Questions for the B cell clinic by Fear, David

2023-11-16 00:24:56 UTC

If B cells are unable to undergo somatic hypermutation, how might this affect the effectiveness of the adaptive immune response? Consider both the primary and secondary immune responses.

2023-11-16 00:26:50 UTC

Why do you think the immune system employs processes like somatic hypermutation in B cells? What advantages does it confer in terms of survival and adaptation?

2023-11-16 00:28:06 UTC

How does the immune system balance the need for B cell diversity with the risk of generating self-reactive antibodies? What mechanisms are in place to prevent the activation of self-reactive B cells?

2023-11-16 00:29:04 UTC

What factors contribute to the formation and longevity of memory B cells? How does the presence of memory B cells influence the speed and strength of the secondary immune response?

relevant papers

davidfear2 — 2023-11-16 10:49:56 UTC

Potential roles of Activation-Induced cytidine Deaminase in promotion or prevention of autoimmunity in humans.

A.Durandy, T. Cantaert, S. Kracker and E.Meffre

Autoimmunity. 2013 Mar; 46(2): 148–156.

DOI: 10.3109/08916934.2012.750299

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

P.Revy et al

Cell. 2000 Sep 1;102(5):565-75.

DOI: 10.1016/s0092-8674(00)00079-9