Specific focus on Risk of Bias (ROB)

Very comprehensive, 'deep-dive' and granular appraisal analysis tool

Detailed guidance on decision-making both in written and visual form through use of diagrams in cribsheet

More detailed assessment of bias domains and clearer guidance compared to its predecessor

Helps to differentiate gradually between yes - probably yes - probably no - no - no information

Very appropriate for detailed analysis of quantitative methodology in particular

Due to detail and depth, the tool seems can be resource- and time-intensive, requiring a lot of attention to detail

Detail may challenge usability at the expense of time spent on it

This may pose a challenge for researchers esp. single researchers such as DClins trainees, and when summarising many papers

Adherence to guidance depending on researchers' ablity to use it and stick closely to it

Useful approach for small number of appraised papers, but challenging for a larger number of papers