# data[].attributes.location_name
UFRGS - Universidade Federal do Rio Grande do Sul - Farroupilha, Porto Alegre - RS

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Name

LBCM - Laboratory of Computational and Molecular Biology

Lead Professor

Diego Bonatto

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/2915446717051640

Contact

diego.bonatto@ufrgs.br

Region

South

State

Rio Grande do Sul

City

Porto Alegre

Institution

UFRGS - Federal University of Rio Grande do Sul

Description

We develop molecular tools for the generation of new strains of industrial microorganisms. Our focus is on the generation of vectors for gene editing in yeasts of industrial interest, also focusing on the development of eukaryotic polycistronic operons for the production of carotenoids, xylose metabolism and generation of 2nd and 4th generation ethanol.

Research Lines

Gene editing in yeasts of industrial interest

Generation of polycistronic expression devices for the synthesis of carotenoids in yeasts

Generation of xylose-fermenting yeast strains

Links

coming soon

# data[].attributes.location_name
UFF - Instituto Biomédico - Rua Professor Hernani Melo - São Domingos, Niterói - RJ

# data[].attributes.body
Name

BacMar - Marine Bacteriomas

Lead Professor

Bruno Francesco Rodrigues de Oliveira

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/0409870707537485

Contact

bfroliveira@id.uff.br

Region

Southeast

State

Rio de Janeiro

City

Niterói

Institution

UFF - Fluminense Federal University

Description

The Marine Bacteriomas Laboratory (BacMar) is dedicated to investigating the ecology, genomics and biotechnology of prokaryotic microbiomes associated with marine holobionts, in particular the macroalgal host. Using culture-dependent (culturomics) and culture-independent (metataxonomics and metagenomics) strategies, we focused our efforts on characterizing the diversity, structure, composition, and ecophysiology of cultivable and non-cultivable bacterial and archaeal communities associated with different taxa of naturally occurring macroalgae in coastal regions of the state of Rio de Janeiro and other points along the Brazilian coast. Combining classical approaches in microbial bioprospecting with large-scale genome sequencing, we conducted screening, genome mining, production, extraction, and chemical and functional characterization of bioproducts from the cultivable bacterial strains isolated in our work, with special attention to antimicrobial, antibiofilm, antivirulence, enzymes, biosurfactants, bioemulsifiers, and biopolymers with applications in biomedicine, environmental protection, and in several industrial sectors. In particular, carbohydrate-active enzymes (CAZymes) typically found in marine habitats are especially targeted by our group, from their identification in bacterial genomes to their complete purification and applications in a biorefinery context. We are also particularly interested in understanding the ecology, evolution and dynamics of pangenomes of marine bacterial models, deriving relevant inferences both for understanding the biology of these organisms and for guiding their future biotechnological exploitation. We hope to integrate knowledge from our main research lines and incorporate synthetic biology tools to provide solutions ranging from elucidating the interaction between symbiotic microorganisms and their hosts in marine ecosystems to enabling and accelerating the sustainable production of high-value bioproducts by marine bacterial strains.

Research lines

Microbiology of marine macroalgae: diversity, ecophysiology and biotechnology

CAZomes of marine microbiomes: genomics, biochemistry and industrial applications

Bacterial pangenomes

Links

dgp.cnpq.br/dgp/espelhogrupo/8711330160766580

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UFRJ - Faculdade de Letras - Avenida Horácio Macedo - Cidade Universitária, Rio de Janeiro - RJ

# data[].attributes.headline
Biological Systems Engineering UFRJ - Rio de Janeiro, RJ

# data[].attributes.subject
Biological Systems Engineering UFRJ - Rio de Janeiro, RJ

# data[].attributes.body
Name

Biological Systems Engineering

Lead Professor

Maria Alice Zarur Coelho

Lattes (Brazilian academic CV system)

lattes.cnpq.br/7892919789980668

Contact

alice@eq.ufrj.br

Region

Southeast

State

Rio de Janeiro

City

Rio de Janeiro

Institution

UFRJ - Federal University of Rio de Janeiro

Description

It is part of the Department of Biochemical Engineering of the Federal University of Rio de Janeiro. It is dedicated to dealing with different aspects related to microbiology, biochemical kinetics, modeling and optimization that lead to improved productivity in bioprocesses. Some tools are used in the research activities of the BIOSE laboratory: digital image analysis in microbiology; monitoring systems for bioprocesses; modeling and optimization (unstructured and structured approaches); multiphase systems (fluorinated compounds and ionic liquids) applied to microbiology.

