CASO: ADENOMEGALIAS Y ESPLENOMEGALIAS by DAYANA GUALLI

CASO: ADENOMEGALIAS Y ESPLENOMEGALIAS by DAYANA GUALLI https://padlet.com/guallidayana/2ui7o95e4pi2oq8e APOYO DE FARMACOLOGÍA en-us 2020-05-27 22:44:54 UTC 2023-02-18 02:36:46 UTC hello@padlet.com LINFOMA HODKING DE CÉLULAS B (R-CHOP) guallidayana https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/645581662 2020-07-02 03:37:09 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/645581662 Caso Clinico castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667197754 28 años
Alérgica a la penicilina]]> 2021-08-03 00:29:06 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667197754 Diagnostico castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667198154 2021-08-03 00:29:32 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667198154 Antecedentes castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667203406 2021-08-03 00:35:34 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667203406 Familiares castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667203620 Cáncer de mama]]> 2021-08-03 00:35:49 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667203620 Personales castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667212550

Higroma Quístico

Hipermenorrea

]]> 2021-08-03 00:41:43 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667212550 Clínica castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667214129 Hipermenorrea /Astenia /Perdida de cabello /Prurito generalizado /Lesiones eritematosas en extremidades inf./ Perdida de peso 10 kg (aprox: 4 meses) ]]> 2021-08-03 00:43:15 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667214129 Examen Físico castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667218128 T°: 37,2ª C
FC: 130 lpm
FR: 30rpm - T/A:140/80mmhg
Sat: 94%
IMC:19,09
Ligera palidez de piel
Ortopnea
Ganglio de 2cm región cervical izq.
Diaforesis
Crepitantes húmedos . ]]> 2021-08-03 00:47:30 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667218128 Exámenes Complementarios castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667224379 BIOMETRIA
Hb 10,4 g/dl
Hto 32,7%,
VCM 73,3 fl
HCM 23,4 pg
9.690 leucocitos × 106/dl (59,2% neut 33,6% linf, 6,1% mono, 1,1% otros)
335.000 plaquetas × 106/dl
Hierro sérico 15 μg/dl
Ferritina 14,2 pg/l]]> 2021-08-03 00:55:04 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667224379 Imagen castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667242716 2021-08-03 01:17:10 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667242716 Rx AP y lateral castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667243145 2021-08-03 01:17:43 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667243145 TC de torax castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667247651 2021-08-03 01:22:24 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667247651 Pericardiocentesis, punción aspiración guiada por TC y biopsia por toracoscopia castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667248642 2021-08-03 01:23:28 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1667248642 Tratamiento Farmacológico davidvegamd https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668123311 2021-08-03 19:26:02 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668123311 Vincristina davidvegamd https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668124080 2021-08-03 19:27:29 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668124080 Presentación davidvegamd https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668125612 L01CA02
Liquido parenteral 1mg/ml
Solido parenteral 1 mg]]> 2021-08-03 19:30:02 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668125612 Dosis davidvegamd https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668127587 IV dosis usual 1,4 mg/m² (máx 2 mg)/sem.
En monoterapia intervalos de una semana.
Precaución extrema en el cálculo y administración.
I.H. o con un valor directo de bilirrubina en suero por encima de 3 mg/100 ml dosis a la mitad.
Vida media 23 a 85 horas]]> 2021-08-03 19:32:33 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668127587 Interacciones davidvegamd https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668130437 - Metotrexato
- Bleomicina.
- L-asparaginasa
- Fármacos que inhiben sistema P450 o CYP3A4
- Fármacos uricosúricos.
- Antiepilépticos]]> 2021-08-03 19:37:33 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668130437 Contraindicaciones davidvegamd https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668132714 Hipersensibilidad a vincristina, trastornos neuromusculares, trastorno grave de la función hepática.]]> 2021-08-03 19:41:44 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668132714 Efectos adversos davidvegamd https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668134880 Perdida sensorial, parestesias, dificultad para caminar, marcha atáxica, arreflexia tendinosa profunda atrofia muscular.]]> 2021-08-03 19:45:51 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668134880 castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668445064 • Cáncer del sistema linfático]]> 2021-08-04 03:10:56 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668445064 castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668446538 Más frecuente en personas de 20 a 40 años y en los mayores de 55 años de edad]]> 2021-08-04 03:12:27 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668446538 castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668448599 Transformación clonal de células de origen de células B]]> 2021-08-04 03:14:27 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668448599 castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668449979 Células de Reed-Sternberg binucleadas patognómicas]]> 2021-08-04 03:15:48 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668449979 Signos y síntomas castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668451479 2021-08-04 03:17:18 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668451479 castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668451898 2021-08-04 03:17:45 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668451898 Bibliografia castillo_ordonez_leonardo https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668922733

