Haematology by https://padlet.com/anne_marie_harr/haematology Post questions here about the haematology section of the module en-us 2017-12-11 13:17:00 UTC 2025-09-29 07:55:37 UTC hello@padlet.com Anaemia https://padlet.com/anne_marie_harr/haematology/wish/215000853
Will the main focus for the heamtology section of the exam be on the type of anemia (not specifically, but the broad category under which it falls) covered in the coursework?
Answer The haematology questions on the exam could cover any of the haematology content]]> 2017-12-11 13:46:44 UTC https://padlet.com/anne_marie_harr/haematology/wish/215000853 Microcytic https://padlet.com/anne_marie_harr/haematology/wish/215033390 Microcytic RBSs are due to the excess division of the RBC precurser cells. But why does this happen in iron defficiency? 
Answer Please see the answer to the same question next door

]]> 2017-12-11 14:45:18 UTC https://padlet.com/anne_marie_harr/haematology/wish/215033390 Exam https://padlet.com/anne_marie_harr/haematology/wish/215041254 Is section A mainly on thehaematology lectures? can you supply us with more exam style questions due to the exam paper changing this year? 
Section A will be a case study. I will put more information on this in the Assessment section. We will put a few more examples up]]> 2017-12-11 14:57:42 UTC https://padlet.com/anne_marie_harr/haematology/wish/215041254 How is iron absorption regulated by gene expression of ferritin and hepcidin? https://padlet.com/anne_marie_harr/haematology/wish/215330827 Answer Hepcidin is expressed  in response to iron stores (as well as some other factors), when expressed it reduces absorption of iron by removing ferroportin from the membrane. Ferritin is expresed when there is iron to store - it is a storage protein not a transport or abosrption protein. A paper on this was recommended in the lecture slides]]> 2017-12-12 09:48:02 UTC https://padlet.com/anne_marie_harr/haematology/wish/215330827 How is iron absorption regulated by gene expression of hepcidin and ferritin? https://padlet.com/anne_marie_harr/haematology/wish/215331562 Answered elsewhere on this wall]]> 2017-12-12 09:50:14 UTC https://padlet.com/anne_marie_harr/haematology/wish/215331562 Why are cells smaller in iron deficiency? https://padlet.com/anne_marie_harr/haematology/wish/215336639
Answer The concentration of haemoglobin is one of the factors in determining how many time the cells will divide. When this has reached a threshold concentration no further division takes place. In iron deficiency it takes longer to reach this thus the cell can udnergo a few more divisions]]> 2017-12-12 10:04:45 UTC https://padlet.com/anne_marie_harr/haematology/wish/215336639 Covering relevant material for the exam https://padlet.com/anne_marie_harr/haematology/wish/215355216 If we go over the lectures 1-60, we'd most likely forget the first lecture by the time we finish. What is your take on the most effective approach to both digest and understand the overarching concepts, so that we can best prepare ourselves for the exam?
