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Deadpool's primary power is an accelerated healing factor, depicted by various writers at differing levels of efficiency. The speed of his healing factor depends on the severity of the wound and Deadpool's mental state. It works most efficiently when he is awake, alert, and in good spirits.[78] Deadpool's accelerated healing factor is strong enough that he has survived complete incineration and decapitation more than once.

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Deadpool's brain cells are similarly affected, with dying neurons being rejuvenated at a super accelerated rate. This allows Deadpool to recover from any head wounds, and it renders him nearly invulnerable to psychic and telepathic powers,[82][83] although this ability is inconsistent

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Deadpool (Wade Winston Wilson) is a fictional character appearing in American comic books published by Marvel Comics.

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Initially Deadpool was depicted as a supervillain when he made his first appearance in The New Mutants and later in issues of X-Force, but later evolved into his more recognizable antiheroic persona. Deadpool, whose real name is Wade Wilson, is a disfigured and deeply disturbed mercenary and assassin with the superhuman ability of an accelerated healing factor and physical prowess.

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After the events of Deadpool Kills the Marvel Universe, Deadpool has killed many versions of Marvel superheroes and villains across the multiverse to no effect and comes to a conclusion that infinite alternate versions of the heroes and villains he killed exist.[volume & issue needed] In the series, Deadpool hires a team of scientists to help him get rid of all Marvel characters.

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On April 4, 2013, Cullen Bunn revealed that, after the events of Deadpool Killustrated, the next and last part of the "Deadpool Killology" will be Deadpool Kills Deadpool and that the murderous, nihilistic Deadpool that appeared in Deadpool Kills the Marvel Universe and Killustrated is called "Dreadpool" and, in the series, he is hunting down all versions of Deadpool while "our" Deadpool, the light-hearted Merc With A Mouth, is hunting down Dreadpool.

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In the storyline Deadpool Kills the Marvel Universe, the X-Men send Deadpool to a mental hospital for therapy. The doctor treating him is actually Psycho-Man in disguise, who attempts to torture and brainwash Deadpool into becoming his personal minion. The procedure fails, but leaves Deadpool even more mentally unhinged, erasing the "serious" and "Screwball" voices in his head and replacing them with a voice that only wants destruction.