# data[].attributes.headline
How is the penetrance of cancer susceptibility genes affected by the additional genetic variants, environmental factors, genetic ancestry,social economic status, even personality?

# data[].attributes.subject
How is the penetrance of cancer susceptibility genes affected by the additional genetic variants, environmental factors, genetic ancestry,social economic status, even personality?

# data[].attributes.headline
Early detection and diagnosis are very important in improving the survival rate of cancer patients.

# data[].attributes.subject
Early detection and diagnosis are very important in improving the survival rate of cancer patients.

# data[].attributes.body
Can cell free DNA, circulating tumor cells, autoantibodies and other novel tests that are obtained from blood or other minimally invasive tissue collections be used to effectively screen and identify cancers at an earlier stage? And can that lead to improvement in outcomes?

# data[].attributes.headline
It is likely that the environment impacts patients' health outcomes through epigenetic changes. Can we identify environmental effects on patients’ immune system by epigenetic profiling? Can Immune profiling of epigenetic changes identify disparities in the immune environment that may be a contributing factor in cancer incidence and outcome?

# data[].attributes.subject
It is likely that the environment impacts patients' health outcomes through epigenetic changes. Can we identify environmental effects on patients’ immune system by epigenetic profiling? Can Immune profiling of epigenetic changes identify disparities in the immune environment that may be a contributing factor in cancer incidence and outcome?

# data[].attributes.body
How does an individuals micro/macro environmental factors (zip code, air quality, water quality, food desert, proximity to factories, pesticides, etc.)  impact their cancer risk through epigenetic factors (eg. abnormal DNA repair, modifications to oncogenes, and or tumor suppressor genes)? Could this provide insight on which factors contribute to a patient's outcome, mortality and may pave the way for legislative changes to protect vulnerable communities at greater risk?

# data[].attributes.headline
Can we predict which tumors will respond to immunotherapy more effectively? Can we leverage information from the tumor immune microenvironment using clinical biopsies and FFPE specimens and blood based biomarkers to understand which tumors will respond? Particularly in cancer types where response is fairly minimal now? 

# data[].attributes.subject
Can we predict which tumors will respond to immunotherapy more effectively? Can we leverage information from the tumor immune microenvironment using clinical biopsies and FFPE specimens and blood based biomarkers to understand which tumors will respond? Particularly in cancer types where response is fairly minimal now? 

# data[].attributes.body
Can Immune profiling of Tumor microenvironment or peripheral blood uncover underlying mechanisms or biomarkers, such as such as CD8+ T cells, T cell diversity, gene signatures, and other novel biomarkers, of an individual's immune response? If so, can the immune profile be leveraged to predict immune response / IrAEs  to immunotherapy, and or create precision Immunotherapeutics/ individualized treatment regime for the treatment of cancer in a clinical setting?

# data[].attributes.headline
Can AI and machine learning be leveraged to more quickly and efficiently identify rare novel cancer causing SNPs in the human genome? 

# data[].attributes.subject
Can AI and machine learning be leveraged to more quickly and efficiently identify rare novel cancer causing SNPs in the human genome? 

# data[].attributes.headline
What changes occur over time in the genome and epigenome that lead to cancer over the many preceding years before a diagnosis? Can these be screened for effectively?

# data[].attributes.subject
What changes occur over time in the genome and epigenome that lead to cancer over the many preceding years before a diagnosis? Can these be screened for effectively?

# data[].attributes.headline
How can we use machine learning and deep learning approaches to inform how we combine genetic information to provide the best information about cancer risk? 

# data[].attributes.subject
How can we use machine learning and deep learning approaches to inform how we combine genetic information to provide the best information about cancer risk? 

# data[].attributes.headline
How do larger structural genetic variants (such as insertions, deletions, and duplications) contribute to cancer risk? 

# data[].attributes.subject
How do larger structural genetic variants (such as insertions, deletions, and duplications) contribute to cancer risk? 

# data[].attributes.headline
How can we best use information from studies with polygenic risk scores and rare variant data to discover novel cancer risk variants?

# data[].attributes.subject
How can we best use information from studies with polygenic risk scores and rare variant data to discover novel cancer risk variants?

# data[].attributes.headline
What genetic and environmental risk factors contribute to second cancer diagnoses?  

# data[].attributes.subject
What genetic and environmental risk factors contribute to second cancer diagnoses?  

# data[].attributes.headline
Cancer is an evolutionary process. Tumors develop through a process of somatic mutational selection and undergo additional selection under treatment. Can we harness evolutionary principles to better manage/treat cancer? 

