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Squilliam Fancyson is the Vacuole because he won the award for keeping Bikini Bottom clean by collecting the most trash.
(Clipart)

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(Spongebob.wikia)

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The dumpsters behind Krusty Krab are the lysosomes because that's where all the trash from Bikini Bottom gets picked up.
(cell world hollllaaaa)

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(Spongebob.wikia)

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The Roads of Bikini Bottom is the cytoskeleton because they help move people around the Bikini Bottom.
(BSCB)

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Sandy Cheeks's Residence is the centriole because it divides Sandy from the rest of Bikini Bottom
(slideplayer)

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(Spongebob.wikia)

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The fence surrounding the Bikini Bottom is the cell membrane because it acts as a boundary and it lets people in and out of Bikini Bottom.
(fact file)

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(Spongebob.wikia)

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(Krabby.Kronicle)

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(Spongebob.wikia)

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The water is the cytoplasm because it the liquid that fills all the surroundings in the Bikini Bottom.
(buzzle)

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(sbmania)

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(Spongebob.wikia)

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The Krusty Krab is obviously the nucleus because the Krusty Krab is the place where everyone goes, just like the nucleus.
(kids biology)

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The Krabby Patty is the mitochondria because it's what fuels all the inhabitants of the Bikini Bottom.
(blogspot)

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(Spongebob.wikia)

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The window in the Krusty Krab is the ER because it where all the food thats been prepared gets sent out to the customers.
(qph)

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Norton, the mailman, is the golgi apparatus because he is constantly receiving and sending out packages.
(futura sciences)

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(cdn)

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(Spongebob.wikia)

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Spongebob is the ribosomes because he makes the krabby patties that fuels Bikini Bottom and keeps it running.
(cdn)