Research lines

Responses to cellular stress

Digital image analysis applied to biological systems

Obtaining enzyme bioproducts in multiphase systems

Biovalorization of agro-industrial waste

New solvents (fluorinated compounds and ionic liquids) in biological systems

Biodegradation and biodepolymerization of recalcitrant compounds (plastics, herbicides, crude oil)

Links

http://www.biose.eq.ufrj.br/

https://www.instagram.com/biose_ufrj/

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UNILA Jardim Universitário - Avenida Tarquínio Joslin dos Santos - Polo Universitário, Foz do Iguaçu - PR

# data[].attributes.body
Name

SynFronteras

Lead Professor

Cristian Antonio Rojas

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/6076965755184335

Contact

cristian.rojas@unila.edu.br

Region

South

State

Paraná

City

Foz do Iguaçu

Institution

UNILA - Federal University of Latin American Integration

Description

A group of people fascinated by synthetic biology and its possibilities to transform society. We are beginning our journey, dedicated to learning and innovating. Our goal is to become a regional reference, applying our knowledge to solve local problems and contribute to the scientific and technological advancement of the triple frontier.

Research lines

Detection and monitoring systems;

Protein expression.

Links

https://www.instagram.com/igem_synfronteras/

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UnB Departamento de Genética e Morfologia - Brasília, DF

# data[].attributes.body
Name

SynBioLab UnB

Lead Professor

Cíntia Marques Coelho

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/9351785093396394

Contact

cintiacoelhom@unb.br

Region

Central-West

State

Federal District

City

Brasília

Institution

UnB - University of Brasilia

Description

Our group is formed by several researchers, PhD, master's and scientific initiation students, with the objective of developing tools in the area of ​​synthetic biology for prokaryotic and eukaryotic organisms.

Research Lines

Design and testing of genetic switches for the control of gene regulation in eukaryotic cells

Development of detection methods free of enzymatic activity and cellular environment for the detection of viral RNA

Development of computer programs and other tools for genomic engineering of prokaryotic and eukaryotic organisms

Evaluation of the CRISPR-Cas9 suicide system as a tool for editing genes encoding histone deacetylases in Cryptococcus neoformans

Links

www.synbiolabunb.com

https://www.instagram.com/synbiolab.unb/

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STN Embrapa Recursos Genéticos e Biotecnologia - Brasília, DF

# data[].attributes.headline
STN Embrapa Genetic Resources and Biotechnology - Brasília, DF

# data[].attributes.subject
STN Embrapa Genetic Resources and Biotechnology - Brasília, DF

# data[].attributes.body
Name

INCT (National Institute of Science and Technology) - BioSyn

Lead Professor

Elíbio Rech

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/0995074904257272

Contact

elibio.rech@embrapa.br

Region

Central-West

State

Federal District

City

Brasília

Institution

Embrapa Genetic Resources and Biotechnology

Description

Omics and synthetic domestication of specific traits of Brazilian biodiversity targeting conservation, engineering and economics. INCT-BioSyn was established and funded by the Brazilian Ministry of Science, Technology and Innovation.