Answer revision is an ongoing process, I hope that you are already clear on material from the early lectures in the module - I am not sure what you mean by 1-60 here. However, there are various strategies to help information to stick - test yourself, talk and explain things to others, practice writing answers (you can make your own questions up to test yourself on areas you find difficult), use diagrams or flow charts for key ideas and processes. There is no more content  here than in any other 20 credit module you have revised for so what worked in the past should work here. Also there is Study Support available within the university]]> 2017-12-12 11:19:08 UTC https://padlet.com/anne_marie_harr/haematology/wish/215355216 Do we need to know the cycling of folic acid between the various co enzymes forms ? https://padlet.com/anne_marie_harr/haematology/wish/215742255 Answer Do you mean between DHF/THF etc? if so then this is not a vital piece of information. You need to know why folate is important]]> 2017-12-13 11:37:43 UTC https://padlet.com/anne_marie_harr/haematology/wish/215742255 Why are megaloblastic anemia characteristic of large cells? Why do they have a mature cytoplasm and absent nucleus? https://padlet.com/anne_marie_harr/haematology/wish/215756351 Answer The deficiency of folate and or B12 interferes with nucleotide base synthesis, this means that nuclear and cytpoplasmic development get out of step and the cell undergoes slightly fewer divisions]]> 2017-12-13 12:40:33 UTC https://padlet.com/anne_marie_harr/haematology/wish/215756351 is section A a case study on the exam? https://padlet.com/anne_marie_harr/haematology/wish/215852329 Answer Yes, please see the example paper for this. I will try to put up more examples over Christmas]]> 2017-12-13 16:03:23 UTC https://padlet.com/anne_marie_harr/haematology/wish/215852329 can you please put the reveision questions up https://padlet.com/anne_marie_harr/haematology/wish/216431233 2017-12-15 10:41:30 UTC https://padlet.com/anne_marie_harr/haematology/wish/216431233 Could you please put up the slides from the revision session? Thanks https://padlet.com/anne_marie_harr/haematology/wish/216435781 2017-12-15 11:00:37 UTC https://padlet.com/anne_marie_harr/haematology/wish/216435781 Do we need to learn all the different types of translocations you have mentioned in lectures or can we describe a few? Also do we need to know the prognosis of each of these? https://padlet.com/anne_marie_harr/haematology/wish/216518904 Ans: As stated in lectures you do not need to learn all translocations, however, being able to give some examples may be useful]]> 2017-12-15 15:37:49 UTC https://padlet.com/anne_marie_harr/haematology/wish/216518904 Haemolytic anaemia https://padlet.com/anne_marie_harr/haematology/wish/216638244 Why are iron levels low in intravascular haemolytic anaemia but high in extravascular haemolytic anaemia?

Ans: in intravascular haemolysis some iron may be lost as haemoglobin in the urine. In extravascular the iron is normally retrieved and recycled as per the normal process]]> 2017-12-15 21:47:36 UTC https://padlet.com/anne_marie_harr/haematology/wish/216638244 Could you put up the example questions from the revision session please https://padlet.com/anne_marie_harr/haematology/wish/216762501 2017-12-17 14:52:53 UTC https://padlet.com/anne_marie_harr/haematology/wish/216762501 I'm worried about the case study on the exam. will it be obvious what the condition is? https://padlet.com/anne_marie_harr/haematology/wish/216770588
Ans: As explained in sessions the case study on the exam will be much simplified compared to the coursework. You have example to look at and we will put more up during this week.]]> 2017-12-17 16:09:15 UTC https://padlet.com/anne_marie_harr/haematology/wish/216770588 Can I define anaemia as a reduction of number of RBC leading to reduction in O2 delivered to tissues? https://padlet.com/anne_marie_harr/haematology/wish/216780710 Ans:Yes]]> 2017-12-17 17:29:21 UTC https://padlet.com/anne_marie_harr/haematology/wish/216780710 Coursework https://padlet.com/anne_marie_harr/haematology/wish/216780842 when will student with extension get their marks? Interms of case study in the exams will it be as complicated as the coursework? can we have some examples please

Ans: Examples of the case studies have been provided and again as has been stated in sessions, will not be as involved as the coursework

]]> 2017-12-17 17:30:22 UTC https://padlet.com/anne_marie_harr/haematology/wish/216780842 Can we please have the revision slides posted https://padlet.com/anne_marie_harr/haematology/wish/216793010 2017-12-17 18:57:49 UTC https://padlet.com/anne_marie_harr/haematology/wish/216793010 Is the diagram of gene regulation to Iron is a must to learn? I am struggling to understand the process https://padlet.com/anne_marie_harr/haematology/wish/216798024 You need to understand the concepts of how iron is regulated. Whether that is by this diagram or others does not matter(there are many ways that this is explained in different sources so try another haematology book perhaps)]]> 2017-12-17 19:33:06 UTC https://padlet.com/anne_marie_harr/haematology/wish/216798024 In terms of anaemia investigation what tests are done? https://padlet.com/anne_marie_harr/haematology/wish/216918971 1) Haemocrit- looking at % of RBC 
2)FBC looking at MCV and size of RBC 
3) concentration of haemoglobin 
4) Reticulocyte Count to see the causes of anaemia wheather detruction of lack of production of RBC 
I am I in the right track?

