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The FBI’s biometric analysis and tools include the Combined DNA Index System . (CODIS) allows labs to exchange and compare DNA profiles to link crimes to each other and the suspect/perpetrator.

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(DCU) provides forensic DNA examinations to the FBI such as testing to detect and characterize body fluids such as blood and semen on items of evidence, Casework works with Mitochondrial DNA (mtDNA) is a form of DNA that is transmitted from mother to child which means you and a sibling can have the same mtDNA profile, Y-chromosome DNA which test for sexual assult cases, and lastly, Nuclear DNA (nDNA) which is typically analyzed in evidence containing body fluids, skin cells, bones, and hairs.

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in October 2016, FDDU began to issue a new and smaller oral DNA collection device. this device allows for a direct transfer from inside of the cheek. Also confirmations against individuals whose profiles are in the National DNA Index System (NDIS) who submit blood because they have to do so, have DNA profile the FDDU produced and uploads it to the Combined DNA Index System (CODIS).

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the casework laboratory can request FDDU to confirm the suspect sample DNA profile to figure out whos DNA was at the crime scene. Once the profile is confirmed, the FDDU will then release the suspect's personal identifying information back to the casework laboratory

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Latent Print Unit of the laboratory conducts scientific examinations on friction ridge impressions which can be left when a person touches an object with their hands or feet. The friction ridges that are invisible to the naked eye are called latent prints. known as friction ridge analysis. Latent prints are heavily used in the FBI , and  fingerprints are usually the first thing that is taken as evidence and sent through biometric analysis.