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The spill happened in the Gulf of Mexico in 2010. The blowout and oil spill on the Deepwater Horizon in the Gulf of Mexico was caused by a flawed well plan that did not include enough cement between the 7-inch production casing and the 9 7/8-inch protection casing. The oil harmed many organisms including plankton, invertebrates, fish, birds, and sea mammals, causing a wide array of adverse effects such as reduced growth, impaired reproduction, impaired physiological health, and mortality. The oil exposure is harmful to oil clean up crews. 1.8 million gallons of chemical dispersants were dumped into the Gulf. Wildlife still has not recovered from the spill. Humans are still trying to find ways to help completely remove the oil. Bacteria has been a very helpful agent in cleaning up the oil as well. The spill is a result of point source pollution.

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The tanker Exxon Valdez grounded on Bligh Reef in Alaska's Prince William Sound, rupturing its hull and spilling nearly 11 million gallons of Prudhoe Bay crude oil into a remote, scenic, and biologically productive body of water. The spill was a point source pollution spill. The Exxon Valdez spilt 42 million liters of crude oil and contaminated 1,990 kilometers of shoreline. Exposure to this oil, in turn, caused additional animal deaths. After 29 years, oil is still in the waters and shoreline from the spill. The oil harms oil clean up crew members. Several methods are being used to try and clean up the spill.

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The Camp Lejeune water contamination problem occurred at Marine Corps Base Camp Lejeune from 1953 to 1987. From the 1950s through the 1980s, people living or working at the U.S. Marine Corps Base Camp Lejeune, North Carolina, were potentially exposed to drinking water contaminated with industrial solvents, benzene, and other chemicals. The contamination of the water is a result of non-point source pollution. In February 2014, the Centers for Disease Control and Prevention found that the contaminated water at Lejeune significantly increased the risk of multiple diseases including liver cancer, kidney cancer and ALS.

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The 2015 Gold King Mine waste water spill was an environmental disaster that began at the Gold King Mine near Silverton, Colorado, when Environmental Protection Agency personnel, along with workers for Environmental Restoration LLC, caused the release of toxic waste water into the Animas River watershed. They caused the accident while attempting to drain ponded water near the entrance of the mine on August 5. The spill is a result of point source pollution. After spilling three million US gallons of mine waste water and tailings, including heavy metals such as cadmium and lead, and other toxic elements, such as arsenic, beryllium, zinc, iron and copper into Cement Creek, a tributary of the Animas River in Colorado. Residents with wells in floodplains were told to have their water tested before drinking it or bathing in it. People were told to avoid contact with the river, including by their pets, and to prevent farmed animals from drinking the water. They were advised not to catch fish in the river. The long-term impacts of the spill are unknown, as sedimentation is expected to dilute the pollutants as the spill cloud moves downstream.

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Love Canal, located near Niagara Falls in upstate New York, was a nice little working-class enclave with hundreds of houses and a school. It just happened to sit atop 21,000 tons of toxic industrial waste that had been buried underground in the 1940s and '50s by a local company. The event is a non-point source pollution. The canal families didn't know that they were being exposed to poisonous chemicals, nor were they aware that chemical wastes were being dumped in our rivers, soil, and air. Love Canal awoke a community to the unpleasantness and unfortunate realization of how toxic wastes affect out lives, and destroy our environment.

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From 1952 to 1966, the Pacific Gas and Electric Company (PG&E) dumped approximately 370 million gallons of chromium-tainted wastewater into unlined wastewater spreading ponds around the town of Hinkley, California. This is a result of non-point source pollution. Local residents experienced several symptoms associated with chromium-6 contamination including prostate, cervical, breast and stomach cancers and respiratory problems. In 1987, PG&E officials informed the state of California of high levels on chromium-6 in underground water north of the discharge ponds.

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An oil slick on the Cuyahoga River - polluted from decades of industrial waste - caught fire on a Sunday morning in June 1969 near the Republic Steel mill, causing about $100,000 worth of damage to two railroad bridges. This is an example of non-point source pollution. The fire was determined to have reached heights of over five stories and lasted between twenty and thirty minutes.  There was reported to be around $50,000 of damages including: $45,000 from the destruction of the bridge owned by Norfolk & Western Railway Co. and $5,000 from the Newburgh & South Shore Railway trestle. The most potent blaze occurred in 1952 which caused over $1.3 million in damages however, the most fatal fire happened in 1912 with a documented five deaths.  The 1969 fire, which did not incur maximum damages or fatally wound any citizen, was the most covered incident occuring on the river.  Inspired by the 1969 river fire, Congress was determined to resolve the issue of land pollution, not just in Cleveland, but throughout the United States.  The legislature passed the National Environment Policy Act (NEPA) which was signed into law on January 1, 1970.  This act helped establish the Environmental Protection Agency (EPA) which would be given the duties to manage environmental risks and regulate various sanitary-specific policies.

