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Uses of ligands in medicine

What are ligands?

The ligand is element usually metal attached to a central element or atom in a coordinate bonding  and act as the donor of the electron pair.

ligands have features and applications that help facilitate targeting, diagnosing, and treating diseases.

Therapeutics

Ligands are used in therapeutics : anticancers and developing a controlled or improved toxicity levels. Radioimmunotherapy,  is one example of  targeted therapeutics.

Antibodies

Legends are also used  in advanced Medical engineering of a fully humanized antibodies which is away to avoid  the immune response for foreign antibodies

Micro Reservoir System

Ligands are also applied to the micro Reservoir system and liposomes which are substances made to penetrate the cell in order to deliver a specific  medication or drug, it can be used as a way to create to allow sustained release of this drug or therapy inside the body, The more basic research is needed in order to understand how this side effect the body and understand how to optimise  sustained drug release rates.

https://www.britannica.com/science/ligand

https://www.technology.matthey.com/article/52/1/21-22/

https://www.wiley.com/en-us/Ligand+Design+in+Medicinal+Inorganic+Chemistry-p-9781118488522

https://www.khanacademy.org/science/biology/cell-signaling/mechanisms-of-cell-signaling/a/signal-perception

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A Liigand in medicine is a molecule that connects to another molecule. which is usually a soluble molecule such as a hormone or neurotransmitter that binds to a receptor.

Ligands can be widely used in the Medicinal field. For example, the titanocene dichloride is already being used in clinics in addition to antimetastatic activity and a range of Ru(III) complexes are also being used. There are ways to minimize the toxicity of Gd(III) complexes and therefore they can be safely injected as MRI contrast agents.

These Ligand designs helps in many ways. Such as directing any paramagnetic ions to be targeted to specific organs. These Ligands can also enable the targeting of  radiodiagnostic (99mTc) and radiotherapeutic (186Re) isotopes.

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I totally agree with what Jana pointed out....
But I have a question. According to what I redd and what I noticed Jana read too, ligands have applications just like isotopes, so what makes them so special??

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I fully ahgree with what Jana pointed out...
I also have a question ... Why are ligands so special I mean after reading what Jana said I believed even more that they're used for the same 2 uses of isotopes. Then what makes them so unique

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I currently cant see the comment icon.. it's not avaliable

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Jana Tarek

Cancer
A ligand is an ion or a molecule that is attached to an atom by coordinative boding. Further into the advances in medicinal chemistry, a one shall notice that ligands have been utilized in the field od medicine  for diagnosis and therapy. Medical scientists have come to a new discovery of a molecule that bind two protein with different affinities to localize cancer tumors without affecting healthy tissues. In regards to prostate cancer, the new  RPS-027 ligand binds to the PSMA, so called "prostate specific membrane antigen, promising to maintain an excellent tumor targeting with protection to other sensitive organs from alpha radiation. To put it differently, the goal of such ligand is to minimize the damage of healthy cells while conducting therapy. - https://medicalxpress.com/news/2017-09-ligands-prostate-cancer.html

Diagnostic imaging

Safely injecting Gadolinium ion, Ge+3 which is very toxic, into patients is an advance in diagnosis. Ge ion has the ability to strongly bind to "multidentate chelated ligands, while still having sufficient room in its coordination sphere to bind and relax water."- https://www.technology.matthey.com/article/52/1/21-22/

i'd finally like to point out the minimal info I found about ligands utilization in medicine.

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Medical Uses of Ligands

What are some medical uses of ligands?!

1-      Cancer therapy

2-      Diagnostic imaging

3-      Treats hypertension

4-      Used in metal containing

5-      Used as nonsteroidal anti-inflammatory drugs

6-      Used to create multi-therapeutic medicines

How can ligands be used in multi-therapeutic medicines?!

First of all multi-therapeutic medicines are medicines that can cure several diseases by containing more than 1 compound that targets more than one disease in the same body at the same time. Those kinds of medicines are great because they help doctors reduce the medicine or drug damage on the patient’s body organs. Ligands help doctors create those medicines in a very simple way. When doctors need 2 compounds in a patient’s body and the 2 compounds can form a dative bond, the doctors then inject the patients with the 2 compounds at the same time with one needle, and then as the complex compound is ingested, the bond dissociates into different tissues curing several diseases at once.

How can ligands be used as cancer therapy?!

There is a kind of ligand called PPAR which is primarily used to cure cancer in cells. When a cell has cancer specific genes are activated which show the cancer symptoms, and those PPAR ligands along with another substance called RXR, have the ability to activate or deactivate genes in cells, hence when patient starts to have cancer, doctors may inject their bodies with the activated cancer gene with PPAR ligands and RXR which deactivate this cancer gene, and this cures cancer in the patient’s body because cells which used to divide continuously now divide in normal rates.

Comment about other’s work

Since I was the first one to add my work to the paddle, I can’t really comment much on my colleagues work, but they defiantly are going to write about one of the medical uses I read about because those uses are generally limited, and this allows me to in way comment about their work. All the uses in which ligands are used for are very simple, yet greatly affect us. For example how ligands can treat cancer simply by deactivating a gene or how it can save a person’s life from poisoning by not allowing the cell to absorb metals. All these functions or uses are simple, yet greatly affect our lives

Resources

URLhttps://www.ukessays.com/essays/biology/application-of-coordination-compound-in-medicines-biology-essay.php

Website TitleUKEssays

Article TitleApplication Of Coordination Compound In Medicines Biology Essay

Date AccessedOctober 03, 2018

URLhttps://www.technology.matthey.com/article/52/1/21-22/

Website TitleJohnson Matthey Technology Review

Article Title"Medicinal Applications of Coordination Chemistry"

Date AccessedOctober 03, 2018

URLhttps://www.hindawi.com/journals/ppar/2008/181047/

Website TitleAdvances in Decision Sciences

Article TitleSynergistic Effects of PPAR Ligands and Retinoids in Cancer Treatment

Date PublishedMay 28, 2008

Date AccessedOctober 03, 2018

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Research the uses of Ligands in medicine.
Choose one of the applications and discuss it in details.
Comment on one of your colleagues research
ATL skills assessed:

•Communication Skills Negotiate ideas and knowledge with peers and teachers

•Self Management :Organization, Select and use technology effectively and productively

•Research Skills: Understand and use technology systems