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Minion is Megamind's best friend, sidekick and caretaker. He is also Megamind's true only reminder of his long lost home planet: a pet "fish" that was carried across the galaxy in Megamind's space pod. Megamind built an ape-like robot suit to house his faithful Minion, who now serves as Megamind's loyal sidekick.

http://mega-mind.wikia.com/wiki/Minion

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Megamind improbably chooses Hal to become his new rival, making the newly christened "Tighten" Megamind's ultimate nemesis. Hal soon finds that being bad is much more fun which leads to Metro City's new superhero to slowly but surely become the most dangerous super villain of all until Megamind took back Metro Man's powers from him.

http://mega-mind.wikia.com/wiki/Hal_Stewart

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Metro Man, another alien refugee from the Glaupunk Quadrant, is the adopted son of Lord and Lady Scott, a retired superhero and Megamind's initial arch-nemesis of good (later to be 'replaced' by Tighten). He, like Megamind and Minion is the last member of his species.

http://mega-mind.wikia.com/wiki/Metro_Man

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Roxanne Ritchi, usually referred to as Roxanne or Roxie, is a smart, practical journalist,  Metro Man's supposed girlfriend, and Megamind's former hostage in nearly every one of his battles against Metro Man.

http://mega-mind.wikia.com/wiki/Roxanne_Ritchi

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Megamind: Funny. I guess destiny isn't the path chosen for us, but the path we chose for ourselves.

~
Metro Man: Buddy, there's a yin for every yang. If there's bad, good will rise up against it!
~

Tighten: You're so pathetic! No matter what side you're on, you're always the loser!

Megamind: There's a benefit to losing: You get to learn from your mistakes.

http://www.imdb.com/title/tt1001526/quotes

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-The film's plot was based on the premise: "What if Lex Luthor defeated Superman?"
-Metro City is located in Michigan. This can be clearly seen in a shot where Megamind's satellite is in orbit around the earth.

http://www.imdb.com/title/tt1001526/trivia?ref_=tt_trv_trv

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The main characters in the movie are Metro Man, Minion, Megamind, Roxanne Ritchie, and Tighten.
(From left to right)

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Minion, seen below, is Megamind's sidekick who was sent with him to Earth when Megamind was a couple days old and their planet, along with Metro Man's planet, was being sucked into a black hole. He helps out Megamind with his plans and is his closet companion. At times, he provides comic relief for the story.

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The main character of this movie is, as the title says, Megamind (shown in the picture below). He is a genius, who has been inventing things ever since he came to Earth. Although he is supposedly a villain, he's pretty clumsy and kind to those he's close to.

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"Megamind" is the most brilliant super–villain the world has ever known... and the least successful. Over the years, he has tried to conquer Metro City in every imaginable way – Each attempt, a colossal failure thanks to the caped superhero known as "Metro Man," until the day Megamind actually defeats him in the throes of one of his botched evil plans. Suddenly, the fate of Metro City is threatened when a new villain arrives and chaos runs rampant, leaving everyone to wonder: Can the world's biggest "mind" actually be the one to save the day?

http://www.filmjabber.com/movie-synopsis/oobermind.html