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tremor…shaking, shiver
rigidity...stiffness
trunk...torso

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AFFiRis is a biopharmaceutical company located in Vienna . Its aim is to improve the lives of patients suffering from neurodegenerative diseases by providing disease-modifying specific active immunotherapies (SAIT) based on the company-own AFFITOME technology.

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Studies have shown that the symptoms of Parkinson’s usually appear when 50 percent or more of the dopamine neurons in the midbrain have been lost.

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Parkinson’s disease is a common neurodegenerative disease which mainly affects the motor system

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Parkinson’s disease is a common neurodegenerative disease which mainly affects the motor system

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It progresses slowly as small clusters of dopaminergic neurons in the midbrain die. The loss of these neurons results in reduction of dopamine, a chemical responsible for transmitting messages to parts of the brain that coordinate muscle movement. Studies have shown that the symptoms of Parkinson’s usually appear when 50 percent or more of the dopamine neurons in the midbrain have been lost.

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National Institutes of Health, "Parkinson Disease",
https://rarediseases.info.nih.gov/diseases/10251/parkinson-disease [21.03.2021]

medlineplus, "SNCA gene", https://medlineplus.gov/genetics/gene/snca/#conditions [24.03.2021]

Parkinson Fundation, "Environmental Factors", https://www.parkinson.org/Understanding-Parkinsons/Causes/Environmental-Factors#:~:text=Scientists%20are%20working%20to%20better,environment%20can%20be%20quite%20complex. [21.03.2021]

National Institute of Environmental Health Sciences, "Parkinson's Disease and Environmental Factors", https://www.niehs.nih.gov/health/assets/docs_p_z/the_role_of_the_environment_in_parkinsons_disease_508.pdf [21.03.2021]

NHS, "Treatment - Parkinson Disease", https://www.nhs.uk/conditions/parkinsons-disease/treatment/ [21.03.2021]
https://parkinsonsdisease.net/medications [21.03.2021]

Parkinsondisease, "Medications Used to Treat Parkinson's", https://parkinsonsdisease.net/medications [21.03.2021]

AFFiris, "Our Approch", https://affiris.com/ [24.03.2021]

Images

National Institute of Environmental Health Sciences, "Parkinson's Disease and Environmental Factors", https://www.niehs.nih.gov/health/assets/docs_p_z/the_role_of_the_environment_in_parkinsons_disease_508.pdf [21.03.2021]

Parkinson Fundation, "Environmental Factors", https://www.parkinson.org/Understanding-Parkinsons/Causes/Environmental-Factors[ 21.03.2021]

Drjockers, https://drjockers.com/wp-content/uploads/2012/07/parkinson-brain5431.jpg [24.03.2021]

Frepik, "Parkinson's Disease symptoms", https://de.freepik.com/vektoren-kostenlos/parkinson-krankheit-symptome-infografik_9819299.htm [21.03.2021]

Careageceneter, https://careagecenter.com/parkinson-disease/ [21.03.2021]

Parkinsondisease, "Medications Used to Treat Parkinson's", https://parkinsonsdisease.net/medications [21.03.2021]

AFFiris, https://affiris.com/ [24.03.2021]

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SAIT = Specific Active Immunotherapy

It is a  treatment that harnesses the power of the immune system

rogue proteins that are involved with the development and progression of neurodegenerative diseases are targeted

AFFITOME Technology

creation of proteins with specific binding properties possible

these are ideally suited for the production of vaccines against diseases caused by dangerous endogenous proteins

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Potential benefits from AFFITOME technology & SAIT 

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Potential benefits from AFFITOME technology & SAIT 

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Quarterly/twice-yearly dosing

one injection required per dose

physician adminstration enhances adherence

target-specific antibody response

long-lasting immune response

well-tolerated

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levodopa

absortion of Levodopa by the nerve cells

transformation of levodopa into dopamine

dopamine agonists

substitute for dopamine

monoamine oxidase-B inhibitors

they block the effects of an enzyme or brain substance that breaks down dopamine

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supportive therapies, such as physiotherapy

medication

surgery (for some people)

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tremors

rigidity of limbs and trunk

difficulties with balance, speech, and coordination

Dyskinesia: involuntary, erratic writhing movements of the face, arms, legs or trunk.

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poor sense of smell

constipation

depression

cognitive

impairment

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Brain injury that results in alteration in level of consciousness — has been associated with an increased risk of developing Parkinson Disease years after the injury.

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Herbicides (eg paraquat) have been linked to cause Parkinson Disease.

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Disorder of the basal ganglia causes the death of dopamine generating cells
Parkinson disease occurs when the nerve cells in the brain that make dopamine are slowly distroyed. Without dopamine, the nerve cells in the brainregion substantia nigrra cannot properly send messeges. This leads to a progressiv loss of muscle function.

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Pointmutation on SNCA-Gen which codes for a protein called alpha-synuclein

misfolded or excess alpha-synuclein proteins can cluster together to lewy bodies

lewy bodies can disrupt the regulation of dopamine, which allows dopamine to accumulate to toxic levels and eventually kill neurons