the study
- discussed on the targeted organ for each compound
- distribute the task on preparing the proposal]]> 2021-12-22 04:53:38 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959958358 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959961945 - having a weekly session with my pretty supervisor, Dr Rania
- Dr Rania reviewed our proposal and gave some comments on it
- My group is trying to find another type of compound to replace the formaldehyde since the justification for this compound is not strong enough
- I am fixing the problem statements based on Dr comments
- We found a new compound to replace the formaldehyde, which is DSPC]]> 2021-12-22 04:57:54 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1959961945 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1967299486 - finding a few articles/research papers regarding the DSPC.
- Do further research to confirm whether the DSPC in the COVID-19 vaccine causes any allergic reaction (anaphylaxis) to the recipients.
- Explore the compound's detail (DSPC) on the DRUGBANK online.]]> 2021-12-29 03:44:51 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1967299486 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1967373755 - start to work on the prediction of the compound (DSPC) based on the absorption, distribution, metabolism, excretion, and toxicities (ADMET) using the prediction tool, pre-ADMET.]]> 2021-12-29 05:34:38 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1967373755 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1969521183 - start to analyze the result of the ADMET of compound (DSPC)
- determine which parameters should be considered regarding our focus which is anaphylaxis]]> 2021-12-31 07:45:18 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1969521183 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1974813217 - Have a meeting with group members to distribute the task among us for weekly report update to Dr. Rania
- The distribution of tasks was among the subgroup members. Each subgroup consist of 3 members and we decided to divide it into AD, ME, and toxicity 
- Start to tabulate the result of prediction and draft the report
- But somehow, my subgroup having a problem with our current compound (DSPC) since there is not so much research paper available on the internet

]]> 2022-01-04 18:06:34 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1974813217 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1974837348 - My subgroup members planning to change our current compound to another which is Aluminum Hydroxide.
- This is because of the lack of availability of research papers regarding DSPC compounds which limited our justification for each parameter regarding the anaphylaxis issue.
- As we got approval from Dr. Rania, I start to do the prediction on our new compound and tabulate it again.
- Among all of the parameters, I determined which parameters should be included and excluded based on the research paper I found on the internet,
- I also start to draft again the report.]]> 2022-01-04 18:18:39 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1974837348 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1982006360 - Based on the previous session with Dr Rania, I need to do further research on the toxicity parameters of Aluminum Hydroxide on how it is related to the occurring of anaphylaxis or any allergy reactions.
- Based on my research, I tend to include some of the parameters in consideration related to the anaphylaxis or allergy reaction which was previously excluded from my prediction.
- Not only that, based on my reading of a few papers, I got some idea of the value that I got from the toxicity result. In my opinion, the number is about the EC50 value which is the concentration of a compound where 50% of its maximal effect is observed.]]> 2022-01-09 02:28:48 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1982006360 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1982307190 - Have a meeting with the group members to review and discuss based on the comments from Dr Rania previously.
- We decided to revaluate our parameters for each component to standardize it.
- Mostly, all of us need to do more research and find a strong justification for each parameter related to anaphylaxis.]]> 2022-01-09 13:11:43 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1982307190 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1993630712 - compile all the included parameters in prediction of pre-ADMET result of Aluminum Hydroxide within my subgroup]]> 2022-01-15 16:14:06 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1993630712 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1998558207 - Based on the previous session with Dr Rania still not satisfy with the justification on metabolism and excretion prediction.
- Thus, my subgroup decided to focus more on those two elements.]]> 2022-01-18 17:30:35 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1998558207 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1998563193 - search for articles/research paper related with metabolism and excretion elements.
- each of us update our findings in the WhatsApp group so that there will be no redundant information.]]> 2022-01-18 17:32:40 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1998563193 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/1998567391 - update my findings on my subgroup online google document to justify the included parameters.]]> 2022-01-18 17:34:28 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/1998567391 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/2012736658 - dividing the task on the slide presentation & the final report ]]> 2022-01-26 04:33:57 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/2012736658 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/2012738958 - finish up with subgroup task so that we can come out with a conclusion to determine which compound is the most toxic.
- prepare the slide for presentation]]> 2022-01-26 04:36:10 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/2012738958 rsdlily https://padlet.com/rsdlily/50pcfji1norscf45/wish/2012740811 - checking the slide with Dr Rania and proceed with the recording of presentation video.
- submit the compiled presentation video to the panels.]]> 2022-01-26 04:37:54 UTC https://padlet.com/rsdlily/50pcfji1norscf45/wish/2012740811