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Title for your research presentation topic. Three “take home messages (THM)” for the topic

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Lipids, how are they flipped across a membrane?

1. Flipping of lipids are essential for normal cellular function
2. Flippases are similar to the well known Iron-pumps
3. The flipping mechanism resembles a "credit card model"

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Comparing response rates, costs and selection bias when sending out questionnaires via traditional mail and secure digital mail

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Comparing response rates, costs and selection bias when sending out questionnaires via traditional mail and secure digital mail

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1. Digital invites (to e-boks) drastically lower costs
2. Traditional mail invites result in better response rates
3. Selection bias is not significant

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Fully automatic segmentation of arbitrarily shaped fiducials in CBCT projections

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Fully automatic segmentation of arbitrarily shaped fiducials in CBCT projections

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1. Tumor motion compromises radiation therapy.
2. Implanted markers are used to track tumors in 2D radiographs.
3. A 3D model of the marker improves the tracking accuracy

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How to
improve proton therapy planning of cancer patients?

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How to
improve proton therapy planning of cancer patients?

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1. Proton therapy can reduce the irradiation dose to the normal tissue surrounding the tumour

2. Dose calculations for proton therapy is very prone to errors

3. Dual energy CT images can potentially increase the accuracy of proton therapy dose calculations

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Surgery during pregnancy. A 20-year Danish population based prevalence study.

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Surgery during pregnancy. A 20-year Danish population based prevalence study.

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1. Increasing age, BMI and smoking increases risk of surgery during pregnancy.
2.There is a shift in timing of conduction of surgery on female reproductional organs
3. The prevalence of cesarean sections is increasing

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The importance of an acute blood screening for
drugs in poisoned patients with altered mental status

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The importance of an acute blood screening for
drugs in poisoned patients with altered mental status

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1. A new analysis method allows for a faster screening for drugs.
2. With the screening results available earlier, it could improve the treatment and observation level for the patients.
3. With a more adequatly chosen observation level, it might be possible to reduce the admissions to an Intensive-Care-Unit.

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Partnering - how are a partnership created with patient-controlled admission? 

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Partnering - how are a partnership created with patient-controlled admission? 

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1. PCA can create a partnership between mental health professionals' and patients

2. Partnering evolves in phases with focus on mental health professionals'  role and PCA frames

3. Demands joint responsibility so it does not turn into false security

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Maternal socioeconomic status and infant mortality with low
birth weight as a mediator: a nationwide study of Denmark and Scotland using
administrative data 

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Maternal socioeconomic status and infant mortality with low
birth weight as a mediator: a nationwide study of Denmark and Scotland using
administrative data 

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1. Low maternal socioeconomic status (SES) is partly acting via increased low birth weight (LBW) in increasing infant mortality

2.LBW is more predictive of death in the near future (neonatal) than post-neonatal death and the considerable direct effect of SES on post-neonatal mortality could reflect persisting SES disparities in the care of infants.

3.To minimize social inequalities in infant mortality, intervention should be aimed to address prenatal risk factors for low birth weight and improve the care of infant after birth mortality.

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Differences in lung cancer management what, where and why?

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Differences in lung cancer management what, where and why?

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1. Cerebral imaging practice is different in different parts of Denmark.
2. Guidelines are different between the Nordic countries
3. Low level of evidence in recommendations form relevant research questions

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A Novel standardised 3D analysis to assess cleft size at birth, based on digital models of unilateral cleft lip and palate patients.

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A Novel standardised 3D analysis to assess cleft size at birth, based on digital models of unilateral cleft lip and palate patients.

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1. No consensus has been reached yet on how to measure cleft size
2. Laser scanned digital infant models casts offer the possibility for a 3D analysis of cleft size
3. The "3D Infant Cleft Severity Ratio" may have an important diagnostic and prognostic value

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Sensing of pathogen-derived DNA by IFI16 and cGAS. 

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Sensing of pathogen-derived DNA by IFI16 and cGAS. 

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1. Sensing of foreign DNA is essential for clearance of  foreign microbe.
2. Sensing is facilitated by the cGAS enzyme.
3. IFI16 enhances cGAS function.

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Influence of vasopressors on brain
oxygenation and microcirculation

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Influence of vasopressors on brain
oxygenation and microcirculation

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1.  Cerebral vasoconstriction decreases SctO2

2.  Difference between alfa- and beta- agonist drugs on brain

3.  The new brain parameter: Capillary transit time heterogeneity

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Can genes predict toxicities to asparaginase treatment?