# data[].attributes.subject
Cancer is an evolutionary process. Tumors develop through a process of somatic mutational selection and undergo additional selection under treatment. Can we harness evolutionary principles to better manage/treat cancer? 

# data[].attributes.headline
Why do germline susceptibility genes have such strong effects on particular tissues? (e.g. mismatch repair gene defects cause colon, uterine and bladder cancer and homologous recombination repair gene defects cause breast, ovarian, prostate and pancreatic cancer? 

# data[].attributes.subject
Why do germline susceptibility genes have such strong effects on particular tissues? (e.g. mismatch repair gene defects cause colon, uterine and bladder cancer and homologous recombination repair gene defects cause breast, ovarian, prostate and pancreatic cancer? 

# data[].attributes.headline
What are the unique independent and interactive contributions of structural, social, molecular, and genetic determinants of cancer among Asian American populations? 

# data[].attributes.subject
What are the unique independent and interactive contributions of structural, social, molecular, and genetic determinants of cancer among Asian American populations? 

# data[].attributes.body
Asian Americans comprise more than a third of the Bay Area population, and about a quarter of the cancer center catchment area population. Given their diversity and dynamic immigration patterns, leveraging their sociodemographic heterogeneity has the potential to provide insights into discovery of cancer risk factors.

# data[].attributes.headline
What are the genetic or epigenetic components of inflammation and immunity that affect the response of cancer patients to standard (e.g., radiotherapy, chemotherapy), or to more novel (e.g., immune therapy) cancer treatments?

# data[].attributes.subject
What are the genetic or epigenetic components of inflammation and immunity that affect the response of cancer patients to standard (e.g., radiotherapy, chemotherapy), or to more novel (e.g., immune therapy) cancer treatments?

# data[].attributes.body
Despite the broad evidence that TGFβ  promotes cancer via effects on cancer cells, the tumor microenvironment, and the anti-tumor immune response, why hasn't a clinical strategy for TGFβ inhibition in cancer been realized?

# data[].attributes.headline
How should oncologists best present cancer treatment options to older adults, who may value quality of life and maintaining independence more than longevity, to improve shared decision making and goal-concordant care?

# data[].attributes.subject
How should oncologists best present cancer treatment options to older adults, who may value quality of life and maintaining independence more than longevity, to improve shared decision making and goal-concordant care?

# data[].attributes.headline
How do cultural factors influence how older adults with cancer view aging and impairments identified by geriatric assessments? How do these cultural factors impact acceptability of geriatric assessment-driven interventions (e.g., physical therapy, nutrition)?

# data[].attributes.subject
How do cultural factors influence how older adults with cancer view aging and impairments identified by geriatric assessments? How do these cultural factors impact acceptability of geriatric assessment-driven interventions (e.g., physical therapy, nutrition)?

# data[].attributes.body
The vast majority of geriatric oncology studies nationally focus on predominately White, well-educated patient populations. UCSF's catchment area is uniquely diverse and can help answer these important questions.

# data[].attributes.headline
What is the best way to screen for and manage cancer treatment related peripheral neuropathy, especially among older adults at risk for falls?

# data[].attributes.subject
What is the best way to screen for and manage cancer treatment related peripheral neuropathy, especially among older adults at risk for falls?

# data[].attributes.headline
Does integrated geriatric and palliative care synergistically improve outcomes for older adults with cancer beyond what each resource provides individually?

# data[].attributes.subject
Does integrated geriatric and palliative care synergistically improve outcomes for older adults with cancer beyond what each resource provides individually?

# data[].attributes.body
Integrated geriatric and palliative care is a relatively unique resource at UCSF for older adults with solid tumors.

# data[].attributes.body
What fundamental research on the each of the many different protein machines that catalyze DNA repair in human cells would make possible the precise dissection of an individual tumor's hypermutabilty, so as to allow specific drug treatments to be used more effectively in personalized medicine -- analogous to the PARP inhibitor treatments for  BRCA1-type drivers of hypermutability?  How to increase the funding and priority given to the required in vitro reconstructions of these DNA repair systems by skilled protein biochemists? Might such a program be organized at UCSF?

# data[].attributes.headline
How should we screen for cognitive impairment among older adults with cancer and how should it be addressed once identified to best support patients and their caregivers?