Ministerio de Salud Pública. (2014). Cuadro Nacional de Medicamentos Básicos y Registro Terapéutico (9th ed.).

Ansell S. M. (2015). Hodgkin Lymphoma: Diagnosis and Treatment. Mayo Clinic proceedings, 90(11), 1574–1583. https://doi.org/10.1016/j.mayocp.2015.07.005

R-CHOP | Cancer information | Cancer Research UK. (2019, 20 mayo). CANCER RESEARCH UK. https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/r-chop

Shanbhag, S., & Ambinder, R. F. (2018). Hodgkin lymphoma: A review and update on recent progress. CA: a cancer journal for clinicians, 68(2), 116–132. https://doi.org/10.3322/caac.21438

Ansell S. M. (2020). Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management. American journal of hematology, 95(8), 978–989. https://doi.org/10.1002/ajh.25856

LaCasce A. S. (2019). Treating Hodgkin lymphoma in the new millennium: Relapsed and refractory disease. Hematological oncology, 37 Suppl 1, 87–91. https://doi.org/10.1002/hon.2589

]]> 2021-08-04 13:51:21 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1668922733 RITUXIMAB https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669084793 2021-08-04 16:26:15 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669084793 CICLOFOSFAMIDA https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669085248 2021-08-04 16:26:42 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669085248 PRESENTACIÓN https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669086629 100 mg concentrado para solución para perfusión

500 mg concentrado para solución para perfusión

]]> 2021-08-04 16:28:17 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669086629 DOSIS https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669086739 es de 375 mg/m2 de superficie corporal por ciclo, hasta 8 ciclos.]]> 2021-08-04 16:28:24 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669086739 FARMACODINAMIA https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669089456 Administracion IV

Vidamedia y eliminación 20 - 22 días

]]> 2021-08-04 16:31:11 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669089456 MECANISMO DE ACCIÓN https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669090973 2021-08-04 16:32:47 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669090973 EFECTOS ADVERSOS https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669103983 2021-08-04 16:46:44 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669103983 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669104223 2021-08-04 16:47:01 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669104223 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669104839 2021-08-04 16:47:42 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669104839 CONTRAINDICACIONES https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669109453 2021-08-04 16:52:27 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669109453 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669112930 2021-08-04 16:56:43 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669112930 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669113264 2021-08-04 16:57:11 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669113264 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669113777 2021-08-04 16:57:47 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669113777 PRESENTACIÓN https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669119594 500 mg polvo para solución inyectable y para perfusión.

1.000 mg polvo para solución inyectable y para perfusión EFG

2.000 mg polvo para solución inyectable y para perfusión

]]> 2021-08-04 17:04:19 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669119594 MECANISMO DE ACCIÓN https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669120622 2021-08-04 17:05:10 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669120622 FARMACODINAMIA https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669124013 ADD oral de hasta 100 mg,
biodisponibilidad del 75%.
Se distribuyen por todos los tejidos
Eliminación por la orina]]> 2021-08-04 17:09:01 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669124013 DOSIS https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669126287

dosis de 300 mg/m2 i.v. los días 1 y 8;

600 mg/m2 el día 1

650 mg/m2 i.v. los días 1 y 8

]]> 2021-08-04 17:11:27 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669126287 CONTRAINDICACIONES https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669127263 2021-08-04 17:12:36 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669127263 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669127929 2021-08-04 17:13:29 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669127929 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669128616 2021-08-04 17:14:23 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669128616 INTERACCIONES https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669129790 Se podría producir un incremento de la concentración de metabolitos citotóxicos con:

- Alopurinol, Azatioprina, Hidrato de cloral.

