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Close contact
Defects in mucosal membrane
Enters through cutaneous nerve fibers

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HSV-1 is commonly associated with outbreaks of the face, cold sores/fever blisters.

It is wide spread in humans with broad host ranges.

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Microscopy
Antigen Detection
DNA detection
Viral isolation
Serology

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Cytopathic effect of HSV in a cell culture

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Transmission can be reduced by: safe sex, antiviral therapy, and good hygiene

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Aciclovir, Valaciclovir, Famiciclovir

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•Skin vesicles & ulcers

•Small 2-4mm vesicles

•Most are asymptomatic/unrecognized as skin fissures

•Fever blisters or cold sore are the most common

•Lesions may occur on the nose, chin, cheek, or orally

•Burning, tingling, itching, or pain occur 3-6 hours before the development of lesions