Ans: Not quite sure exactly what you are asking here, but these are relevant tests in the investigation of anaemia yes.


]]> 2017-12-18 12:32:24 UTC https://padlet.com/anne_marie_harr/haematology/wish/216918971 How important is the treatment for the leukemia lecture? or is diagnosis the main focus of that lecture? https://padlet.com/anne_marie_harr/haematology/wish/217046493
Ans: All material is relevant, I cannot tell you what to revise or what will be on the exam]]> 2017-12-18 18:04:39 UTC https://padlet.com/anne_marie_harr/haematology/wish/217046493 Investigation of iron deficiency, what are the limitation? is iron serum not reliable because concentration of iron can be normal even in case of anaemia? https://padlet.com/anne_marie_harr/haematology/wish/217474967
Ans: Normally less than 1% of the total body iron is measureable as serum iron - therefore it gives a poor representation  of the total body stores]]> 2017-12-20 12:58:03 UTC https://padlet.com/anne_marie_harr/haematology/wish/217474967 Haematology of iron deficiency are we meant to know the normal ranges? eg normal reticulocyte count number https://padlet.com/anne_marie_harr/haematology/wish/217477471 Ans: As explained in the lectures and revision sessions, you are not expected to have learnt the reference ranges, if these are relevant to a question you will be given the appropriate values]]> 2017-12-20 13:10:32 UTC https://padlet.com/anne_marie_harr/haematology/wish/217477471 In iron deficiency anaemia what test is done to bone marrow ? is it Bone marrow aspiration and if so is this to determine the cause of anaemia https://padlet.com/anne_marie_harr/haematology/wish/217493840 Ans: It would probably be unusual to do this to diagnose iron deficiency although it is the gold standard , this will show a lack of stored iron if there is deficiency.]]> 2017-12-20 14:22:54 UTC https://padlet.com/anne_marie_harr/haematology/wish/217493840 https://padlet.com/anne_marie_harr/haematology/wish/217668678 2017-12-21 10:41:45 UTC https://padlet.com/anne_marie_harr/haematology/wish/217668678 What test can be carried to differentiate b12 deficiency from folate deficiency https://padlet.com/anne_marie_harr/haematology/wish/217851825 Ans: Simplest  are measurement of serum B12 and serum or red cell folate]]> 2017-12-22 13:35:06 UTC https://padlet.com/anne_marie_harr/haematology/wish/217851825 In haemolytic anaemia iron level is low in intravascular but high in extravascular why? is it due to loss in urine? https://padlet.com/anne_marie_harr/haematology/wish/217864542 Ans: given elsewhere on this wall]]> 2017-12-22 15:10:54 UTC https://padlet.com/anne_marie_harr/haematology/wish/217864542 do we need to know in full details different between intravascular and extravascular haemolytic anaemia https://padlet.com/anne_marie_harr/haematology/wish/217866352 Ans:Yes]]> 2017-12-22 15:23:29 UTC https://padlet.com/anne_marie_harr/haematology/wish/217866352 Blood Transfusion lecture do we need to know the process of each and their shelf life? https://padlet.com/anne_marie_harr/haematology/wish/217927175 You need to be able to give an overview at least]]> 2017-12-23 19:23:35 UTC https://padlet.com/anne_marie_harr/haematology/wish/217927175 https://padlet.com/anne_marie_harr/haematology/wish/217977662 Will you be putting up examples of good and bad written essays for
