Zofran (Ondansetron) by https://padlet.com/aholiway56/1hk68gu0yzrddg6w Made by Antonia Holiway & Matt Johnston en-us 2022-05-22 00:13:17 UTC 2022-06-10 14:57:17 UTC hello@padlet.com Mechanism of Action aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207395 Blocks serotonin receptors on the peripheral vagus nerve terminal and centrally in the chemoreceptor trigger zone (CTZ).]]> 2022-05-22 00:19:28 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207395 Indication Therapeutic Uses aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207672 -Acute Nausea / Vomting
- Nausea / Vomiting caused by Gastritis
- Nausea / Vomiting caused by Morning Sickness
- Given Prophylactic to prevent Nausea / Vomiting from Radiotherapy and Anesthesia
 
 ]]> 2022-05-22 00:19:35 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207672 Adverse Effects aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207704 - Headache
- Diarrhea
- Dizziness
-Q-T interval prolongation
May occur due to hERG K+ channel blockage which suppresses autonomic reflexes that contribute to bradycardia, hypotension, and tachyarrhythmias
- Serotonin Syndrome
Ondansetron is a 5-HT3 receptor antagonist. It binds to the receptor instead of serotonin which causes in increase in free serotonin. When combined with other serotonergic drugs like SSRI's, it can cause serotonin syndrome.
- Constipation
Likely due to the blockade of 5-HT3 gut receptors which result in decreased gut motility. ]]> 2022-05-22 00:19:42 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207704 Nursing Considerations aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207740 -Close monitoring of ECG (if applicable)for prolonged QT
-Monitor serum K+ and Mg 
- Monitor for decreased bowel sounds
-Asses for signs and symptoms of serotonin syndrome or signs of hypersensitivity

 ]]> 2022-05-22 00:19:50 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207740 NCLEX question aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207818 Q: If a patient is prescribed Zofran IV, what other medication might the nurse question on the MAR?

A: Sotalol 
B: Metoprolol 
C: Baclofen 
D: Prometidine]]> 2022-05-22 00:20:11 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194207818 References aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194208200 Burchum, J. R., Rosenthal, L. D., & Lehne, R. A. (2019). Lehne's pharmacology for nursing care. Elsevier/Saunders. 

EBSCO Industries. (n.d.). Ondansetron. Dynamed.com. 
Retrieved June 6, 2022, from https://www.dynamed.com/ 

Wolters Kluwer. (n.d.). Ondansetron. LexiComp. Retrieved June 6, 2022, from https://online-lexi-com.proxygw.wrlc.org/ 
]]> 2022-05-22 00:21:44 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2194208200 Pharmacokinetics aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2211090733
Distribution: transported mostly via protein binding 

Metabolism: mostly but liver (CYP3A4, CYP1A2, and CYP2D6)

Excretion: primarily through the renal system, however approx. 5% remains unmetabolized.]]> 2022-06-04 21:55:53 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2211090733 aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2212968867 Generic: Ondansetron

Brand Name: Zofran

Class: Anti-Emetic, Serotonin Receptor (5-HT3) Antagonist  ]]> 2022-06-07 02:55:39 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2212968867 Dosing aholiway56 https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2215328602 Oral, IV, IM
4mg-8mg every 8-12hours]]> 2022-06-08 18:23:54 UTC https://padlet.com/aholiway56/1hk68gu0yzrddg6w/wish/2215328602