Research Lines

Bioprospecting of genes from metagenomic data of samples of Brazilian biodiversity through AI

Bioengineering of spider silk proteins for the development of smart biomaterials

Construction and evaluation of genetic circuits in eukaryotic cells

Production of proteins of economic interest in a cell-free system

Studies and development of synthetic cells with specific biological functions (JCVI-syn1.0 and JCVI-syn3A)

Links

coming soon

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UFABC - Universidade Federal do ABC - Avenida dos Estados - Bangú, Santo André - SP

# data[].attributes.body
Name

LGEM - Genetics and Metabolic Engineering Laboratory

Lead Professor

Juliana Cardinali Rezende

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/2698272337010554

Contact

j.cardinali@ufabc.edu.br

Region

Southeast

State

São Paulo

City

Santo André

Institution

UFABC - Federal University of ABC

Description

Develops research related to prospecting (cloning-sequencing by Sanger method; Next-Generation Sequencing (NGS); Denaturing gradient gel electrophoresis (DGGE); Amplified Ribosomal DNA Restriction Analysis (ARDRA); Real-time PCR (qPCR)), quantification (Real-time PCR; Fluorescence In Situ Hybridization (FISH); catalyzed reporter deposition FISH (CARD-FISH)), metabolism analysis and construction of in silico metabolic networks of microorganisms with high biotechnological potential from environmental samples, urban solid waste, domestic sewage, industrial waste, etc. Experience in gene sequencing (Sanger) and genomes using NGS platforms. The objective is to isolate bacterial strains of interest that will be used in the optimization of waste treatment and bioremediation processes, and/or genetically improved to be used in the production of bioproducts of interest and with high added value, such as biodegradable biopolymers (Polyhydroxyalkanoates - PHAs), polyphosphates, biomolecules with diverse activities, etc. In this context, the researcher's group works with genomics, metagenomics, transcriptomics, quantification of gene expression and microbial communities, construction of genetically modified organisms (GMOs) from random or directed mutagenesis (suicide vectors and Crispr), overexpression and/or heterologous expression of genes and metabolic pathways in bacterial strains such as E. coli, Pseudomonas sp., Halomonas sp., Burkholderia sp., Beigerinchia sp., etc., aiming at optimizing the bioprocess or producing new bioproducts.

Research Lines

Genetics

Genomics

Microbial Ecology

Metabolic Engineering

Bacterial Metabolism

Production of Bioproducts

Biotechnology

Links

https://www.ufabc.edu.br/ensino/docentes/juliana-cardinali-rezende#

# data[].attributes.location_name
UFABC - Universidade Federal do ABC - Avenida dos Estados - Bangú, Santo André - SP

# data[].attributes.body
Name

SynBio UFABC

Lead Professor

Milca Rachel da Costa Ribeiro Lins

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/7637640110741775

Contact

milca.lins@ufabc.edu.br

Region

Southeast

State

São Paulo

City

Santo André

Institution

UFABC - Federal University of ABC

Description

Modern Biotechnology uses approaches such as Synthetic Biology to achieve objectives inherent to the area, including the replacement of non-sustainable procedures with sustainable ones and the use of rationally designed microorganisms as workhorses for the production of various bioproducts with added value. Thus, our laboratory's mission is to explore the frontiers of synthetic biology, aligning biological knowledge with engineering tools to create innovative solutions. To this end, we use traditional and modern tools from molecular biology and genetic engineering to develop projects.

Research lines

Construction of synthetic gene circuits for regulating gene expression;

Biosensors based on synthetic gene circuits;

Synthetic biology applied to prokaryotic metabolic engineering.

Links

https://dgp.cnpq.br/dgp/espelhogrupo/804621

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UFSCar - Universidade Federal de São Carlos - Rodovia Washington Luís - Monjolinho, São Carlos - SP

# data[].attributes.body
Name

Cellular Factory Laboratory (LaFaC)

Lead Professor

Adilson J. Silva

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/3447469350644179

Contact

adilsonjs@ufscar.br

Region

Southeast

State

São Paulo

City

São Carlos

Institution

UFSCar - Federal University of São Carlos

Description

The Cellular Factory Laboratory (LaFaC) works on the development of bioprocesses within the context of biorefineries. Thus, the work developed aims at the construction and optimization of genetically modified strains of microorganisms (known as cellular factories) for the conversion of byproducts from biofuel production into compounds of greater commercial value. To this end, bioinformatics tools and Metabolic Engineering strategies are used for in silico selection and in vivo implementation of genetic modifications that lead to the development of efficient microbial strains for the proposed objective.

