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Nervous tissue is found in the brain and spinal cord, and it is the least radiosensitive tissue in the body.

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The radiosensitivity of reproductive cells differs between male and females and depends on the state of development of the cell. Overall, female reproductive cells are more radiosensitive, and immature reproductive cells are more radiosensitive than mature cells.

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Muscle cells are some of the least radiosensitive cells in the body because they are highly specialized and do not divide.

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Epithelial tissue does not have blood vessels and therefore is constantly sloughing off and regenerating, which makes it fairly radiosenstive.

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- Immature, therefore more radiosensitive (Tenant 4)
- Maximum sensitivity is 8-15 weeks after gestation
- Lower level of elevated risk until week 25
- Only do medical imaging procedures if vital
Dose:
- 0.1-Sv fetal EqD is known to increase the chance of intellectual disability by as much as 4%

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Radiosensitivity is a function of the metabolic state of the cell receiving the exposure.
This is true for all types of cells in the human body.

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The radiosensitivity of cells is directly related to their metabolism.

higher cell metabolism = more radiosensitivity

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The radiosensitivity of cells is directly proportional to their reproductive activity.

greater reproductive activity = more radiosensitivity

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The radiosensitivity of cells is inversely proportional to their degree of differentiation (ability to perform special functions)

more specialized functions = less radiosensitivity

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Blood cells are the some of the most radiosensitive cells in the body. These cells are constantly regenerating and cells like erythrocytes carry oxygen, which increase the effects of ionizing radiation.

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- Most radiosensitive blood cell
- Live for only 24 hours (Tenant 2, 4)
Dose:
- 0.25 Gy can depress the number of cells in circulating blood. Recovery occurs shortly after irradiation.
- 0.5 to 1 Gy can cause the cell count to decrease to zero within days. Recovery takes several months.
- The body becomes highly susceptible to antigens.

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Dose:
- 0.5 Gy reduces number of cells in circulating blood
- 2 to 5 Gy reduces number of cells by 10% or less within several weeks. Recovery takes several months.

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- Lifespan of 30 days (Tenant 2, 4)
Dose:
- 0.5 Gy lessens amount of platelets in circulating blood
- 1 to 10 Gy significantly depletes the number of platelets. Recovery begins as early as 2 months after irradiation.

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Mature:
- do not divide therefore are relatively insensitive to ionizing radiation (Tenant 2, 4)
Immature:
- extremely radiosensitve because they divide rapidly (Tenant 2, 4)
Dose:
- 0.1 Gy could depress the population or cause genetic mutations
- 2 Gy can cause sterility for up to 12 months
- 5 or 6 Gy can cause permanent sterility

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Mature:
- little radiosensitivity (Tenant 2, 4)
Immature:
- very radiosensitive (Tenant 2, 4)
Dose:
- As low as 0.1 Gy could cause menstrual irregularities
- 2 Gy can cause temporary sterilization
- 5 Gy usually causes permanent sterility in mature women
- Up to 20 Gy can be tolerated if received over several weeks

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The radiosensitivity of cells is inversely proportional to their age.

more cell maturity = less radiosensitivity

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- Highly specialized, therefore less radiosensitive (Tenant 3)
- Mature, therefore less radiosensitive (Tenant 4)
Dose:
- Takes around 50 Gy to kill nerve tissues
Damage:
- If the nucleus is damaged, the cell may still be able to function but is impaired.
- If the nucleus is destroyed, the cell dies and is not restored.
- Damage to dendrites and axon is also possible and would cause disruption of communication to the body.

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- Relatively insensitive due to being highly specialized (Tenant 3)
- Do not divide, so less radiosensitive (Tenant 1)

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- Highly radiosensitive because it is constantly regenerated through the process of mitosis (Tenant 1, 2)
- Erythema can appear between 24-48 hours after an absorbed dose of 2 Gy