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The term organic comes from Greek ο1γανον, organon, instrument, and has roots going back to Aristotle.

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Chemistry was just known as inorganic, Paracelsus was an important alchemist, iatrochemist and medical practitioner.

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Paracelsus stated that living bodies are composed by mercury, sulfur, and salt.

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Sennert explained the laboratory processes in terms of synkrisis (aggregation or combination) and diakrisis (differentiation or separation).

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Oswald Croll, a medical doctor from the University of Marburg and Johannes Hartmann, professor publicus chymiatriae in Marburg restated Paracelsus’ doctrines.

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Pierre Gassendi establishes that atoms are the smallest parts and when combined form molecules.

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Georges- Louis Leclerc used the term "organic molecules" which were supposed to be taken up from the organic matter in food to serve as nourishment and in the development and reproduction

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Charles de Bonnet in Geneva once again used organic molecules in his hypothesis of the organic body, where he held that pre-existing "germs" in life were responsible for reproduction with the help of male semen.

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Bergman classified organic and inorganic bodies into 4 different characteristics.

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Lavoisier determined the composition of water by synthesis and decomposition.

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Carl Wilhelm Scheele isolated glycerol from the decomposition of olive oil, by boiling with PbO

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Lavoisier described organic compounds containing C, H, O and noted that N may also be present

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-Friedrich Gren wrote about organic bodies and the changes in their mixtures. He also proposed the name "fermentation".
-Lavoisier reported his combustion analysis and determined that organic bodies were composed of carbon and hydrogen.

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Berzelius made substantial experimental innovations in combustion analysis; he determined that the major constituent of living bodies was carbon along with other elements. He defined them as C, H, O, N, S, P, K, Na, Ca, Mg, Si and Fe and added Cl and F.

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An assistant of Vauquelin, saponified fats to glycerol, and separated the fatty acids.

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Liebig and Gay-Lussac, analyzed the elemental composition of silver fulminate.

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Wöhler analyzed silver cyanate and formulated it as the salt of cyanic acid. Liebig thought that Wöhler's analysis was wrong, but then he could confirm he was right and became long-life friends.

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Wöhler's sensational synthesis was carried out by treating silver oxycyanate with an aqueous solution of ammonium chloride, or lead oxycyanate with "liquid ammonia". This synthesis of urea from ammonium cyanate caused a paradigm shift. He make it seem like the artificial urea he made was actual urea from urine. Showing that an organic substance could be made out of inorganic bodies.

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Liebig could observe that HNCO and NH3 could be both prepared without the intervention of an organic compound, so Wöhler's synthesis was absolute

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Berzelius made the concept of "isomerism"

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Liebig and Wöhler stated “The philosophy of chemistry will draw the conclusion from this work that the production of all organic materials in our laboratories must be considered not only likely but certain,in as much as they no longer belong to the organism. Sugar, salicin, and morphine will be produced artificially.Of course,we do not yet know the ways to reach this goal, because we do not know the precursors from which these compounds are generated, but we shall get to know them”

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Pierre Eugène Marcellin Berthelot achieved the synthesis of new organic compounds that were before not known to exist in nature by combining natural carboxylic acids with glycerol.