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1) Diphenhydramine - A potent antihistamine and antitussive with anticholinergic properties.

2) Levomenthol - Contains mild local anaesthetic and decongestant properties.

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Diphenhydramine hydrochloride Slowly darkens on exposure to light, however Stable under normal conditions

- Solutions are packaged into an amber container that don’t allow the light transmission to reduce photooxidation of the solutions

-The main stability concerns of Diphenhydramine are the potential hydrolysis of the ether group and oxidation of the ether, aromatic groups and amine also oxidised to a carboxylic acid, Diphenhydramine Oral Solution should be protected from light.

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-child lock safe lid to prevent overdose of drug on the child since its sweet, they might want to keep having it when at inappropriate times

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- glass bottles are temperature resistant so it extend the lifetime and non reactive to chemicals so there will be no leakage of matter into the liquid. -Some plastic containers start to interact with the medicine but Glass can be easily sterilised and since its resistant to high temp it can be boiled to kill any harmful bacteria

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- cautions/ warnings
- description of uses of medicine
- possible side effects
- states what it is used for; provides effective relief from childrens cough and congestion. Also helps relives runny nose

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1.) 0.55mg in 5ml
2.) Liquid form in Syrup
3.)Null
4.) Slightly soluble in water
5.) Null
6.)Null
7.)Alcohol(OH-), Methyl(CH3-)

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-Sodium benzoate

-Citric acid monohydrate

-Sodium citrate

-Saccharin sodium

-Sodium -carboxymethylcellulose -7MXF

-Glycerol

-Sorbitol 70% (non -crystalline)

-Concentrated raspberry -essence (Ethanol, -Propylene Glycol E1520)

-Ethanol 96%

-Purified water

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1.) Conc in medicine is 7.0 mg in 5ml
2.) Liquid form in syrup
3.) Null
4.)It is not miscible with water.
5.)Null
6.)Null
7.) Functional groups are amines (NH-), Amine Salts,  Ethers, Oxides

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Classes of excipients

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- The age at which children take tablets or capsules is a factor of importance to their safety so that inadvertent inhalation and choking are avoided different types of tablets such as melts, chewable and oro-dispersible tablets

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Week 5: Target population specific formulation

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Week 5: Target population specific formulation

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- Liquid medicines are usually recommended for infants and younger children so the ability to mask unpleasant taste with sweeteners and flavours is crucial.

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Diphenhydramine & Levomenthol

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Children night cough

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- colouring agents
- flavoring agents
- sweetning agents
- Stablizers
- preservatives
- Viscosity enhancers
- dilutents
- vehicles e.g purified water

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-The age at which children take tablets or capsules is a factor of importance to their safety so that inadvertent inhalation and choking are avoided different types of tablets such as melts, chewable and oro-dispersible tablets.

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-The age at which children take tablets or capsules is a factor of importance to their safety so that inadvertent inhalation and choking are avoided different types of tablets such as melts, chewable and oro-dispersible tablets.

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-Liquid medicines are usually recommended for infants and younger children so the ability to mask unpleasant taste with sweeteners and flavours is crucial                                                                                                                              

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-Liquid medicines are usually recommended for infants and younger children so the ability to mask unpleasant taste with sweeteners and flavours is crucial                                                                                                                              

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Made from glucose and fructose together

1)    Conc in medicine 1.707g / 5 ml

2) solid at standard temp & pressure

3) very soluble in water

4) The polar water molecules attract the negative and positive areas on the polar sucrose molecules

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1)      Conc in medicine 0.75ml per 5Ml

2)      Liquid at room temp

3)      Completely miscible in water as it forms hydrogen bonds with water molecules

4)    The OH groups can form hydrogen bonding with water

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-Citric acid monohydrate

-Sodium benzoate (E211)

-Cough syrup 513277 flavour (containing anise oil, liquorice, propylene glycol, ethanol (alcohol)

-Black treacle

-Liquid glucose

-purified water

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Glycerol & Sucrose

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- glass bottles are temperature  resistant so it extend the lifetime and non reactive to chemicals so there will be no leakage of matter into the liquid.                                                                                                  -Some plastic containers start to interact with the medicine but Glass can be easily sterilized  and since its resistant  to high temp it can be boiled to kill any harmful bacteria

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- glass bottles are temperature  resistant so it extend the lifetime and non reactive to chemicals so there will be no leakage of matter into the liquid.                                                                                                  -Some plastic containers start to interact with the medicine but Glass can be easily sterilized  and since its resistant  to high temp it can be boiled to kill any harmful bacteria

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 -child lock safe lid to prevent overdose of drug on the child since its sweet, they might want to keep having it when at inappropriate times                                                                                     

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 -child lock safe lid to prevent overdose of drug on the child since its sweet, they might want to keep having it when at inappropriate times                                                                                     

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external packaging

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7. external packaging

-  cautions and dosage table

- description of uses of medicine

- possible side effects

- clear diagram at the front to show where the medicine works for

e.g throat

- box claims to relieve ' dry, & sticky coughs and sore throats' - which relates to the properties of glycerol

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- Amber glass to block photooxidation from sunlight as some chemicals can start to be affected                                                                                                                                                                            

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- Amber glass to block photooxidation from sunlight as some chemicals can start to be affected                                                                                                                                                                            

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week5: target population specific formulation

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week5: target population specific formulation

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This Padlet is about the Benylin Dry & Tickly cough syrup