Research lines

Production of bioproducts in E. coli and Xanthomonas sp. Ex: aromatic compounds (phenazines), organic acids (3-HP), biocolorants (indigoidine), and biopolymers (xanthan gum and hyaluronic acid).

Use of metabolic models for the design of cellular factories

Links

https://www.lafac.ufscar.br/

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Genomics and Experimental Evolution of Yeast - Santana, Rio Claro - SP

# data[].attributes.headline
Genomics and Experimental Evolution of Yeast - Rio Claro - SP

# data[].attributes.subject
Genomics and Experimental Evolution of Yeast - Rio Claro - SP

# data[].attributes.body
Name

Laboratory for Genomics and Experimental Evolution of Yeasts

Lead Professor

Jeferson Gross / Ana Paula Jacobus

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/8907674497236657 | http://lattes.cnpq.br/1046841441527171

Contact

jeferson.gross@unesp.br | ana.jacobus@unesp.br

Region

Southeast

State

São Paulo

City

Rio Claro / São Paulo

Institution

UNESP - Paulista State University / SENAI Biotechnology

Description

The Laboratory has research activities using Saccharomyces cerevisiae and Escherichia coli in the development of biotechnological tools, such as CRISPR/Cas9, and in conducting laboratory adaptive evolution experiments and yeast genomics. In addition to research in genetic modification technologies and evolutionary biology approaches, the group aims to develop microbial strains for industrial biotechnological applications, such as in the production of biofuels and renewable chemicals via fermentation.

Research Lines

Adaptive Laboratory Evolution (ALE) with S. cerevisiae (ethanol tolerance, lignocellulosic hydrolysates, synthetic yeasts);

Adaptive Laboratory Evolution (ALE) with E. coli (Sucrose assimilation engineering);

EasyGuide CRISPR for S. cerevisiae and E. coli (PCR and Oligo-based approach);

EasyGuide expanded for S. cerevisiae (Synthetic oligo pools, Multiparallel CRISPR interference/activation, Parallel site-directed mutagenesis (protein directed evolution))

Links

https://yeastevolution.wixsite.com/yeastevolution

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FCF - Faculdade de Ciências Farmacêuticas - Câmpus de Araraquara - Unesp - Rodovia Comandante João Ribeiro de Barros - Campos Ville, Araraquara - SP

# data[].attributes.body
Name

SynBio Araraquara

Lead Professor

Dr. Danielle B. Pedrolli

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/7721039814884365

Contact

danielle.pedrolli@unesp.br

Region

Southeast

State

São Paulo

City

Araraquara

Institution

UNESP - Paulista State University

Description

The SynBio Araraquara research group has been working since 2015 on the development of biological parts to compose biological circuits that lead to the development of new functions for engineering biological systems, both cellular and cell-free. The group works mainly on the development of biosensors and bioproducts with pharmaceutical, cosmetic and food applications. The group also develops tools for teaching biotechnology and synthetic biology, using digital manufacturing tools. The professor responsible is the founder and coordinator of the FCF-Unesp Open Space, a makerspace for development focused on Biotechnology. She is also the PI of the iGEM Unesp team.

Research lines

Development of biological parts and circuits for metabolic engineering and development of biosensors

Engineering of cellular and cell-free biological systems for the production of bioproducts and biosensors

Development of tools for teaching biotechnology and synthetic biology

Links

https://www2.fcfar.unesp.br/#!/english/faculty/profile/v/id::567/name::danielle-biscaro-pedrolli/tab::bio

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Av. Prof. Lúcio Martins Rodrigues, 370 - Butantã, São Paulo - SP, 05508-020

# data[].attributes.body
Name

Center for Synthetic and Systems Biology - S2B

Lead Professor

Marcos Buckeridge

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/9650392075455314

Contact

msbuck@usp.br

Region

Southeast

State

São Paulo

City

São Paulo

Institution

USP - University of São Paulo / Inova USP

Description

Application of Synthetic and Systems Biology in technological and scientific development for incremental and disruptive innovation in the area of ​​generating processes, products and materials in a sustainable and biological way, seeking solutions based on nature. Use, improvement and application of biomass or its derivatives in the generation of sustainable products and processes.

