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Breakthrough Treatment for Postpartum Depression

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Cornett, E. M., Rando, L., Labbé, A. M., Perkins, W., Kaye, A. M., Kaye, A. D., Viswanath, O., & Urits, I. (2021). Brexanolone to Treat Postpartum Depression in Adult Women. Psychopharmacology bulletin, 51(2), 115–130.

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March 16, 2021

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In 2019, the FDA approved an intravenous infusion treatment designed to treat postpartum depression specifically. This novel therapy, administered around the clock for 60 hours, uses a neurosteroid to control the brain’s response to stress. This treatment design is groundbreaking as it targets the signaling thought to be deficient in hormone-sensitive postpartum depression. Additionally, this treatment appears to show benefits very quickly, while traditional anti-depressants typically take two to four weeks to have a significant effect (Clevland Clinic, 2022).

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https://www.youtube.com/live/kxxP_bfk4YA?si=h85oYX9kaJJXjrGh

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Effects are almost immediate

One time treatment

Little side effects

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It can cause excessive sedation, dry mouth, and loss of consciousness.

Long treatment duration causes a need for child care.

Unclear how long effects will last.

Limited access due to the need to be monitored inpatient for 60 hours while the infusion is given.

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I think that this is a huge innovation because it could really help patients with PPD get the relief they need in a short amount of time. PPD is something that needs to be treated fast so that the mother does not hurt herself or the baby. Previous treatments, like a pill, take 4-6 weeks to work, and this could be the difference between a mother taking her life or her babies and a mother thriving as a new mom.

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1. Restorative

2. Consistency

3. Futuristic

4. Relator

5. Deliberative

My strengths will help the team in several ways. Consistency is imperative in a team setting, and I am a strategic and unconventional thinker. I am also able to build strong relationships and adapt to any problem that may arise.

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Cleveland Clinic. (2022, February 16). Cleveland Clinic unveils top 10 medical innovations for 2022. https://newsroom.clevelandclinic.org/2022/02/16/cleveland-clinic-unveils-top-10-medical-innovations-for-2022

Commissioner, O. of the. (2019, March 19). FDA approves first treatment for post-partum depression. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-post-partum-depression

Cornett, E. M., Rando, L., Labbé, A. M., Perkins, W., Kaye, A. M., Kaye, A. D., Viswanath, O., & Urits, I. (2021). Brexanolone to Treat Postpartum Depression in Adult Women. Psychopharmacology bulletin, 51(2), 115–130.

Treat Postpartum Depression. Treat Postpartum Depression | ZULRESSO® (brexanolone) CIV. (n.d.). https://www.zulresso.com/

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Angelica- analytical

Carter- communication

Fernando- focus

Isabella- includer

Pablo- positivity

I chose Angelica because it is important to have someone on the team who can think strategically.

I chose Carter because communication is imperative for a team to work together to reach a common goal.

I chose Fernando because it is good to have people that can follow and take directions from others on the team.

I chose Isabella because she will help ensure everyone is included in the discussions and accept everyone.

I chose Pablo because group work and being tedious bring people into a bad mood if it isn't going well. he could lighten the mood and help everyone stay positive.