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Toxic wastes dumped by two factories in the 1960s and '70s contaminated the water supply and caused five leukemia deaths, three nonfatal cases of the disease and several other serious illnesses here. This is an example of point source pollution. Nearly 30 years after that landmark court case, the wells that supplied both toxic drinking water and a legacy of cancer to Woburn remain contaminated despite a $21 million cleanup effort. And no one, not even the U.S. Environmental Protection Agency which monitors the site as part of the federal Superfund program, knows whether humans are still being exposed to its witch's brew of chemicals, federal records show.

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The Elk River chemical spill occurred on January 9, 2014 when crude 4-methylcyclohexanemethanol (MCHM) was released from a Freedom Industries facility into the Elk River, a tributary of the Kanawha River, in Charleston in the U.S. state of West Virginia.Following the spill, up to 300,000 residents within nine counties in the Charleston, West Virginia metropolitan area were without access to potable water. The first estimate was that 5,000 gallons of MCHM had spilled into the river. Later, that figure was increased to 7,500 gallons. Officials said little is known about the colorless, oil-like chemical or its possible effect on human health. It is not classified as “hazardous” by regulatory authorities but little research has been done. Freedom Industries later notified the DEP that a second chemical, PPH or polyclycol ethers, had been in the leaking tank with the MCHM.  This is an example of point source pollution.

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The 1993 Milwaukee Cryptosporidiosis outbreak was a significant distribution of the Cryptosporidium protozoan in Milwaukee, Wisconsin, and the largest waterborne disease outbreak in documented United States history. The Howard Avenue Water Purification Plant (see Town of Lake water tower) was contaminated, and treated water showed turbidity levels well above normal. It was one of two water treatment plants for Milwaukee. The root cause of epidemic was never officially identified; initially it was suspected to be caused by the cattle genotype due to runoff from pastures. Over the span of approximately two weeks, 403,000 of an estimated 1.61 million residents in the Milwaukee area (of which 880,000 were served by the malfunctioning treatment plant) became ill with the stomach cramps, fever, diarrhea and dehydration caused by the pathogen. Deaths have been attributed to this outbreak, mostly among the elderly and immunocompromised people, such as AIDS patients.

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The pollutants present in the drinking water sources near Duke Energy's leaking coal ash sites exceed state health protection standards and are associated with coal and coal ash waste. Duke Energy's unlined coal ash ponds have been in place for decades near our waterways and drinking water sources. This is an example of point source pollution. Arsenic is one of the most common, and most dangerous, pollutants from coal ash. The EPA also found that living near ash ponds increases the risk of damage from cadmium, lead, and other toxic metals. Coal ash is also enriched in leachable contaminants such as arsenic and selenium that can be harmful to ecosystems near coal ash disposal sites.

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Heavy rains and melting snows washed massive amounts of nutrients—particularly nitrogen and phosphorus—from lawns, sewage treatment plants, farm land and other sources along the Mississippi River into the Gulf of Mexico. Once in the Gulf, these nutrients, which are required for plant and crop growth, trigger algae blooms that choke off oxygen in water and make it difficult, if not impossible, for marine life to survive. This is an example of non-point source pollution. The National Oceanic and Atmospheric Administration, or NOAA, estimates that the dead zone costs U.S. seafood and tourism industries $82 million a year. The impact could be devastating to the Gulf's seafood industry, which accounts for more than 40 percent of the nation's seafood. Louisiana is second in seafood production only to Alaska. The Conservancy is working with farmers to promote more effective and efficient use of fertilizers. The reconnection of rivers to their floodplains not only helps to mitigate floods, but filter excess nutrients from the water. Legislation like the RESTORE Act and Farm Bill plays critical role in protecting the country's natural resources.

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Between 1947 and 1977, General Electric (GE) dumped an estimated 1.3 million pounds of polychlorinated biphenyls (PCBs) into the Hudson River. The source of the PCB discharges was two GE capacitor manufacturing plants located in Fort Edward and Hudson Falls, New York, about 50 miles north of Albany. This is an example of point source pollution. Even today the Hudson River remains contaminated with PCBs: new report. The Hudson River remains contaminated with levels of PCBs that don't meet state and federal regulations and the river cleanup remains incomplete. The Hudson River looks clean and is teeming with fish. But, the fish and the river bottom on which they depend for food and shelter are contaminated by PCBs. PCBs probably cause cancer and can cause other serious health problems. The PCBs are not safely buried in the sediment.