Synthetic Chemistry including Combinatorial Methods by JANNATUL FERDOUS https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8 en-us 2021-04-25 14:20:36 UTC 2023-02-19 07:20:23 UTC hello@padlet.com https://padlet.net/icons/png/1f469-1f52c.png Synthetic chemistry: IbnaHasanShawn https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457817779
  • Connection between structure and reactivity
  • Way to build organic compounds from smaller entities 
  • Have enables the discovery of many breakthrough therapies.
    • ]]>     2021-04-26 04:37:51 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457817779     IbnaHasanShawn https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457862001  Goal of Synthetic Chemistry
    • Enhance structural diversity
    • Developing a probe
    • Developing lead molecule
    • Enhance understanding of biological targets
    ]]>     2021-04-26 04:56:20 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457862001     Examples of synthetic chemistry IbnaHasanShawn https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457864326 2021-04-26 04:57:29 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457864326 Methods are used in Synthetic chemistry IbnaHasanShawn https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457865936
  • Asymmetric hydrogenetion
  • Asymmetric epoxidation
  • Combinatorial method
  • Pd-catalyzed cross couplings

    • ]]>     2021-04-26 04:58:17 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457865936     Combinatorial methods IbnaHasanShawn https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457869328 Principle: 
    • Prepare a large number of different compounds.
    • Identify the most promising compound.

    ]]>     2021-04-26 04:59:59 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457869328     Two phases of combinatorial methods IbnaHasanShawn https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457871275 1.   Making a library.
    • collection of the finally synthesized compounds.
    ]]>     2021-04-26 05:01:01 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457871275     Two phases of combinatorial methods IbnaHasanShawn https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457878089 2.  Finding the active compound.
    •  Screening mixtures for biological activity



    ]]>     2021-04-26 05:04:15 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1457878089     jannatulferdous13 https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463887161 Types of combinatorial synthesis

    1)Solid phase combinatorial chemistry.
    •  starting compound is attached to an insoluble resin bead. 
    • Reagents are added to the solution in excess.
    • products can be isolated by simple filtration. 
    ]]>     2021-04-27 12:09:15 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463887161     Examples jannatulferdous13 https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463887870 Merrifield resin ]]> 2021-04-27 12:09:29 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463887870 Examples jannatulferdous13 https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463890002 Rink amide resin ]]> 2021-04-27 12:10:10 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463890002 jannatulferdous13 https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463890713 Types of combinatorial synthesis

    2)Solution phase combinatorial chemistry: 
    • Conducting chemical reaction simultaneously.
    •  Most ordinary synthetic chemistry takes place in solution phase.
    In solution phase used 2 vehicles-
    • PEG
    • Liquid Teflon
    ]]>     2021-04-27 12:10:23 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463890713     Synthetic methods used in Combinatorial Chemistry jannatulferdous13 https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463891566 1. Split and mix synthesis or Split and pool synthesis or Portioning – Mixing synthesis:
    • Starting material is split in ‘n’ portions, reacted with ‘n’ building blocks.
    • Recombined in one flask.
    • This procedure is repeated.

    ]]>     2021-04-27 12:10:39 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463891566     Synthetic methods used in Combinatorial Chemistry jannatulferdous13 https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463892378 2. Parallel synthesis:
    • Each starting material is reacted with each building block separately.
    •  The product is split into ‘n’ portions before it is reacted with n new building blocks.
    ]]>     2021-04-27 12:10:54 UTC https://padlet.com/jannatulferdous13/2b6xs8job6qalsd8/wish/1463892378