The Best Protection is Early Detection by https://padlet.com/stonemm/2wl145wj7vyh8owr Breast Cancer's role in Genetics en-us 2020-10-15 14:37:30 UTC 2024-12-07 23:39:42 UTC hello@padlet.com https://padlet.net/icons/png/1f49e.png Uncontrolled cell growth originating in the breast tissue that forms a tumor that is commonly seen on x-ray, mammogram, or felt my the individual or their partner. stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883109984 2020-11-02 17:02:39 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883109984 Not all lumps felt in the breast are cancerous however, they do increase the risk of developing cancer. stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883135714 2020-11-02 17:07:43 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883135714 Outcomes vary depending on what stage the cancer is and depending if it has spread or not. stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883187212 -TNM
Stage 0-4]]> 2020-11-02 17:18:20 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883187212 American cancer society. (2020). Breast cancer. The American cancer society. Retrieved from: https://www.cancer.org/cancer/breast-cancer.html?&utm_source=google&utm_medium=cpc&utm_campaign=&utm_term=breast%20cancer&utm_content=_dc%7cpcrid%7c434766942428%7cpmt%7ce%7cpkw%7cbreast%20cancer%7cslid%7c%7cpgrid%7c97799927741%7cptaid%7ckwd-11661791%7c&gclid=CjwKCAjw5p_8BRBUEiwAPpJO69P96OsubLOCn2qd0wPVNhTvj_tEve6r5ZBHw_NKmWlOOgZ7KxKeBxoC-ZIQAvD_BwE&gclsrc=aw.ds stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883357200 2020-11-02 17:54:33 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883357200 Breast cancer organization (2020). Stages of breast cancer. Charity Navigator. Retrieved from: https://www.breastcancer.org/symptoms/diagnosis/staging stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883358900 2020-11-02 17:54:55 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883358900 Division of cancer prevention and control. (2020). Breast Cancer. Centers for disease control and prevention. Retrieved from: https://www.cdc.gov/cancer/breast/statistics/index.htm stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883360146 2020-11-02 17:55:12 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883360146 Helping women now. (2019). Breast self-exam. National breast cancer foundation. Retrieved from: https://www.nationalbreastcancer.org/breast-self-exam stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883361129 2020-11-02 17:55:25 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883361129 Mayo Clinic. (2018). Breast cancer prevention: how to reduce your risk. Healthy lifestyle women’s health. Retried from: https://www.mayoclinic.org/healthy-lifestyle/womens-health/in-depth/breast-cancer-prevention/art-20044676?p=1 stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883362189 2020-11-02 17:55:39 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883362189 Patient library of genetic support foundation. (2020). Breast cancer. Genetic support foundation. Retrieved from: https://www.geneticsupport.org/genetics-cancer/breast-cancer/ stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883363224 2020-11-02 17:55:54 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883363224 A multifactorial condition is one that there is a presence of a mutated gene, and in order for the mutation to be expressed, there also may have to be the presence of an environmental or lifestyle factor such as smoking, environmental toxins, diet, or ageing, or there has to be enough of the mutated gene to express the condition. stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883404270 2020-11-02 18:05:10 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883404270 Risk factors stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883438860 Gender
Age
Race
Family History
Reproductive/Hormonal History
Previous Breast cancer History
Dense breast tissue
Lack of physical activity 
Alcohol Consumption
Obesity of overweight
Hormone replacement therapy

]]> 2020-11-02 18:12:24 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883438860 Genetic Predisposition stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883456108 -Hereditary Breast and Ovarion Cancer syndrome (BRCA 1 + 2)
-ATM- related Breast Cancer
-Hereditary Diffuse Gastric Cancer (CDH1)
-CHEK2- related Breast Cancer
-NBM- related Breast Cancer
-Neurofibromatosis, type 1 (NF1)
-PALB2- related Breast Cancer
-PTEN Hamartoma Tumor syndrome (PTEN)/ Cowden Syndrome
-Peutz-Jeghers syndrome (STK11)
-Li-Fraumeninsyndrome (TP53)
-HER2
]]> 2020-11-02 18:16:21 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/883456108 What is the SEER database? stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884644466 Survival rates have improved markedly in the last 10 years. We now can give a percentage of likelihood that an individual will beat breast cancer depending on the stage from the SEER database. ]]> 2020-11-03 01:42:00 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884644466 Most Breast Cancer survival rates stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884651873 Localized cancer has a 99% chance of survival. 
