BPS2042 Workshop (Week 8) by Ong Yong Sze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d Preclinical PK Study en-us 2025-09-15 10:48:17 UTC 2025-09-17 02:47:20 UTC hello@padlet.com https://padlet.net/icons/8.0/svg/1f60d.svg How much drug substance in total? Remain the same dosage? ongyongsze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585247538 2025-09-15 10:51:50 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585247538 What time points would be sampled when dosing SC and orally? ongyongsze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585247773 2025-09-15 10:52:00 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585247773 How many rats for all three treatments? ongyongsze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585247911 2025-09-15 10:52:08 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585247911 Can you do a cross-over study? Or different animals for each treatment? ongyongsze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248030 2025-09-15 10:52:17 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248030 What volume for IV injection if solubility is 10 mg/mL ongyongsze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248232 2025-09-15 10:52:26 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248232 What is the maximum volume for oral gavage in rats? ongyongsze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248403 2025-09-15 10:52:34 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248403 What is the maximum injection volume for SC administration in rats? ongyongsze https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248630 2025-09-15 10:52:42 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3585248630 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588709158 Fast clearance

]]> 2025-09-17 01:32:03 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588709158 too much spacing between sample collection https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588709440 2025-09-17 01:32:12 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588709440 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588710544 Need more intervals?

]]> 2025-09-17 01:32:41 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588710544 experiment shouldve been let to run longer ? https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588712921 2025-09-17 01:33:51 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588712921 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588714163 there is too less data points, graphs looks very spaced out

]]> 2025-09-17 01:34:21 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588714163 No error bars for last 2 conc? https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588715638 2025-09-17 01:35:09 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588715638 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588744170

Add More Time Points Shortly After Dosing


]]> 2025-09-17 01:48:22 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588744170 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588744216 0, 2, 5, 10, 15, 30, 45, 60, 90

]]> 2025-09-17 01:48:23 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588744216 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588745233 2025-09-17 01:48:52 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588745233 4, 8,12, 16,20,24, 48,96,120 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588746371 2025-09-17 01:49:23 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588746371 1,2,3,4,5,10,15,30,60,90,120 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588746530 2025-09-17 01:49:28 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588746530 Grrrrtt https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588747033 0, 4, 8, 16, 24, 48, 72, 144

]]> 2025-09-17 01:49:44 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588747033 1 2 3 4 5 15 30 60 120 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588747039 2025-09-17 01:49:44 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588747039 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588747560 0,1,2,3,6,12,24,48,96..

]]> 2025-09-17 01:50:00 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588747560 microsampling to reduce volume of blood taken https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588867436 2025-09-17 02:43:20 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588867436 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588868328 replicate sampling


]]> 2025-09-17 02:43:37 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588868328 https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588870850 serial sampling: use larger animals and take multiple samples from the same animal (ethical if blood volume limits are respected)

]]> 2025-09-17 02:44:47 UTC https://padlet.com/monashmalaysia1/3qr0begbzy360i9d/wish/3588870850