Moyamoya Disease by https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2 By Samira Steger, Vinzenz Fraiß en-us 2021-03-24 18:24:20 UTC 2026-04-17 06:39:42 UTC hello@padlet.com What is Moyamoya disease? 8ny8j4g2wb https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349505244 * Certain arteries in the brain are constricted
*The blood flow is blocked by constriction and blood clots (=thrombosis)
*To compensate for the blockage collateral vessels are built for circulation
*Collateral vessels are weak and easily cause bleeding, aneurysm and thrombosis
*Results in hemorrhagic stroke or seizure]]> 2021-03-24 18:26:26 UTC https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349505244 Where does the name come from? 8ny8j4g2wb https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349528788 *In MR angiography collateral vessels look like a "puff of smoke", similar to a cloud, which means "moyamoya" in Japanese
*Cerebral angiography is the standard method to diagnose and follow the progression of the disease


]]> 2021-03-24 18:31:00 UTC https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349528788 Pathophysiology 8ny8j4g2wb https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349560090 *Blood leaks out of the arteries, which causes pressure on the brain, leading to headaches and progressing to cognitive disabilities
*10% of the cases are familial
*Different variations of Moyamoya disease are caused by genetic mutations on different chromosomes and genes
*The pathogenesis is so far unknown, although RNF213 has been implicated]]> 2021-03-24 18:37:25 UTC https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349560090 Austrian involvement 8ny8j4g2wb https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349601268 *In 2020 the IMP (Research Institute Of Molecular Pathology located at the Vienna Biocenter) published their breakthrough on the pathogenesis of the Moyamoya disease
*"Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and  distinct ubiquitin-transfer mechanism"
(https://pubmed.ncbi.nlm.nih.gov/32573437/)]]> 2021-03-24 18:45:55 UTC https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349601268 Refrences 8ny8j4g2wb https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349673848
  • https://pubmed.ncbi.nlm.nih.gov/32573437/ by
    Ahel, J., Lehner, A., Vogel, A., Schleiffer, A., Meinhart, A., Haselbach, D., Clausen, T. (2020) 
  • https://www.bcm.edu/healthcare/specialties/neurosurgery/cerebrovascular-and-stroke-surgery/moyamoya-disease
  • https://en.wikipedia.org/wiki/Moyamoya_disease
  • https://www.mayoclinic.org/diseases-conditions/moyamoya-disease/symptoms-causes/syc-20355586


    • ]]>     2021-03-24 19:01:49 UTC https://padlet.com/8ny8j4g2wb/2pm19i2ts0ao49w2/wish/1349673848