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Teraski Institute For Biomedical Innovation
Authors:  Reihaneh Haghniaz, Ankit Gangrade, Hossein Montazerian, Fahimeh Zarei, Menekse Ermis, Zijie Li, Yuxuan Du, Safoora Khosravi, Natan Roberto de Barros, Kalpana Mandal, Ahmad Rashad, Fatemeh Zehtabi, Jinghang Li, Mehmet R. Dokmeci, Han-Jun Kim, Ali Khademhosseini, Yangzhi Zhu

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June 4, 2023

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Very intelligent researchers at Terasaki Institute for Biomedical Innovation (TIBI) have created an implantable sponge with the ability to monitor and control for hemorrhaging. The researchers developed the device to consist of three layers. The top and bottom layers are made of silver nanowires which provide antibacterial properties, and the middle spongy layer acts as a sensor that detects for bleeding (Hastings, 2023). The TIBI researchers state, "developing more advanced signal processing techniques and/or integrating other biosensors could enhance the device's specificity, accuracy, and practicability (Haghniaz et al., 2023)."

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https://www.medgadget.com/2023/08/implantable-sponge-for-hemorrhage-monitoring-and-control.html

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Researchers at the Terasaki Institute for Biomedical Innovation in California have developed an implantable sponge that can monitor for signs of a hemorrhage, and then help to control bleeding once it has occurred. The researchers used silk fibroin, a protein produced by the Bombyx mori silkworm, to create the sponge, and took advantage of its biodegradation and anti-inflammatory properties to create a porous and highly absorbent shape-memory sponge. The sponge also contains two layers of silver nanowires above and below the sponge layer which deliver anti-bacterial action and serve as a hemorrhage monitoring system. The wires act as capacitance sensors, whereby the capacitance increases as the sponge absorbs blood.

There are many different approaches to stem bleeding, including bandages and tourniquets, but many of these are suitable only for external wounds that are amenable to compression. For irregular wounds or internal wounds, such solutions may not work so easily. One option is the shape-memory sponge. When applied to a wound it absorbs blood, helping to promote coagulation, and also applies pressure to the underlying wound as it swells with blood.

However, existing sponges for this application, such as those made using collagen or gelatin, are purely mechanical and cannot alert clinicians to the emergence of a hemorrhage. However, they can help to stop the bleeding and usually incorporate biodegradable materials so that they may not require removal through a second surgical procedure if implanted internally. These researchers wished to take this concept one step further and incorporate a system that would alert them to the presence of a hemorrhage.

Their sponge contains silver nanowires that form capacitive sensors that produce a measurable electric signal when the sponge becomes filled with blood. Moreover, the silver in the wires also provides an anti-microbial effect to help ward off infections. The researchers have also been able to tune the biodegradation and mechanical properties of the sponge to suit different clinical scenarios.

"This multifunctional device offers many attractive features for hemorrhage control and wound monitoring and is highly adaptable for different types of wounds and tissues," said Ali Khademhossein, one of the lead scientists that developed the new sponge. "And the hemorrhage monitoring feature also opens up several possibilities for integrative biosensing and additional therapeutics."

Study in journal Advanced Science: An All‐In‐One Transient Theranostic Platform for Intelligent Management of Hemorrhage

Via: Terasaki Institute for Biomedical Innovation

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Implantable Sponge for Hemorrhage Monitoring and Control |

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Researchers at the Terasaki Institute for Biomedical Innovation in California have developed an implantable sponge that can monitor for signs of a

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- can be applied internally
- made with biodegradable material and won't require 2nd procedure to be removed
- has the ability to apply pressure as it absorbs blood
- prevents bacterial infections

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- not realistic for larger wounds
- unable to accurately detect rapid or emergent blood loss

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This small, but mighty device can definitely be life-saving! From working in an ER, I know that hemorrhaging is one of the fastest causes of death, especially in trauma patients. It can also be prevented when detected early. With this implantable sponge, medical professionals can act quickly to stop the bleed and reduce the risk of mortality (Haghniaz et al., 2023). I also believe that this device can lead to further medical advances and provide rapid detection of other preventable causes of death.

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1. Consistency
2. Harmony
3. Futuristic
4. Developer
5. Discipline

All of my strengths relate to relationship building and strategic thinking. With my top 2 strengths being consistency and harmony, I am able to "keep the peace" of the team and treat everyone equally/fairly. I usually keep a futuristic mindset and plan my tasks accordingly.

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1. Carter (communication)- Communication is a very important part of being on a team. Carter would be a great entertainer and presenter of the information.

2. Faith (futuristic)- I also have this as one of my strengths. Another person with a futuristic mindset could offer another perspective on the advancement of the innovation.

3. Sheila (strategic)- Sheila would be a great asset in making quick, but solid decisions when the unexpected arises.

4. Angelica (analytical)- Angelica could challenge the team by asking all of the hard questions. She would be good with numerical data and ensure that we are being thorough.

5. Louis (learner)- With a medical innovation, it is important that we are continuously improving the device. Louis could keep us up to date with new technology.

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Haghniaz, R., Gangrade, A., Montazerian, H., Zarei, F., Ermis, M., Li, Z., Du, Y., Khosravi, S., de Barros, N. R., Mandal, K., Rashad, A., Zehtabi, F., Li, J., Dokmeci, M. R., Kim, H., Khademhosseini, A., & Zhu, Y. (2023). An all‐in‐one transient theranostic platform for intelligent management of hemorrhage. Advanced Science, 10(24). https://doi.org/10.1002/advs.202301406

Hastings, C. (2023, August 2). Implantable sponge for hemorrhage monitoring and control |. Medgadget. https://www.medgadget.com/2023/08/implantable-sponge-for-hemorrhage-monitoring-and-control.html