Regional cancer has an 86% chance of survival.
Distant cancer has a 27% chance of survival.
]]> 2020-11-03 01:46:12 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884651873 Triple-negative breast cancer (TNBC) lack estrogen, progesterone and HER2 receptors. stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884661474 Localized cancer has a 91% chance of survival. 
Regional cancer has a 65% chance of survival.
Distant cancer has a 11% chance of survival. 
]]> 2020-11-03 01:51:35 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884661474 Inflammatory breast cancer (IBC) stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884671472 Localized statistics are not available because of how quickly it spreads and usually by the time you notice the inflammatory symptoms it has spread to nearby lymph. 
Regional survival rates is 52%.
Distant survival rates is 18%.
]]> 2020-11-03 01:57:11 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884671472 Detection of Breast Cancer stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884683385 Imaging Studies-
MRI (magnetic resonance imaging)
Breast Ultrasound
Mammogram
Biopsy
Self Breast Exam- watch video below to learn proper ways and time to complete SBE.
https://www.nationalbreastcancer.org/breast-self-exam ]]> 2020-11-03 02:04:51 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884683385 Stage 0 Breast Cancer treatment options stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884713653 -Breast-Conserving Surgery (BCS)
-Mastectomy with sentinel lymph node biopsy (SLNB).
-Hormone therapy]]> 2020-11-03 02:23:55 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884713653 Estrogen Receptor-Positive stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884731351 -emergence of the CDK 4/6 inhibitors for metastatic cancer. ]]> 2020-11-03 02:34:32 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884731351 Stage 1 stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884731603 -BCS- lumpectomy, partial mastectomy
-Mastectomy
-Radiation therapy
-Hormone therapy
-Chemotherapy]]> 2020-11-03 02:34:41 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884731603 Stage 2 stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884872028 -Surgery: lumpectomy, partial mastectomy, mastectomy.
-Radiation
- Chemotherapy, Hormone Therapy, HER2 Targeted drugs
-Systemic Therapy]]> 2020-11-03 04:00:33 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884872028 Stage 3 stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884898656 -Chemotherapy
-Surgery: BCS, mastectomy
-Radiation therapy]]> 2020-11-03 04:15:22 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/884898656 Who does it affect? stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/893904600 Breast cancer diagnosis rates per 100,000 women. 
-Caucasions- 125.8
-African Americans: 121.3
-Asian/Pacific Islanders: 97.7
-Hispanics: 94.5
-American Indian/Alaska Natives: 69.2]]> 2020-11-05 13:42:32 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/893904600 HER2 Treatments stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/893991440 -1 in 5 women have this enzyme on the surface of their cancer cells that promote rapid growth.
-Monoclonal Antibodies 
-Antibody-Drug Conjugate (ADC)
-Kinase Inhibitors]]> 2020-11-05 14:03:30 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/893991440 Other Treatments Available stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894002016 -Targeted Therapy
-Immunotherapy]]> 2020-11-05 14:05:58 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894002016 HER2-positive breast cancer stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894190055 -Herceptin
-Neoadjuvant therapy (therapy delivered before surgery)
-drug-antibody conjugates: ado-trastuzumab emtansine (T-DM1)]]> 2020-11-05 14:45:37 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894190055 Triple negative breast cancer (TNBC) stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894248440 -Immunotherapy
-PARP Inhibitors
-Selected Androgen Receptor modulators (SARMs)]]> 2020-11-05 14:57:18 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894248440 BCRF. (2019). breast cancer treatments: current, new and emerging therapies. Breast Cancer Research Foundation. Retrieved from: https://www.bcrf.org/blog/breast-cancer-treatments-current-new-and-emerging-therapies stonemm https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894779650 2020-11-05 16:41:49 UTC https://padlet.com/stonemm/2wl145wj7vyh8owr/wish/894779650