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the middle Age can be regarded as beginning with the plague of 542 . The plague of 542 is the Justinian Plague which is the popular name for the Bubonic plague and it is said that it killed about 5000 people in the Byzantine capital of Constantinople . According to the historians rats where carrying  the plague infested fleas which likely brought the disease over. there was not a know cure for the disease.

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Leprosy was discovered in 1874 originated either in Africa or Asia but it had reached Europe . Leprosy is an infectious disease that is causes severe , disfiguring skin sores and nerve damage in the arms ,legs ,and skin areas . the cure for leprosy now is a combination of antibiotics

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the origin of smallpox is unknown but it was introduced to Europe sometime between the 5th and 7th centuries and was frequently epidemic during the middle ages . soon by the time the  contagious disease, caused by the variola virus, had spread all across Africa and Asia as well, prompting some cultures to worship special smallpox deities. In the Old World, the most common form of smallpox killed perhaps 30 percent of its victims while blinding and disfiguring many others and many ways they tried to cure smallpox included many herbal remedies, and cold treatment and special cloths . Today there is still no treatment for smallpox that has been tested in people who are sick with the disease and proven effective

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in the middle Ages , Scrofula, a disease affecting cervical lymph nodes, was described as a new clinical form of TB the illness was known in England and France as "Kings evil" and it was widely believed that  people could heal after a royal touch . Today The most common treatment for active TB is isoniazid INH in combination with three other drugs—rifampin, pyrazinamide and ethambutol.

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The communities of large populations lived overcrowded cities in Unsanitary conditions during the Middle Ages and because of close body contact was frequent and the scabies could be passed around faster and the way it was treated back then was with a sulfur-bearing ointment called by the medical eponym of Wilkinson's ointment and today it is treated with a permethrin cream and malathion lotion

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Erysipelas has been traced back to the Middle Ages, where it was referred to as St. Anthony's fire, named after the Christian saint to whom those afflicted would appeal for healing.

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in the middle ages anthrax was found in meat from slaughtered murrain-infected cattle was sold in villages in England shortly before the first big outbreak.

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sweating sickness is a illness began with  headache giddiness, and severe prostration. After one to three hours, violent, drenching sweat  came on, accompanied by severe headache, delirium, and rapid pulse.  sweating sickness doesn't have a cure yet