Signs and symptoms:
Overdose: Diarrhea, increased sweating, loss of appetite, nausea or vomiting, stomach cramps or pain, swelling, pain, or tenderness in the upper abdomen or stomach area

Rare: tarry stools, bloody or cloudy urine, skin rashes
Drug to drug interactions:
-The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect. Anticoagulant dosage may require reduction if paracetamol and anticoagulants are taken for a prolonged period of time.
-Paracetamol absorption is increased by substances hat increase gastric emptying, e.g. metoclopramide.
-Paracetamol may increase chloramphenicol concentrations.
-The risk of paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes such as alcohol and anticonvulsant agents 
-Paracetamol excretion may be affected and plasma concentrations altered when given with probenecid. -Colestyramine reduces the absorption of paracetamol if given within 1 hour of paracetamol.
How to prevent, assess or manage risks/nursing considerations:
- Monitor vital signs
- cease administration if adverse effects occur, and inform medical team/senior staff
- Ask patient if they have had hx of adverse effects with paracetamol or are hypersensitive to paracetamol.
- Take note of any known allergies
(Take with water or other fluid. Can be taken with or without food)
- Should not be used with other paracetamol-containing products.
- Minimum dosing interval: 6 hours. Maximum daily dose: 4000 mg
Tamoxifen:
MOA:
Risks t