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1918 to 1919- 50 millions of deaths

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caused over 100,000 deaths in the United States, out of a global total in excess of one million. Then,

“Hong Kong Flu is Un-American. Catch Something Made in the USA.” was on the rise

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it is ongoing-The disease doesn't 'require' a self isolation type of procedure like covid-19, for example, however it is easily spread - by the end of 2018, 32 million deaths were caused.

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2002-2003
800 deaths from 8,000 cases

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2009-2010
it is an H1N1 virus in the category of the Spanish flu that infected hundreds of millions worldwide, only it had less impact
infected millions worldwide but did not have such impact as the others

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2013. Through parts of West Africa between 2014 and 2016 killed 11,300 people.

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2015
no region has proved itself immune to penetration from disease
858 lives lost from 2,494 reported infections

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started in 2020 and almost 2 million deaths globally.