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Discrimination happened to Mutants due to something they couldn't control- a gene mutation.

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"Instead of dreaming  up a clever way that they got their superpowers, I figured I'll just let them be born that way- they're mutants," Stan Lee said.

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"...it is impossible is impossible to understand organismal and cellular biology or evolution... without first reckoning with the concept of the gene," (Mukherjee Pg.11)."