]]> 2021-08-04 17:15:56 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669129790 EFECTOS SECUNDARIOS https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669130617 2021-08-04 17:17:02 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669130617 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669131149 2021-08-04 17:17:45 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669131149 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669131291 2021-08-04 17:17:56 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669131291 Tratamiento no Farmacológico guallidayana https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669275987 2021-08-04 20:41:33 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669275987 Sistema de apoyo guallidayana https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669304180 2021-08-04 21:40:48 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669304180 Metas razonables guallidayana https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669305302 2021-08-04 21:43:02 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669305302 Tiempo para si mismo guallidayana https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669306006 2021-08-04 21:44:10 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669306006 Actividad física guallidayana https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669306789 2021-08-04 21:45:47 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669306789 Trasplante de medula ósea guallidayana https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669307273 2021-08-04 21:46:50 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669307273 Clorhidrato de Doxorrubicina R-CHOP zapatasilvana97 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669424515 2021-08-05 01:00:27 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669424515 Mecanismo de acción zapatasilvana97 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669427277 2021-08-05 01:03:42 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669427277 Farmacodinamia zapatasilvana97 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669428424 La semivida distributiva es de 5 minutos, lo que sugiere que los tejidos absorben rápidamente la doxorrubicina. Vida media terminal = 20 - 48 horas, su principal metabolito, el doxorrubicinol, se unen en un 74-76% a las proteínas plasmáticas. El grado de unión es independiente de la concentración plasmática hasta 1,1 mcg / ml. No atraviesa la barrera hematoencefálica

]]> 2021-08-05 01:05:04 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669428424 Reacciones adversas zapatasilvana97 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669429662 Fiebre neutropénica, infección; neutropenia, trombocitopenia, anemia, leucopenia, linfocitopenia, pancitopenia; anorexia, deshidratación, hipopotasemia; insomnio; arritmia, cardiomiopatía]]> 2021-08-05 01:06:32 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669429662 Contraindicaciones zapatasilvana97 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669430903 Hipersensibilidad a doxorubicina, mieloinhibición inducida por quimioterapia y radioterapia, cardiopatía grave.]]> 2021-08-05 01:08:01 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669430903 Interacciones zapatasilvana97 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669432393 Potencia toxicidad de: otros antineoplásicos.]]> 2021-08-05 01:09:39 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669432393 Dosificación zapatasilvana97 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669434447 Para el tratamiento del linfoma no Hodgkin (LNH): por vía intravenosa de dosis: Adultos y niños: 40 a 50 mg / m2 / dosis IV una vez IV mensual o 25 mg / m2 / dosis en los días 1 y 8 de cada mes.]]> 2021-08-05 01:12:03 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669434447 PREDNISOLONA https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669475024 2021-08-05 01:56:45 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669475024 PRESENTACIÓN https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669530925 Solido oral de 5 20 y 50 mg ]]> 2021-08-05 02:52:55 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669530925 FARMACODINAMIA https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669532548 Concentraciones plasmáticas máximas en aprox. 1-2hrs
La biodisponibilidad en plasma es de aprox. 70-80%.
Su vida media de eliminación es de 2.5 a 3.5 h]]> 2021-08-05 02:54:24 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669532548 DOSIS https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669535568 100 mg/ día. Repetir cada 3 semanas por 6 ciclos ]]> 2021-08-05 02:57:20 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669535568 EFECTOS SECUNDARIOS https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669544080

dolor de cabeza, náuseas, cambios extremos de humor, incluso felicidad inusual, cambios de personalidad. dificultad para conciliar el sueño o para mantenerse dormido, piel delgada, frágil

]]> 2021-08-05 03:05:58 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669544080 CONTRAINDICACIONES https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669544742 Hipersensibilidad a la prednisolona o a otros glucocorticoides; enf. víricas agudas (p.ej. varicela, herpes simple o herpes zoster); tuberculosis latente

]]> 2021-08-05 03:06:43 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669544742 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669550000 2021-08-05 03:11:37 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669550000 INTERACCIONES https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669551332 La administración simultánea con fenobarbital, fenitoína, efedrina disminuye el efecto terapéutico ]]> 2021-08-05 03:12:53 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669551332 https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669551888 2021-08-05 03:13:19 UTC https://padlet.com/guallidayana/2ui7o95e4pi2oq8e/wish/1669551888