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Can genes predict toxicities to asparaginase treatment?

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1. Be absolutely sure about your phenotype when you do a GWAS study
2. The children who develop an allergic reaction to asparaginase have a different genetic profile.
3. The genes could be the key to a more individualized treatment

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Offering
HPV self-sampling in the Danish cervical cancer screening
program

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Offering
HPV self-sampling in the Danish cervical cancer screening
program

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1. The overall participation rate in the screening program is currently only 64%. Further, nearly half of all newly diagnosed cervical cancers in Denmark are found among under-screened women.

2. This study will evaluate the effect on participation in the Danish screening program of offering a HPV self-sampling kit to non-participants  compared with the standard second reminder for routine screening.

3.This study will provide important evidence if and how HPV self-sampling can be used to increase participation rate in the Danish screening program, and thereby reduce the number of deaths caused by cervical cancer.

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Socioeconomic
inequality in the provision of best clinical practice in the treatment of
stroke patients

 

 

 
         

            

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Socioeconomic
inequality in the provision of best clinical practice in the treatment of
stroke patients

 

 

 
         

            

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1) Socioeconomic disparities in health can be enforced by the health care system

2) Health care services may be unequally distributed among stroke patients of different socioeconomic status

3) A decade of process monitoring may have improved equality in stroke treatment

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Chemotherapy-induced peripheral neuropathy (CIPN)  – Understanding risk factors 

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Chemotherapy-induced peripheral neuropathy (CIPN)  – Understanding risk factors 

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1.     CIPN is prevalent in 43% 1-year after chemotherapy
2.     CIPN symptoms are tingling, numbness and allodynia
3.     Risk factors for CIPN are poorly understood

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Leukocytes in platelet-rich plasma increases proliferation in human chondrocytes

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Leukocytes in platelet-rich plasma increases proliferation in human chondrocytes

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1. High leukocyte concentration in platelet-rich plasma (PRP) increases chondrocyte proliferation.
2. Inclusion of leukocytes in PRP shows no effect on chondrogenic gene expression.
3. Exclusion of red blood cells leads to changes in leukocyte composition in PRP.

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Changes
in the shoulderfunction after constraint-induced movement therapy (CIMT)

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Changes
in the shoulderfunction after constraint-induced movement therapy (CIMT)

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1. CIMT is a highly recommended intensive training for people with reduced arm- and hand-function following stroke

2. Kinematic studies that can show specific changes in movement components due to CIMT are asked for

3. 3D kinematic measurements allows for specific measurements and kvantification of the movements in the shoulder

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1. Invasive candidiasis is preceded by colonisation
2. Two kinds of candida pneumonia divided by means of contamination
3. Candida pneumonia is extremely rare.

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Reducing breast cancer mortality by improving breast cancer screening satisfaction?

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Reducing breast cancer mortality by improving breast cancer screening satisfaction?

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1. The mortality rate from breast cancer in Denmark is the highest in Northern Europe
2. Satisfaction with breast cancer screening affects participation
3. High level of service in screening can increase satisfaction

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Diagnosing ovarian cancer- can we make the diagnosis earlier?

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Diagnosing ovarian cancer- can we make the diagnosis earlier?

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1. Kill the silence
2. Remember more than 90 % of ovarian cancers present with symptoms prior to diagnosis
3. Symptoms are several, frequent and more resent onset.

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The impact of spirometry in the Ebeltoft Health Promotion Study 1.COPD patients have a significant lower lung function 15 years ahead of their diagnosis compared with non-COPD patients 2. More self reported symptoms  and more smoker among COPD compared with non-COPD 3. room for improvement 3. Early detection of COPD is difficult

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The impact of spirometry in the Ebeltoft Health Promotion Study 1.COPD patients have a significant lower lung function 15 years ahead of their diagnosis compared with non-COPD patients 2. More self reported symptoms  and more smoker among COPD compared with non-COPD 3. room for improvement 3. Early detection of COPD is difficult

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Discovering the patient pathway for recurrent cancer.

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Discovering the patient pathway for recurrent cancer.

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1)       In order to provide qualified post cancer follow up programmes in general practice, we need more evidence on the patient pathway for recurrent cancer.
2)     Research in the diagnostic route for cancer recurrence is challenging, since registration of cancer recurrence in  the patient registries is unsystematic and incomplete.
3)      Using Danish national patient registries, we will develop a method to identify patients with recurrent cancer, hence enable research in the diagnostic route to cancer recurrence.