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Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

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Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

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Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

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Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

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A 20 años de la secuenciación del genoma humano, número especial de Science

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A 20 años de la secuenciación del genoma humano, número especial de Science

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Abstract

Background: Mexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. However, the number of confirmed cases and RT-PCR tests per million population are lower than for other countries, which leads to uncertainty about the actual extent of the pandemic. In Mexico City, health care workers represent an important fraction of individuals with SARS-CoV-2 infection. This work aims to estimate the frequency of antibodies to SARS-CoV-2 in health care workers at a non-COVID hospital, as well as identify factors associated with SARS-CoV-2 infection in this population. Methods: We conducted a serological survey in a large non-COVID teaching hospital in Mexico City. The study population included all the personnel that works, in any capacity, in the hospital. From this population we selected a representative sample of 300 individuals. Blood samples were collected and questionnaires were applied between August 10th and September 9th, 2020. Results: ELISA results indicate a serological prevalence to SARS-CoV-2 infection of 13.0%. Working in the janitorial and security groups, having an educational level below a university degree, and living with larger numbers of people, were also identified as sociodemographic factors that increase the risk of having SARS-CoV-2 infection. Conclusions: Even though the rate from the official number of confirmed cases in Mexico City is substantially smaller than the seropositive rate identified in this work, even in health care workers there is still a majority of individuals that are seronegative, and thus the risk of continued epidemic waves and mortality remains high.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

The authors received non-financial support (a donation of serological tests) for the conduct of this study. No other funding from a third party was received.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Ethics and Research Committees of the Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra"

All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Data Availability

Data referred to in the mansucript can be made available by contacting the corresponding author.

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Serological prevalence of SARS-CoV-2 infection and associated factors in health care workers in a "non-COVID" hospital in Mexico City

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Background: Mexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. However, the number of confirmed cases and RT-PCR tests per million population are lower than for other countries, which leads to uncertainty about the actual extent of the pandemic.

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