Research lines

CO2 valorization, catalysis, physical-chemical measurements of gas mixtures

Genomics and development of molecular markers

Effluent bioremediation

Pigment production

Sugarcane biotechnology

Product and process design for bioproducts

Bioremediation and use of waste

Use of food and agro-industrial waste to produce biodegradable and biocompatible polymers

Optimization of process operations/Product development/Modeling of chemical and biological reactors

Software development

Synthesis of nanoparticles and bionanoparticles

Production of biofertilizers and agricultural biostimulants

High-pressure technology, catalysis, development of catalytic processes, supercritical fluids and physicochemical measurements of gas mixtures

Links

https://inova.usp.br/iniciativas/s2b/

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Laboratório De Genômica e bioEnergia (LGE) - Cidade Universitária, Campinas - SP

# data[].attributes.headline
Genomics and Bioenergy Laboratory (LGE) -Campinas, SP

# data[].attributes.subject
Genomics and Bioenergy Laboratory (LGE) -Campinas, SP

# data[].attributes.body
Name

Laboratory of Genomics and Bioenergy (LGE)

Lead Professor

Dr. Gonçalo Amarante

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/5775091545458540

Contact

giomaklouf@gmail.com

Region

Southeast

State

São Paulo

City

Campinas

Institution

UNICAMP - State University of Campinas

Description

Founded in 1997, the Laboratory of Genomics and Expression (LGE) at UNICAMP stands out as a center of excellence in bioenergy research. Under the leadership of Prof. Dr. Gonçalo Amarante Guimarães Pereira, the LGE brings together more than 50 highly qualified researchers, dedicated to developing innovative and sustainable solutions for the challenges of the energy future.

Research Lines

Biomass: Plant biomass is an essential source of clean energy, crucial for a sustainable energy matrix independent of fossil fuels in Brazil. LGE seeks to increase biomass production for bioenergy without expanding the planted area, with research into sugarcane and alternatives such as agave, leading the BRAVE Project (Brazil Agave Development) since 2022.

Yeast: We develop efficient yeasts for fermentation and production of ethanol and other bioproducts, using molecular biology and synthetic biology techniques.

Bioinformatics: We use bioinformatics to analyze omics data, identifying molecular markers and enzymes to improve plants and ethanol production processes.

Links

https://www.lge.ibi.unicamp.br/

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UNICAMP Universidade Estadual de Campinas - Cidade Universitária Zeferino Vaz - Barão Geraldo, Campinas - SP

# data[].attributes.body
Name

Synthetic Biology of Microorganisms applied to Biotechnology - SyMBio

Lead Professor

Leandro Vieira dos Santos

Lattes (Brazilian academic CV system)

http://lattes.cnpq.br/6507172974225755

Contact

leandro.vieiradossantos@manchester.ac.uk

Region

Southeast

State

São Paulo

City

Campinas

Institution

UNICAMP - State University of Campinas / University of Manchester

Description

The SyMBio group is structured to develop and apply synthetic biology tools to modify microorganisms as cellular platforms for biotechnological applications (Synthetic Biology of Microorganisms applied to Biotechnology – SyMBio). In this context, the group uses the interface between synthetic biology, metabolic and evolutionary engineering, physiology and systems biology to: i. design new synthetic biology tools to modify microorganisms; ii. design new metabolic pathways and flows in industrial yeasts for the production of high-value-added bioproducts; iii. engineering transporters for efficient assimilation of sugars derived from biomass; iv. elucidating new molecular mechanisms of tolerance to multiple stresses in yeast.

Research lines

Design of new synthetic biology tools applied to yeast metabolic engineering;

Metabolic engineering and evolution of industrial yeasts for the production of high-value-added biocompounds;

Molecular mechanisms of tolerance to stresses in industrial bioprocesses.

Links

coming soon