2. Is there a need to change the current research paradigm? If not, why not? If yes, what and how? by Rafael Frias

2. Is there a need to change the current research paradigm? If not, why not? If yes, what and how? by Rafael Frias https://padlet.com/rafribe/1pw8qir5pebrtti1 en-us 2020-05-05 08:40:57 UTC 2021-09-09 09:48:40 UTC hello@padlet.com shifting towards non animal experiments if its possible https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727589778 2021-09-09 09:43:20 UTC https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727589778 Yes change is needed - not everything can be studied in humans so animal models will be needed; alternative methods are also needed (e.g. organoids) BUT also a better research needs to be done prior to the experiments https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727592721 2021-09-09 09:45:18 UTC https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727592721 Tissue engineering maybe https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727593576 2021-09-09 09:45:57 UTC https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727593576 avoiding bias when doing a SR - is it objective when my colleague is double checking my systematic search https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727594955 2021-09-09 09:46:56 UTC https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727594955 Yes we agree there is need to chnage current paradigm, and indeed we are already moving in this direction by developing new techniques addressing 3R. Such as using organoids, using chip+based systems, computer simulations for drug-drug., protein-protein interactions, etc. https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727596010 2021-09-09 09:47:44 UTC https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727596010 what is the paradigm? I think it can vary between different groups how they work https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727596332 2021-09-09 09:47:59 UTC https://padlet.com/rafribe/1pw8qir5pebrtti1/wish/1727596332