 past essay questions.]]> 2017-12-25 15:42:26 UTC https://padlet.com/anne_marie_harr/haematology/wish/217977662 In Leukaemia, there are many names of conditions do we need to know all eg cause of leukaemia if inherited should we remember all examples of condition given? https://padlet.com/anne_marie_harr/haematology/wish/217983859 Ans:  This is not really very clear, I can only reiterate that all content is relevant, including any specified reading such as leukaemia classification and (on a different topic) the SHOT report]]> 2017-12-25 19:40:46 UTC https://padlet.com/anne_marie_harr/haematology/wish/217983859 In ALL and AML are we meant to know all different name of genetic abnormalities ? Also the case study examples give at 3rd malignancy lecture could they be similar to the exam question? as they very complicated https://padlet.com/anne_marie_harr/haematology/wish/218030591 Ans: please see answers to related questions]]> 2017-12-27 02:43:00 UTC https://padlet.com/anne_marie_harr/haematology/wish/218030591 Do we need to know the names of all drugs given in ALL and how they administered https://padlet.com/anne_marie_harr/haematology/wish/218071921 Ans: we did not cover how they were administered particularly. Examples of names would be fine]]> 2017-12-27 20:04:56 UTC https://padlet.com/anne_marie_harr/haematology/wish/218071921 In Autoimmune thrombocytopenic purpura why does the increased destruction of platelets in the spleen not lead to splenomegaly? https://padlet.com/anne_marie_harr/haematology/wish/218098675 Ans:  Most literature simply tells us that there is no splenomegaly (and in fact if there is splenomegaly a different cause should be looked for). There is little explanation as to why, however, it is mainly when the spleen is overworked destroying red cells that splenomegaly is seen.]]> 2017-12-28 11:28:33 UTC https://padlet.com/anne_marie_harr/haematology/wish/218098675 Case study in coagulation lecture, could the exam have thee sorts of case studies https://padlet.com/anne_marie_harr/haematology/wish/218129979 Ans: The case study on the exam could be from any area of the haematology or clinical biochemistry]]> 2017-12-29 01:21:05 UTC https://padlet.com/anne_marie_harr/haematology/wish/218129979 What are the objectives for the transfusion lecutre? Do we need to know in detail how different products for transition are made/stored and When they are used? https://padlet.com/anne_marie_harr/haematology/wish/218180987 Ans: The key points of the lecture are the products available and what they might be used for and also the hazards associated with transfusion]]> 2017-12-30 11:10:02 UTC https://padlet.com/anne_marie_harr/haematology/wish/218180987 for the second coagulation lecture should we remember all tests and disorders or what are the key area https://padlet.com/anne_marie_harr/haematology/wish/218230654 Ans: I cannot tell you what to learn or not. All content is important.]]> 2017-12-31 19:52:59 UTC https://padlet.com/anne_marie_harr/haematology/wish/218230654 is pro-coagulation involve the primary mechanism and anti involves all factors and TF ? https://padlet.com/anne_marie_harr/haematology/wish/218231715 Ans: I do not understand this question, please rephrase]]> 2017-12-31 21:05:05 UTC https://padlet.com/anne_marie_harr/haematology/wish/218231715 https://padlet.com/anne_marie_harr/haematology/wish/218408273 For immunology could you plz post essay style question as promised in revision]]> 2018-01-02 21:54:19 UTC https://padlet.com/anne_marie_harr/haematology/wish/218408273 How do you tell from a FBC whether a patient has AML or ALL b3007239 https://padlet.com/anne_marie_harr/haematology/wish/218508921 Ans: You can't really. At the very least you would need a blood film as well.]]> 2018-01-03 14:43:18 UTC https://padlet.com/anne_marie_harr/haematology/wish/218508921 In the case study from malignancy 3, the child peter is diagnosed with ALL, but has a low WBC count. Shouldn't it be high in ALL? Why is it low? Why haven't the blast cells left the BM and flooded peripheral blood? b3007239 https://padlet.com/anne_marie_harr/haematology/wish/218511180 Ans: This is a good question. WCC can be variable in many forms of leukaemia. There does not seem to be a specific consensus on when it is high or low. Levels of functional white cells are going to be low. Sometimes blast cells are seen in the peripheral blood film so clearly they can spill over, but whether they do this may well depend on the cell type affected and the stage of differentiation it reaches (i.e. related to the specific defect causing the leukaemia)- they may never reach a stage that would signal readiness to leave the marrow but are still impeding formation of new cells.]]