# data[].attributes.subject
How should we screen for cognitive impairment among older adults with cancer and how should it be addressed once identified to best support patients and their caregivers?

# data[].attributes.body
Patients with cognitive impairment may be at higher risk for treatment toxicity due to difficulty following complex home medication instructions and treatment and imaging schedules. They are also at risk for both under- and overtreatment given the nuances of shared decision making. Wait lists for formal neurocognitive evaluation at UCSF are quite long and not practical for most older adults with cancer.

# data[].attributes.headline
How can we feasibly implement geriatric assessment in all UCSF hematology/oncology, surgical oncology, radiation oncology, and neurooncology clinics to improve outcomes for older adults with cancer?

# data[].attributes.subject
How can we feasibly implement geriatric assessment in all UCSF hematology/oncology, surgical oncology, radiation oncology, and neurooncology clinics to improve outcomes for older adults with cancer?

# data[].attributes.body
Geriatric assessment-driven interventions have been shown in large randomized trials to decrease treatment toxicity, improve quality of life, and reduce hospitalization and ED visits. However, practical barriers remain in these busy clinics and need to be overcome with novel implementation science approaches.

# data[].attributes.headline
Can in depth profiling of remarkable responders in the UCSF tertiary care population be used to advance cancer therapy?  

# data[].attributes.subject
Can in depth profiling of remarkable responders in the UCSF tertiary care population be used to advance cancer therapy?  

# data[].attributes.headline
Can patient-partnered research improve outcomes for rare cancers?

# data[].attributes.subject
Can patient-partnered research improve outcomes for rare cancers?

# data[].attributes.headline
Does improved quality of life (management of pain, depression, fatigue, etc) improve cancer mortality, and, if so, how?

# data[].attributes.subject
Does improved quality of life (management of pain, depression, fatigue, etc) improve cancer mortality, and, if so, how?

# data[].attributes.headline
What are the cell intrinsic and extrinsic mechanisms that drive preneoplastic progression to fully invasive cancer?

# data[].attributes.subject
What are the cell intrinsic and extrinsic mechanisms that drive preneoplastic progression to fully invasive cancer?

# data[].attributes.body
We know the genomic alterations are a major driver of cancer cells yet we can also find many of these same alterations within "normal" cells. Do the mutations need to arise in specific cell types? Do the cells need to be surrounded by a specific microenvironment to progress?

# data[].attributes.headline
What are the underlying mechanisms of resistance to standard therapies especially standard chemotherapy or radiation therapy and how can we overcome these differences in cancer response between individuals?

# data[].attributes.subject
What are the underlying mechanisms of resistance to standard therapies especially standard chemotherapy or radiation therapy and how can we overcome these differences in cancer response between individuals?

# data[].attributes.body
How can we stop cancer progression from precancerous lesions? Most oral cancers would be preventable

# data[].attributes.headline
How do access to standard clinical care, clinical trials, and novel therapeutics each mediate cancer survival disparities? 

# data[].attributes.subject
How do access to standard clinical care, clinical trials, and novel therapeutics each mediate cancer survival disparities? 

# data[].attributes.headline
What is the relationship between obesity and immune surveillance in cancer?  Is this organ context-dependent and does it impact response to immunotherapy?  

# data[].attributes.subject
What is the relationship between obesity and immune surveillance in cancer?  Is this organ context-dependent and does it impact response to immunotherapy?  

# data[].attributes.headline
What will be the effect of climate change on cancer prevention and control?

# data[].attributes.subject
What will be the effect of climate change on cancer prevention and control?

# data[].attributes.headline
For all major cancers can it be shown that inequities in outcomes (e.g, survival, QoL, and mortality) are similar for all peoples given equal access and quality of care?

# data[].attributes.subject
For all major cancers can it be shown that inequities in outcomes (e.g, survival, QoL, and mortality) are similar for all peoples given equal access and quality of care?

# data[].attributes.headline
What is the single most effective means of improving access for rural populations to advances in cancer prevention and early detection?

# data[].attributes.subject
What is the single most effective means of improving access for rural populations to advances in cancer prevention and early detection?

# data[].attributes.headline
How to address social determinants of health—participate in and study innovative efforts such as universal basic income, increasing diversity in employment, food and housing insecurity

# data[].attributes.subject
How to address social determinants of health—participate in and study innovative efforts such as universal basic income, increasing diversity in employment, food and housing insecurity

# data[].attributes.headline
What policy interventions can be introduced based on scientific evidence that the sugar industry marketing tactics are largely responsible for the obesity epidemic and increases in obesity-related cancers (e.g., breast, endometrium, liver)?

