Sickle Cell Disease by Kayla Cote https://padlet.com/kncote/3nnj8ifgu8fl Small Group en-us 2018-04-30 18:47:59 UTC 2026-01-04 18:25:22 UTC hello@padlet.com kncote https://padlet.com/kncote/3nnj8ifgu8fl/wish/256663076 Sickle Cell Disease ]]> 2018-04-30 18:48:52 UTC https://padlet.com/kncote/3nnj8ifgu8fl/wish/256663076 Pathophysiology kncote https://padlet.com/kncote/3nnj8ifgu8fl/wish/256663573 There is a genetic mutation in sickle cell disease which causes synthesis of hemoglobin (Hgb) that is fragile and has it is inefficient in carrying oxygen around the body. When conditions such as the following; hypoxia, stress, infection, or dehydration occur the sickle cell hemoglobin will polymerize and become distorted in shape which causes the red blood cells to change into a crescent or sickle- shaped cell. The red blood cells are capable of reoxygenating and resuming a normal condition but when frequent episodes of sickling occur these red blood cells remain distorted. ]]> 2018-04-30 18:50:00 UTC https://padlet.com/kncote/3nnj8ifgu8fl/wish/256663573 How mutation for Sickle Cell disease and Sickle Cell Trait are inherited kncote https://padlet.com/kncote/3nnj8ifgu8fl/wish/256673389 The genetic mutation that occurs is either heterozygous which means that the individual carries two different alleles for SCD or homozygous meaning the individual carries two different copies of the SCD allele. The inherited sickle cell disease causes one of the beta polypeptide chain of hemoglobins structure to be abnormal because one of the amino acids in the chain (valine) is substituted for glutamic acid. When this occurs, it causes the normal hemoglobin molecule Hgb A, to turn into Hgb S which is the primary type of hemoglobin in sickle cell disease]]> 2018-04-30 19:14:38 UTC https://padlet.com/kncote/3nnj8ifgu8fl/wish/256673389 How Sickle Cell Disease causes Splenic Sequestration crisis kncote https://padlet.com/kncote/3nnj8ifgu8fl/wish/256674510 Because of the high amount of lysed red blood cells that must be processed by the spleen in SCD it can cause the spleen to become ischemic and dysfunction. Which can lead to splenic sequestration crisis which occurs because red blood cells get stuck in the spleen making it enlarge very rapidly. Because of the dysfunction that can happen in the spleen with this crisis, it can lead to fewer red blood cells circulating in the blood which will cause anemia. ]]> 2018-04-30 19:17:44 UTC https://padlet.com/kncote/3nnj8ifgu8fl/wish/256674510 How Sickle Cell Disease causes Acute Chest Syndrome kncote https://padlet.com/kncote/3nnj8ifgu8fl/wish/256675075 Acute chest syndrome occurs when the sickling (production of sickle shaped red-blood cells) occurs in the blood vessels of the lungs. This causes the lung tissue to become damaged leaving it unable to exchange oxygen. It often occurs a few days following a painful crisis. It can cause chest pain, tachypnea, fever, cough, and low arterial saturation (due to abnormal changes in hemoglobin). 
 
 
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