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Definition: An allergic reaction that causes inflammation, rashes and tissue damage.

Mechanism:

1. Antibodies (IgG/ IgM) combine with antigen forming, an immune complex.

2. Immune complex adheres to nearby cell.

3. Immune complex produce a c1 protein.

4. C1 protein splits into c5a and c3b.

1. C5a attracts Neutrophils;

2. C3b adhere to cell wall, marking where the Neutrophil should attack.

5. Neutrophils produce an enzyme, targeted at c3b.

6. The enzyme, cytotoxic granule breakdown the cells near c3b, triggering inflammatory reaction and tissue damage.

1. If reaction happen to skin tissue, rashes will form.

Example:

Farmer's Lung

Farmer inhale spore from mouldy hay, antibodies treat the spore as antigen, cause type 3 allergic reaction.

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reactions

Localised redness

blistering

swelling

( can lead to inflammation )

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Antibodies IgG or IgM will bind to antigens on surface of cells or tissues.

This may trigger an immune response that damages/destroys those cells.

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First exposure

allergn (dust,seafood) get into the body

Immune system reacting by produce antibodies IgE

It bind to basophils and surface of mast cell

The person doesn't show symptoms yet at first

Second exposure

Allergen re-enter the body

It bind to antibodies, and trigger driganulation

It release chemical substances like histamine that cause swelling, itching,running nose etc.

Leukotrienes and prostagladins cause inflammation and smooth muscle contraction