# data[].attributes.subject
What policy interventions can be introduced based on scientific evidence that the sugar industry marketing tactics are largely responsible for the obesity epidemic and increases in obesity-related cancers (e.g., breast, endometrium, liver)?

# data[].attributes.headline
What are the key molecular features of cancers in populations exposed to environmental toxicity, radiation and other contaminants, such as those living on top of superfund sites over decades? 

# data[].attributes.subject
What are the key molecular features of cancers in populations exposed to environmental toxicity, radiation and other contaminants, such as those living on top of superfund sites over decades? 

# data[].attributes.headline
Do markers of chronic stress (including adverse childhood events score (ACES)) correlate with the expression of important molecular targets, responses to chemotherapy,  immunotherapy, etc?

# data[].attributes.subject
Do markers of chronic stress (including adverse childhood events score (ACES)) correlate with the expression of important molecular targets, responses to chemotherapy,  immunotherapy, etc?

# data[].attributes.headline
What are the major causative cancer risk factors and how do these factors work together to influence individual cancer risk?

# data[].attributes.subject
What are the major causative cancer risk factors and how do these factors work together to influence individual cancer risk?

# data[].attributes.headline
What are the multi-level factors that influence availability of cancer clinical trials and how do these factors explain low rates of participation across all racial/ethnic groups? 

# data[].attributes.subject
What are the multi-level factors that influence availability of cancer clinical trials and how do these factors explain low rates of participation across all racial/ethnic groups? 

# data[].attributes.headline
How can we best incorporate germline genetic polygenic risk scores into cancer risk prediction models, including across different ancestral populations?

# data[].attributes.subject
How can we best incorporate germline genetic polygenic risk scores into cancer risk prediction models, including across different ancestral populations?

# data[].attributes.headline
What new interception methods can be developed to replace mammography for breast early detection (e.g. polygenic risk scores, ctDNA, liquid biopsies, imaging)? Same for prostate cancer?

# data[].attributes.subject
What new interception methods can be developed to replace mammography for breast early detection (e.g. polygenic risk scores, ctDNA, liquid biopsies, imaging)? Same for prostate cancer?

# data[].attributes.headline
How can we overcome intra-tumor heterogeneity (differences within a single tumor) to make cancer therapies work better?

# data[].attributes.subject
How can we overcome intra-tumor heterogeneity (differences within a single tumor) to make cancer therapies work better?

# data[].attributes.headline
What are deep physical principles governing cancer progression, and how do genes, cells, and their interactions contribute to these principles?

# data[].attributes.subject
What are deep physical principles governing cancer progression, and how do genes, cells, and their interactions contribute to these principles?

# data[].attributes.headline
What are the common mechanisms across tissues that promote tumors, and how can these mechanisms be targeted and, perhaps more importantly, prevented?

# data[].attributes.subject
What are the common mechanisms across tissues that promote tumors, and how can these mechanisms be targeted and, perhaps more importantly, prevented?

# data[].attributes.headline
Does blocking the condensate machinery offer a mechanism to block undruggable cancer targets?

# data[].attributes.subject
Does blocking the condensate machinery offer a mechanism to block undruggable cancer targets?

# data[].attributes.headline
How do we determine the system-wide effects of a clinical intervention - pathways, cells, organs...?

# data[].attributes.subject
How do we determine the system-wide effects of a clinical intervention - pathways, cells, organs...?

# data[].attributes.headline
Can the biology underlying autoimmune disorders inform us about mechanisms underlying immune-related AEs

# data[].attributes.subject
Can the biology underlying autoimmune disorders inform us about mechanisms underlying immune-related AEs

# data[].attributes.headline
How to deal with anti-science, disinformation for individuals and systems---how to change individual knowledge, behaviors, and beliefs, systematic disinformation, and channels/techniques on how to do it.

# data[].attributes.subject
How to deal with anti-science, disinformation for individuals and systems---how to change individual knowledge, behaviors, and beliefs, systematic disinformation, and channels/techniques on how to do it.

# data[].attributes.headline
How can we mitigate the adverse effects of cancer therapy?

# data[].attributes.subject
How can we mitigate the adverse effects of cancer therapy?