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- The skin is a site for the presentation of antigens to T cells. It's involvement in immune response via mucosal surfaces classifies it to be a lymphoid associated organ.

- it functions as a peripheral lymphoid tissue.

- The skin has APC's and memory cells that reside within it. As a result, when an antigen enters into the skin initially, it is engulfed by APCS and subsequently presented to memory cells.

- On second encounter, the presence of these memory cells  trigger an inflammatory response in a phase known as the challenge phase ( the two phases are represented in figure below)

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Langerhans cells: sentinels of skin associated lymphoid tissue. - PubMed - NCBI

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J Invest Dermatol. 1980 Jul;75(1):78-82. Research Support, U.S. Gov't, P.H.S.

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Egawa, G. and Kabashima, K. (2011). Skin as a Peripheral Lymphoid Organ: Revisiting the Concept of Skin-Associated Lymphoid Tissues. Journal of Investigative Dermatology, 131(11), pp.2178-2185.

Toews, G., Bergstresser, P. and Streilein, J. (1980). Langerhans Cells: Sentinels of Skin Associated Lymphoid Tissue. Journal of Investigative Dermatology, 75(1), pp.78-82.

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Streilein, J.W., 1989. Skin-associated lymphoid tissue. Immunology series, 46, pp.73-96.

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WileyPLUS textbook