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The damage to Will's mental health due to his return to the FBI is an example of the unhealable wound. When he killed Garrett Jacob Hobbs, is psyche was injured so badly that is caused him to begin hallucinating. His untreated encephalitis also spurred this. This would is very painful and pushed Will to very desperate measures.

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Abigail Hobbs is portrayed as the innocent. She is very kind, naïve, and vulnerable as a result of her father's murders. She is shown as needing help and guidance from both Hannibal and Will. Although she was horrified of her father's actions, she helped him to save her life. She inspires protective feelings in most people she meets, including Will and Hannibal.

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Will Graham is both the protagonist and anti-hero in Hannibal. He shows courage and kindness towards those around him. However, he also does many bad things in the name of a good reason. He is manipulative, callous, and impulsive.

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Will Graham's entire professional world comes to an abrupt end when Jack Crawford decides to charge him with murdering Abigail Hobbs. Hannibal pretends to be in grief over Abigail's death at his therapist's office. She advises Hannibal to avoid Will throughout and after his murder case, since rehabilitation attempts may be harmful to Dr. Lecter given his ties to Abigail. Hannibal regrets not being able to save Will or Abigail. Will begins to figure together that Hannibal was always at his side while he was at the copycat crime scenes. Will discovers at the Hobbs residence that it was Hannibal who killed all these people, not him. Will draws a gun on him, now that he's realized he's in the presence of the Chesapeake Ripper. At the last second, Jack Crawford enters and shoots Will in the shoulder, assuring Hannibal's safety from Will's "murderous" ways. After Will recovers completely, he is sent to a maximum-security jail for trial, and Hannibal pays him a visit. In his eyes, he has won.

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Will brings Abigail to the home where her father murdered all of his victims. Will discovers that Abigail was the bait used by her father to draw in all the women he murdered. Will's picture of Abigail is tainted by this stunning news, which pushes him into a psychotic episode. Will struggles with reality and delusion until he wakes up on a flight, back in Virginia, with Abigail missing. Hannibal is waiting for Abigail in her home when she returns, and he informs her that Jack is aware of her involvement in her father's murders and apologizes for failing to protect her. Abigail questions Hannibal about why he called her father the day her father was shot by Graham, and he responds that he was curious what would happen. He admits to being the Chesapeake ripper and informs Abigail that he has killed many more people than her father. Abigail, terrified, asks whether Hannibal intends to murder her as well. Will then asks for Jack and Hannibal to help him find Abigail, and when they go back to her home, they "find" Abigail's blood and her ear in the kitchen, where her father was going to kill her.

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The BAU team ties Abigail to the victims of her father, revealing that she actually did help her father kill his victims. Will then decides to check Abigail out of the hospital to save her from the FBI. Hannibal's deception persuades Jack that Will is capable of murder because of his unstable mental health. Hannibal worries aloud whether Will's mentality is gradually dissociating and morphing into Garrett Jacob Hobbs. Jack panics since Hobbs attempted to murder his daughter and he knows Will is currently with Abigail.

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Hannibal consults with his own psychiatrist regarding his obsession with Will's mental health. Will is going insane, and Hannibal views it as an oil leak that he must contain. Yet, Hannibal's doctor wonders what is causing Hannibal's infatuation. What is the source of his fascination with Will? Hannibal believes he views Will as a potential friend. Yet, his psychiatrist warns him that his obsession with Will is nothing if not romantic. She even outright asks Hannibal, "Are you in love with Will Graham?" This realization seems to scare Hannibal.

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Will contaminates a crime scene for the first time, believing he committed the first murder, and an MRI reveals he has Advanced Encephalitis. But, Hannibal unnerves the examining physician into informing Will that he is okay. However, the team is skeptical of Will's claim that he encountered a strange, "dead-looking" woman who may be connected when revisiting the crime site alone. Will returns to the doctor for additional mental health exams, his anxieties spurred by Hannibal, when the doctor is murdered.

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Jack is contacted by a former colleague who believes he has caught the Chesapeake Ripper, one of the most infamous serial killers on the east coast. The team determines that this is not the Ripper when Miriam Lass, Jack's former protege, becomes the next victim. Because of Jack and Miriam's connection o the Ripper, Will decides that he wants to be assigned to the case. The BAU now believes the Ripper has resurfaced, but they are facing backlash from the press about Abigail's involvement with her father's crimes. Many people believe that Abigail may have helped her father. Will's mental health continues to decline, and he begins to hear many strange noises in his head.

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Will, who is now an official special investigator with the FBI, helps Jack search for other serial murderers. Returning to the field weighs heavily on Will's psyche, and Hannibal tries to drive a wedge between Will and Jack.  He and Hannibal are determined to give Abigail closure from her father attempting to kill her, they take her back to the scene of her father's crimes. Will is also having hallucinations of Garrett Jacob Hobbs haunting him, so he believes going back to the scene will help him work through his PTSD.

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Will kills Garrett Jacob Hobbs after Hobbs attacked his daughter and killed his wife. This creates Will's moral obligation to his daughter, Abigail Hobbs. He and Hannibal want to stay close to Abigail to monitor her recovery, which allows theh FBI to carefully watch Will's state after killing someone. Will is now constantly surrounded by the memory of Hobbs' death, and Jack wants him to stay working with the FBI, and he appoints Hannibal Lecter as Will's psychiatrist. This means Will cannot go back to his quiet life as a teacher, and he must continue protecting Abigial while reliving his traumatic memories with Hannibal.

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Hannibal goes to Will's home to tell him Jack has been deposed to court. Hannibal continues to psychoanalyze Will as they visit a construction site that is connected to the latest murder. They both find something strange in Garrett Jacob Hobbs' file, so Hannibal drops some files to purposefully distract Will. Hannibal then discreetly calls Garrett Jacob Hobbs' home, and informs him that "they know." Will's ability to empathize with psychopathic murders fascinates Hannibal, who decides to push the boundaries of Will's frail sanity in order to transform him into a killer.

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Will consults with Jack about officially joining the case, where he meets Hannibal Lecter, a forensic psychiatrist, for the first time. As Jack first suggests that Will and Hannibal work together, he is reluctant to partner with the FBI. When Jack then reveals that the only reason Dr. Lecter is there is to study Will and how his mind works, Will is even more reluctant, stating that he is not a guinea pig to be reviewed and experimented on.

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Jack Crawford, head of the Behavioral Analysis Unit of the FBI,  meets with Will in his classroom and requests his help on a case. He asks Will to investigate a serial killer who had recently abducted and killed eight college girls. Jack believes that Will's talent for empathizing with killers could help him catch the murderer. When they go to speak with the parents of the most recently abducted girl, Will is the one to find her body. This gives Will a moral attachment to this case, so he feels like he has to catch the killer before he returns to teaching.

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Will Graham is a former FBI criminal profiler who uses his unique ability to over-empathize with people to understand how murderers think. This ability take a tremendous mental toll on him. Instead of working as an active FBI agent, he is a professor of forensic pathology to students who are becoming agents.