> 2018-01-03 14:49:17 UTC https://padlet.com/anne_marie_harr/haematology/wish/218511180 https://padlet.com/anne_marie_harr/haematology/wish/218538283 2018-01-03 15:54:08 UTC https://padlet.com/anne_marie_harr/haematology/wish/218538283 What do we need to know about leukemia classification? https://padlet.com/anne_marie_harr/haematology/wish/218540721 Ans: You need to know the WHO and FAB systems  what is the difference between them. As I have pointed out several times now, this was an area where some additional (brief) reading was essential - and is on BB]]> 2018-01-03 16:00:52 UTC https://padlet.com/anne_marie_harr/haematology/wish/218540721 is there a link between megaloblastic anaemia and acute leukaemia? thankyou https://padlet.com/anne_marie_harr/haematology/wish/218567410 Ans: Not particularly that I am aware of. Some aspects of the presentation may be  similar but I am not aware of a specific pathological link]]> 2018-01-03 17:05:48 UTC https://padlet.com/anne_marie_harr/haematology/wish/218567410 do we need to learn co-ag cascade, the picture in lecture 1 of co-ag, slide 30? https://padlet.com/anne_marie_harr/haematology/wish/218658465 IAns:  have spoken about this on several occasions in the lectures and revision session, if you were there you would know the answer to this. You will not be asked to draw this out, but you should know the key ideas and steps.]]> 2018-01-04 00:18:32 UTC https://padlet.com/anne_marie_harr/haematology/wish/218658465 Just to clarify in terms of case studies should we practice the ones in the lectures? So in malignancy and anaemia lectures https://padlet.com/anne_marie_harr/haematology/wish/218712250 Same for clinical biochemistry ]]> 2018-01-04 11:52:19 UTC https://padlet.com/anne_marie_harr/haematology/wish/218712250 This is irrelevant but myself and other colleagues have been emailing Dr Louise about pharmacology results and no answer, we aware that she's been unwell before Christmas but any idea when our results will be released? https://padlet.com/anne_marie_harr/haematology/wish/218712470 Ans: I will try and look into this for you AMH]]> 2018-01-04 11:53:46 UTC https://padlet.com/anne_marie_harr/haematology/wish/218712470 As hemolytic anaemia was heavily covered in the coursework, will it still be on the exam? https://padlet.com/anne_marie_harr/haematology/wish/218835411 Ans:  Any topic may come up in some form on the exam.]]> 2018-01-04 19:41:22 UTC https://padlet.com/anne_marie_harr/haematology/wish/218835411 In https://padlet.com/anne_marie_harr/haematology/wish/218920492 2018-01-05 11:50:34 UTC https://padlet.com/anne_marie_harr/haematology/wish/218920492 In how much detail do we need to learn CML https://padlet.com/anne_marie_harr/haematology/wish/218920517 Ans:  You should learn the module content - I cannot tell you what to revise i.e what is on the exam. ]]> 2018-01-05 11:50:48 UTC https://padlet.com/anne_marie_harr/haematology/wish/218920517 Do we need to remember the international normalise ratio equation? Or just how it is used? https://padlet.com/anne_marie_harr/haematology/wish/218927123 Ans: you need to know what it is and how it might be used]]> 2018-01-05 12:46:01 UTC https://padlet.com/anne_marie_harr/haematology/wish/218927123 For the essay questions, is it a choice of 2 out 4 or 2 out of 3? https://padlet.com/anne_marie_harr/haematology/wish/219039749 Ans: Please see the example exam]]> 2018-01-05 20:59:29 UTC https://padlet.com/anne_marie_harr/haematology/wish/219039749